Keratolytics

Class Summary

These agents are used for symptomatic relief of dry scaling skin and for exfoliation.

Ammonium lactate 12% (Lac-Hydrin, AmLactin)

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This is an alpha-hydroxy acid and a normal constituent of tissues and blood. It is believed to act as a humectant when applied to the skin. This may influence hydration of the stratum corneum. In addition, when applied to the skin, it may act to decrease corneocyte cohesion. The mechanisms by which this is accomplished are not yet known. It relieves itching and aids healing of skin in mild eczemas and dermatoses, itching skin, minor wounds, and minor skin irritations. It is found in a variety of topical emollient lotions. Ammonium lactate 5% lotion is available over the counter, and lactic acid 12% cream and lotion are available by prescription.

References

McKusick VA. PSEUDOATROPHODERMA COLLI. Online Mendelian Inheritance in Man (OMIM). Available at http://www.omim.org/entry/177350. June 2, 1986; Accessed: August 31, 2018.
Becker SW, Muir KB. Pseudo-atrophoderma colli: A hitherto undescribed condition. Arch Dermatol Syphilol. 1934. 29:53-6.
Ayres S Jr, Ayres S 3rd. Pseudoatrophoderma colli. Arch Dermatol. 1955. 71:763-4.
Obermayer ME, Becker SW. Pseudoatrophoderma colli. Arch Dermatol. 1955. 72:281-2.
Sudy E, Urbina F, Gubelin W, Misad C, Espinoza A. Pseudoatrophoderma colli: distinct entity or just a variant of confluent and reticular papilomatosis of Gougerot-Carteaud. Dermatol Online J. 2020 Oct 15. 26 (10):[QxMD MEDLINE Link]. [Full Text].
Kauh YC, Knepp ME, Luscombe HA. Pseudoatrophoderma colli. A familial case. Arch Dermatol. 1980 Oct. 116(10):1181-2. [QxMD MEDLINE Link].
Palomeque FE, Hairston MA Jr. Confluent and reticulated papillomatosis of Gougerot and Carteaud. Arch Dermatol. 1965 Jul. 92(1):49-51. [QxMD MEDLINE Link].
Abbud Neto S, di Stasi LL, Pires MC, Coletta EN. [Pseudo-atrophoderma colli and Gougerot-Carteaud confluent reticulated papillomatosis (shining atrophy)]. Med Cutan Ibero Lat Am. 1987. 15 (6):477-80. [QxMD MEDLINE Link].
Frost K, Epstein E. Pseudoatrophoderma colli in sisters. Arch Dermatol Syphilol. 1939. 40:755-61.
Kanan MW, Kandil E. Pseudoatrophoderma colli in a male. Br J Dermatol. 1969 Jan. 81(1):65-8. [QxMD MEDLINE Link].

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Contributor Information and Disclosures

Author

Anna Choczaj-Kukula, MD, PhD Consultant Dermatologist, Royal Free London NHS Trust, UK

Anna Choczaj-Kukula, MD, PhD is a member of the following medical societies: British Association of Dermatologists, American Academy of Dermatology, European Academy of Dermatology and Venereology, Royal Society of Medicine

Disclosure: Partner received salary from Johnson & Johnson for management position.

Coauthor(s)

Camila K Janniger, MD Clinical Professor of Dermatology, Clinical Associate Professor of Pediatrics, Chief of Pediatric Dermatology, Rutgers New Jersey Medical School

Camila K Janniger, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Acknowledgements

David F Butler, MD Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic

Disclosure: Nothing to disclose.

Glen H Crawford, MD Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital

Disclosure: Nothing to disclose.

Robert A Schwartz, MD, MPH Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School

Disclosure: Nothing to disclose.

Albert C Yan, MD Section Chief, Associate Professor, Department of Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia and University of Pennsylvania

Disclosure: Nothing to disclose.

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Sections Pseudoatrophoderma Colli
Overview
Presentation
DDx
Workup
Medication
References