Dermatologic Manifestations of Generalized Lipodystrophy Medication

Updated: Jun 17, 2022
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Leptin Analogs

Class Summary

Metreleptin may improve complications associated with leptin deficiency in patients with generalized lipodystrophy including hyperglycemia, hyperlipidemia, insulin resistance, and fatty infiltration of the liver.

Metreleptin (Myalept)

Metreleptin is a recombinant leptin analog. It binds to and activates the human leptin receptor (ObR), which belongs to the class I cytokine family of receptors that signals through the JAK/STAT transduction pathway. It is indicated as replacement therapy (in addition to diet) for the complications of leptin deficiency in patients with congenital generalized or acquired generalized lipodystrophy.