Polymorphous Light Eruption Medication

Updated: Jan 22, 2020
  • Author: Saud A Alobaida, MBBS, FRCPC; Chief Editor: Dirk M Elston, MD  more...
  • Print
Medication

Medication Summary

The goals of pharmacotherapy for polymorphous light eruption (PMLE) are to reduce morbidity and to prevent complications.

Next:

Antimalarials

Class Summary

These agents may have immunomodulatory effects.

Hydroxychloroquine (Plaquenil)

Hydroxychloroquine inhibits chemotaxis of eosinophils, locomotion of neutrophils, and impairs complement-dependent antigen-antibody reactions.

Hydroxychloroquine sulfate 200 mg is equivalent to 155 mg hydroxychloroquine base and 250 mg chloroquine phosphate.

Previous
Next:

Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli.

Prednisone (Deltasone, Meticorten, Orasone)

Prednisone is an immunosuppressant for the treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocyte and antibody production. 

Previous
Next:

Immunomodulators

Class Summary

These agents modify the activity of key factors in the immune system.

Thalidomide (Thalomid)

Thalidomide is only supplied to pharmacies participating in the System for Thalidomide Education and Prescribing Safety (STEPS) program. It is an immunomodulatory agent that may suppress excessive production of tumor necrosis factor-alpha and may down-regulate selected cell surface adhesion molecules involved in leukocyte migration.

Previous
Next:

Vitamins

Class Summary

These agents are essential for normal DNA synthesis and cell function.

Beta carotene

Beta-carotene may provide a limited level of photoprotection. It causes yellowing of skin (carotenoderma). Any photoprotection afforded increases slowly after the drug is commenced over a 4- to 6-week period. When discontinued, skin color and benefit fade over several weeks.

Niacin (Vitamin B-3)

The source of niacin is used in tissue respiration, lipid metabolism, and glycogenolysis.

Previous