Dabska Tumor Differential Diagnoses

Updated: May 13, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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DDx

Diagnostic Considerations

Also consider the following:

  • Reactive angioendotheliomatosis

  • Benign intravascular endothelial hyperplasia

  • Angiosarcoma

  • Retiform hemangioendothelioma

  • Hobnail hemangioendothelioma

  • Glomeruloid hemangioma

  • Pseudolymphomatous cutaneous angiosarcoma [22]

  • Cutaneous epithelioid hemangioendothelioma [23]

  • Anastomosing hemangioma [24]

Poorly differentiated Dabska tumor (DT) may resemble other angiosarcomas. Reactive angioendotheliomatosis, benign intravascular endothelial hyperplasia, angiosarcoma, and retiform hemangioendothelioma are all neoplasms that display intravascular proliferations.

Retiform hemangioendothelioma may have occasional intraluminal papillae with hyaline cores as in DT. Although retiform hemangioendothelioma and DT have biologic behavior and some histologic features in common, retiform hemangioendothelioma tends to involve young and middle-aged adults, with a tendency for involvement of the limbs and trunk. A DT-like tumor delineated in an elderly man may represent an intermediate form. Focal morphologic patterns of DT may sometimes be noted in ordinary angiosarcomas. In one series, 14% of 80 patients with angiosarcomas of soft tissue had papillary fronds, delicate and reminiscent of DT in 4 cases. The unique feature of DT is its papillary structure lined by atypical columnar endothelial cells. A similar formation has been noted extravascularly in patch-stage Kaposi sarcoma. These neoplasms do not usually express D2-40 and vascular endothelial growth factor receptor-3. [25]

DT has been described in the testis, first evident in a child as an inguinal hernia. [16]

Polymorphous hemangioendothelioma, a rare vascular tumor of borderline malignant potential, is a distinct entity in the hemangioendothelioma group. [26]

Hobnail hemangioendothelioma in the right thigh has been described as being "Dabska type." [27] It has also been described in the jejunum. [28]

Differential Diagnoses