Dermatopathia Pigmentosa Reticularis Workup

Updated: Nov 22, 2019
  • Author: Melba Estrella, MD; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

Dermatopathia pigmentosa reticularis (DPR) does not warrant laboratory studies beyond genetic testing because of the lack of consistent report of abnormal results.

Al-Hamdi [21] et al reported an isolated case of DPR with elevated serum cortisol and hepatomegaly.



Excisional or punch cutaneous biopsy of the reticular pigmentation may be helpful when making the diagnosis of dermatopathia pigmentosa reticularis (DPR).


Histologic Findings

The typical histopathologic picture of dermatopathia pigmentosa reticularis (DPR) shows hyperpigmentation of the basal layer with cytoplasmic vacuolization and the presence of melanophages within the reticular dermis. [2, 21] That is, an interface dermatitis can be present.