Hartnup Disease Medication

Updated: Nov 12, 2021
  • Author: Lidija Kandolf Sekulovic, MD, PhD; Chief Editor: William D James, MD  more...
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Medication Summary

Nicotinic acid or nicotinamide (50-300 mg/d) provides relief from both the skin manifestations and the neurologic manifestations. [3, 23, 37]

Administration of tryptophan ethyl ester (a lipid-soluble tryptophan metabolite) in a child with Hartnup disease at a dose of 20 mg/kg every 6 hours resulted in normalization of serum and cerebrospinal fluid tryptophan levels. [37]



Class Summary

Vitamins are necessary for normal growth and development. These agents are used to replace essential vitamins not obtained in sufficient quantities in the diet or to further supplement levels.

Vitamin B-3 (Niacin, Nicotinic acid, Nicotinamide)

Nicotinamide is more commonly recommended. It is a source of niacin used in tissue respiration, lipid metabolism, and glycogenolysis. It provides relief from skin and neurologic manifestations.