Xeroderma Pigmentosum Medication

Updated: Jun 10, 2016
  • Author: Linda J Fromm, MD, MA, FAAD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Retinoids

Class Summary

These agents may prevent some of the neoplasms in xeroderma pigmentosum. They decrease the cohesiveness of abnormal hyperproliferative keratinocytes, and they may reduce the potential for malignant degeneration. They modulate keratinocyte differentiation. They have been shown to reduce the risk of skin cancer formation in patients who have undergone renal transplantation.

Isotretinoin (Accutane)

Isotretinoin is a synthetic 13-cis isomer of the naturally occurring tretinoin (trans- retinoic acid). It is used orally for the treatment of serious dermatologic conditions.

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