Treatment
Medical Care
No treatment is effective for Naegeli-Franceschetti-Jadassohn (NFJ) syndrome. As with other ectodermal dysplasias, exposure to heat should be limited and sufficient hydration is recommended. Tooth care to prevent early caries is indicated. Doxycycline has been found to interfere with tumor necrosis factor-alpha (TNF-alpha)–mediated signaling and apoptosis in vitro and may have a role in future treatment. [2]
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Activity
Sports-related exercise should be restricted to only nonexhausting activities. In particular, patients with Naegeli-Franceschetti-Jadassohn (NFJ) syndrome can be allowed to swim.
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Media Gallery
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Lack of dermatoglyphics in a patient with Naegeli-Franceschetti-Jadassohn syndrome.
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Reticulated pigmentation on the trunk in a patient with Naegeli-Franceschetti-Jadassohn syndrome.
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Periorbital reticulated pigmentation in a patient with Naegeli-Franceschetti-Jadassohn syndrome.
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Spotty palmoplantar hyperkeratosis in Naegeli-Franceschetti-Jadassohn syndrome.
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Defective denture with yellow spots on the enamel in a patient with Naegeli-Franceschetti-Jadassohn syndrome.
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