Dermatologic Manifestations of Menkes Kinky Hair Disease Medication

Updated: Jun 25, 2018
  • Author: Suguru Imaeda, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

Antiseizure medications can be helpful for supportive care in Menkes kinky hair syndrome. No other therapy is available.

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Anticonvulsants

Class Summary

These agents prevent seizure recurrence and terminate clinical and electrical seizure activity.

Phenytoin (Dilantin)

Phenytoin may act in the motor cortex, where it may inhibit the spread of seizure activity. Activity of the brainstem centers responsible for the tonic phase of grand mal seizures also may be inhibited. Individualize dosing; if the dose cannot be divided equally, the larger dose should be taken before retiring for the evening.

Carbamazepine (Tegretol)

Carbamazepine may reduce polysynaptic responses and block posttetanic potentiation.

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