Lichen Striatus Medication

Updated: Jun 04, 2018
  • Author: June Kim, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy for lichen striatus are to reduce morbidity and prevent complications.

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Corticosteroids, Topical

Class Summary

Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli. Topical and intralesional steroids do not necessarily hasten resolution of lichen striatus.

Triamcinolone topical (Aristocort, Kenalog)

Topical triamcinolone is used for the treatment of inflammatory dermatoses responsive to steroids.It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Triamcinolone affects the production of lymphokines and has inhibitory effects on Langerhans cells.

Clobetasol (Temovate)

Clobetasol is a slass I superpotent topical steroid. It suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction.

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Corticosteroids, Systemic

Class Summary

Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli.

Prednisone (Deltasone, Prednisone Intensol, Sterapred, Sterapred DS)

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

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Immunomodulators

Class Summary

These agents exert anti-inflammatory effect by inhibiting T-lymphocyte activation. They are safer than topical steroids for prolonged use or in skin folds.

Pimecrolimus, topical 1% cream (Elidel)

Pimecrolimus is an immunomodulator; it inhibits T-cell proliferation and production of cytokines. Pimecrolimus differs from tacrolimus, as it does not inhibit antigen-presenting cells in the skin.

Tacrolimus, topical 0.03%, 0.1% (Protopic)

Tacrolimus is an immunomodulator; it suppresses cytokine release from T lymphocytes.

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