Fibrodysplasia Ossificans Progressiva Medication

Updated: Jan 23, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

No effective medical therapy is known for fibrodysplasia ossificans progressiva (FOP). [44, 45] In a mouse model, ruxolitinib reduced phosphorylation of Stat3 and the development of heterotopic ossification [46] ; it has been suggested for use in humans. Novel therapies are being developed; clinical trials have been underway with palovarotene, REGN 2477, and rapamycin. [47]