Dermatofibrosis Lenticularis (Buschke-Ollendorf Syndrome) Differential Diagnoses

Updated: Jul 18, 2019
  • Author: Vernon J Forrester, MD; Chief Editor: Dirk M Elston, MD  more...
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DDx

Diagnostic Considerations

Connective-tissue nevi can occur sporadically or as part of an inherited or congenital disorder such as tuberous sclerosis (shagreen patch), Proteus syndrome, and multiple endocrine neoplasia type 1. The differential diagnosis also includes disseminated nevus anelasticus.

In the absence of osteopoikilosis, familial cutaneous collagenoma, juvenile elastoma, or eruptive collagenoma may be considered. Lack of LEMD3 gene mutation allows for differentiation. [29] Connective-tissue nevi can also occur sporadically

The differential diagnosis of osteopoikilosis includes osteopathia striata, melorheostosis, bone metastases, [30] tuberous sclerosis (see Tuberous Sclerosis), osteomas (Osteoma Cutis), and mastocytosis (Mastocytosis).

Differential Diagnoses