Reticulate Pigmented Anomaly Differential Diagnoses

Updated: Apr 12, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Kitamura reticulate acropigmentation [37]

  • Haber syndrome [38]

  • Galli-Galli disease [39] - Best considered a subtype of Dowling-Degos disease (reticulate pigmented anomaly) with clinical and histologic features similar to transient acantholytic dermatosis [40]

  • Epidermolysis bullosa with mottled pigmentation

  • Scleroderma - May rarely be associated reticulate hyperpigmentation of the trunk, upper limbs, and lower limbs [41]

The coexistent Dowling-Degos disease and reticulate acropigmentation of Kitamura with progressive multiple common seborrheic keratoses has been described in a family. [42]

Galli-Galli disease, a variant of Dowling-Degos disease, has been described as occurring in a liver transplant recipient with Grover diseaselike, erythematous, keratotic, excoriated papules, and lentigolike macules with predilection for the trunk. [43]

Galli-Galli disease, Dowling-Degos disease, Kitamura disease, Haber syndrome, and reticulate acropigmentation of Dohi may be clinically similar and require careful distinction. [44]  Rarely Dowling-Degos disease may coexist with Darier disease. [45]

Differential Diagnoses