Nasopalatine Duct Cyst Differential Diagnoses

Updated: May 13, 2022
  • Author: Piotr Kurnatowski, MD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

A well-circumscribed, heart-shaped, midline radiolucency that is inter-radicular in location between the roots of vital maxillary incisor teeth is virtually pathognomonic for nasopalatine duct cyst; however, other benign entities that develop within the jawbones with some frequency, such as the following, can mimic nasopalatine duct cyst and should be considered in the clinical differential diagnosis [47] :

  • Odontogenic cysts (eg, lateral radicular cyst, lateral periodontal cyst, odontogenic keratocyst)

  • Odontogenic tumors (eg, ameloblastoma, odontogenic myxoma)

  • Nonodontogenic tumors (eg, central giant cell tumor, brown tumor of hyperparathyroidism, central hemangioma, granuloma)

  • Osteitis fistulizing in the palatine direction or a bucconasal and/or buccosinusal communication. [28, 44]

Additional diagnostic procedures (see Workup) can be helpful in further limiting this list to a working diagnosis of nasopalatine duct cyst.

Differential Diagnoses