Phytophotodermatitis Medication

Updated: Sep 12, 2019
  • Author: William P Baugh, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli. Low-to-high potency topical steroids may be applied to affected areas to reduce local inflammation induced by the photoactivated psoralens. They may help to relieve the burning sensation associated with phytophotodermatitis as well as to reduce the associated postinflammatory hyperpigmentation.

Hydrocortisone valerate 0.2% cream (Westcort)

Hydrocortisone valerate 0.2% cream treats inflammatory dermatoses responsive to steroids. It dDecreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.

Clobetasol (Temovate)

Clobetasol is a class I superpotent topical steroid; it suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction.

Betamethasone topical (Diprolene, Betatrex)

Betamethasone topical is for inflammatory dermatoses responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.

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Nonsteroidal anti-inflammatory drugs

Class Summary

These agents are most commonly used for relief of mild to moderate pain. Indomethacin is an analgesic and NSAID medication that may offer some protection against acute UV-A–induced epidermal apoptosis as well as provide some relief of skin discomfort.

Indomethacin (Indocin)

Indomethacin has anti-inflammatory properties resulting from the inhibition of prostaglandin synthesis and/or leukocyte migration into inflamed areas. It is rapidly absorbed; metabolism occurs in the liver by demethylation, deacetylation, and glucuronide conjugation.

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