Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications. Some of the treatments used include barrier products, intralesional corticosteroids, and flurandrenolide-impregnated tape.^[17]

Class Summary

These agents are the treatment of choice. Protective or preventive measures include barrier products to seal the skin from exogenous factors, such as urine, feces, and other external irritants, which may predispose an individual to granuloma gluteale.

Zinc oxide topical (Aveeno Baby Organic Harvest Diaper Rash Cream, Desitin, Desitin Creamy)

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Zinc oxide is a skin protectant generally used to prevent and treat diaper rash. Use 15% ointment or 25% paste.

Class Summary

Intralesional administration is indicated to treat localized hypertrophic, infiltrated inflammatory lesions. Granuloma gluteale infantum, granuloma gluteale adultorum, and diaper area granuloma of the aged fit into this category of lesions. Flurandrenolide-impregnated tape, which combines a barrier with an anti-inflammatory action, has been reported to be beneficial.

Triamcinolone (Kenalog-10)

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Triamcinolone is for inflammatory dermatosis responsive to steroids; it decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Intramuscular injections may be used for widespread skin disorders or intralesional injections may be used for localized skin disorders.

Each mL of sterile, aqueous suspension contains triamcinolone acetonide 10 mg. Nonmedicinal ingredients include benzyl alcohol, carboxymethylcellulose sodium, hydrochloric acid, polysorbate, sodium chloride, sodium hydroxide, and water. It is suspended in sterile sodium chloride solution at a final concentration of 2.5-5 mg/mL.

Flurandrenolide (Cordran tape)

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Flurandrenolide is a topical anti-inflammatory agent supplied as a 4 mcg/cm² topical adhesive tape. Despite the possible causative role of topical corticosteroids in some cases of granuloma gluteale infantum, various hypertrophic lesions have been effectively thinned in 3 days with the use of this treatment.

Questions

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Fujita M, Ohno S, Danno K, Miyachi Y. Two cases of diaper area granuloma of the adult. J Dermatol. 1991 Nov. 18(11):671-5. [QxMD MEDLINE Link].
Maekawa Y, Sakazaki Y, Hayashibara T. Diaper area granuloma of the aged. Arch Dermatol. 1978 Mar. 114(3):382-3. [QxMD MEDLINE Link].
Van L, Harting M, Rosen T. Jacquet erosive diaper dermatitis: a complication of adult urinary incontinence. Cutis. 2008 Jul. 82(1):72-4. [QxMD MEDLINE Link].
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Al-Faraidy NA, Al-Natour SH. A forgotten complication of diaper dermatitis: Granuloma gluteale infantum. J Family Community Med. 2010 May. 17(2):107-9. [QxMD MEDLINE Link].
Dytoc MT, Fiorillo L, Liao J, Krol AL. Granuloma gluteale adultorum associated with use of topical benzocaine preparations: case report and literature review. J Cutan Med Surg. 2002 May-Jun. 6(3):221-5. [QxMD MEDLINE Link].
Robson KJ, Maughan JA, Purcell SD, Petersen MJ, Haefner HK, Lowe L. Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum. J Am Acad Dermatol. 2006 Nov. 55(5 Suppl):S74-80. [QxMD MEDLINE Link].
Sweidan NA, Salman SM, Kibbi AG, Zaynoun ST. Skin nodules over the diaper area. Granuloma gluteale infantum. Arch Dermatol. 1989 Dec. 125(12):1703-4, 1706-7. [QxMD MEDLINE Link].
Bluestein J, Furner BB, Phillips D. Granuloma gluteale infantum: case report and review of the literature. Pediatr Dermatol. 1990 Sep. 7(3):196-8. [QxMD MEDLINE Link].
Maekawa Y, Kiyoi K, Kunitake Y. Hemilateral distribution of papular lesions on the buttock histologically resembling granuloma gluteale infantum. J Dermatol. 2001 Apr. 28(4):231-3. [QxMD MEDLINE Link].
Kikuchi I, Jono M. Letter: Flurandrenolide-impregnated tape for granuloma gluteale infantum. Arch Dermatol. 1976 Apr. 112(4):564. [QxMD MEDLINE Link].

Media Gallery

Photograph of a case of granuloma gluteale infantum.
Photograph of a case of granuloma gluteale adultorum.
Photomicrograph showing the histologic features of a case of granuloma gluteale adultorum. Granuloma gluteale infantum shares identical histologic features (original magnification X100).
Photomicrograph showing the histologic features of a case of granuloma gluteale adultorum. Granuloma gluteale infantum shares identical histologic features (original magnification X450).