Epidermolytic Ichthyosis (Epidermolytic Hyperkeratosis or Bullous Congenital Ichthyosiform Erythroderma) Medication

Updated: Oct 08, 2021
  • Author: Brittany G Craiglow, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

There is no cure for epidermolytic ichthyosis (EI). The primary goal of therapy is to reduce hyperkeratosis. This can be achieved with topical keratolytics such as lactic acid, alpha-hydroxy acid, or urea. Topical emollients such as those containing glycerin are also often useful. Topical and oral retinoids can lead to significant improvement; however, care must be taken to avoid causing an increase in skin fragility.