Erythema Multiforme Questions & Answers

1. Sokumbi O, Wetter DA. Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist. Int J Dermatol. 2012 Aug. 51(8):889-902. [QxMD MEDLINE Link].

2. Huff JC. Erythema multiforme and latent herpes simplex infection. Semin Dermatol. 1992 Sep. 11(3):207-10. [QxMD MEDLINE Link].

3. Orton PW, Huff JC, Tonnesen MG, Weston WL. Detection of a herpes simplex viral antigen in skin lesions of erythema multiforme. Ann Intern Med. 1984 Jul. 101(1):48-50. [QxMD MEDLINE Link].

4. Schofield JK, Tatnall FM, Brown J, McCloskey D, Navarrete C, Leigh IM. Recurrent erythema multiforme: tissue typing in a large series of patients. Br J Dermatol. 1994 Oct. 131(4):532-5. [QxMD MEDLINE Link].

5. Kämpgen E, Burg G, Wank R. Association of herpes simplex virus-induced erythema multiforme with the human leukocyte antigen DQw3. Arch Dermatol. 1988 Sep. 124(9):1372-5. [QxMD MEDLINE Link].

6. Martire B, Foti C, Cassano N, Buquicchio R, Del Vecchio GC, De Mattia D. Persistent B-cell lymphopenia, multiorgan disease, and erythema multiforme caused by Mycoplasma pneumoniae infection. Pediatr Dermatol. 2005 Nov-Dec. 22(6):558-60. [QxMD MEDLINE Link].

7. Grosber M, Alexandre M, Poszepczynska-Guigne E, Revuz J, Roujeau JC. Recurrent erythema multiforme in association with recurrent Mycoplasma pneumoniae infections. J Am Acad Dermatol. 2007 May. 56(5 Suppl):S118-9. [QxMD MEDLINE Link].

8. Wu CC, Tsai CN, Wong WR, Hong HS, Chuang YH. Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction. J Am Acad Dermatol. 2006 Aug. 55(2 Suppl):S11-5. [QxMD MEDLINE Link].

9. Pavlovic MD, Karadaglic DM, Kandolf LO, Mijuskovic ZP. Persistent erythema multiforme: a report of three cases. J Eur Acad Dermatol Venereol. 2001 Jan. 15(1):54-8. [QxMD MEDLINE Link].

10. Carducci M, Latini A, Acierno F, Amantea A, Capitanio B, Santucci B. Erythema multiforme during cytomegalovirus infection and oral therapy with terbinafine: a virus-drug interaction. J Eur Acad Dermatol Venereol. 2004 Mar. 18(2):201-3. [QxMD MEDLINE Link].

11. Gonzalez-Delgado P, Blanes M, Soriano V, Montoro D, Loeda C, Niveiro E. Erythema multiforme to amoxicillin with concurrent infection by Epstein-Barr virus. Allergol Immunopathol (Madr). 2006 Mar-Apr. 34(2):76-8. [QxMD MEDLINE Link].

12. Mockenhaupt M, Viboud C, Dunant A, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol. 2008 Jan. 128(1):35-44. [QxMD MEDLINE Link].

13. Nettis E, Giordano D, Pierluigi T, Ferrannini A, Tursi A. Erythema multiforme-like rash in a patient sensitive to ofloxacin. Acta Derm Venereol. 2002. 82(5):395-6. [QxMD MEDLINE Link].

14. de Arruda JA, Silva P, Amaral MB, Cotta F, Avendanho R, Mesquita R. Erythema multiforme induced by alendronate sodium in a geriatric patient: A case report and review of the literature. J Clin Exp Dent. 2017 Jul. 9 (7):e929-e933. [QxMD MEDLINE Link].

15. Thami GP, Kaur S, Kanwar AJ. Erythema multiforme due to griseofulvin with positive re-exposure test. Dermatology. 2001. 203(1):84-5. [QxMD MEDLINE Link].

16. Yanes DA, Kaffenberger JA, Carr DR. Erythema multiforme as a reaction to imiquimod 5% cream. Dermatol Online J. 2017 Feb 15. 23 (2):[QxMD MEDLINE Link].

17. Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, et al. Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy. J Dermatol. 2017 Jul. 44 (7):818-821. [QxMD MEDLINE Link].

18. Vivar KL, Deschaine M, Messina J, Divine JM, Rabionet A, Patel N, et al. Epidermal programmed cell death-ligand 1 expression in TEN associated with nivolumab therapy. J Cutan Pathol. 2017 Apr. 44 (4):381-384. [QxMD MEDLINE Link].

19. Conforti C, Currado D, Vezzoni R, Corneli P, Bussani R, Navarini L, et al. Erythema Multiforme Induced by Secukinumab: Clinical, Dermoscopic, and Histological Features. J Clin Rheumatol. 2020 Jan 22. [QxMD MEDLINE Link].

20. Sánchez-González MJ, Barbarroja-Escudero J, Antolín-Amérigo D, Rodríguez-Rodríguez M, Pericet Fernández L, Medina I, et al. Erythema multiforme induced by tramadol: an allergy assessment. J Investig Allergol Clin Immunol. 2020 Feb 11. [QxMD MEDLINE Link].

21. Caro-Gutiérrez D, Floristán Muruzábal MU, Gómez de la Fuente E, Franco AP, López Estebaranz JL. Photo-induced erythema multiforme associated with vandetanib administration. J Am Acad Dermatol. 2014 Oct. 71(4):e142-4. [QxMD MEDLINE Link].

22. Matsuzawa Y, Fujishima S, Nakada T, Iijima M. Erythema multiforme major putatively induced by dihydrocodeine phosphate. Clin Exp Dermatol. 2010 Mar 19. [QxMD MEDLINE Link].

23. Hong SJ, Chang CH. Erythema multiforme-like generalized allergic contact dermatitis caused by Alpinia galanga. Contact Dermatitis. 2006 Feb. 54(2):118-20. [QxMD MEDLINE Link].

24. Werchniak AE, Schwarzenberger K. Poison ivy: an underreported cause of erythema multiforme. J Am Acad Dermatol. 2004 Nov. 51(5 Suppl):S159-60. [QxMD MEDLINE Link].

25. Cohen DM, Bhattacharyya I. Cinnamon-induced oral erythema multiformelike sensitivity reaction. J Am Dent Assoc. 2000 Jul. 131(7):929-34. [QxMD MEDLINE Link].

26. Mayumi M, Heike T, Mikawa H. Transient selective C4 deficiency of infancy. Lancet. 1992 Mar 21. 339(8795):752. [QxMD MEDLINE Link].

27. Lam NS, Yang YH, Wang LC, Lin YT, Chiang BL. Clinical characteristics of childhood erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Taiwanese children. J Microbiol Immunol Infect. 2004 Dec. 37(6):366-70. [QxMD MEDLINE Link].

28. Aydogan K, Karadogan S, Balaban Adim S, Tunali S. Lupus erythematosus associated with erythema multiforme: report of two cases and review of the literature. J Eur Acad Dermatol Venereol. 2005 Sep. 19(5):621-7. [QxMD MEDLINE Link].

29. Kerob D, Assier-Bonnet H, Esnault-Gelly P, Blanc F, Saiag P. Recurrent erythema multiforme unresponsive to acyclovir prophylaxis and responsive to valacyclovir continuous therapy. Arch Dermatol. 1998 Jul. 134(7):876-7. [QxMD MEDLINE Link].

30. Chen T, Levitt J, Geller L. Apremilast for treatment of recurrent erythema multiforme. Dermatol Online J. 2017 Jan 15. 23 (1):[QxMD MEDLINE Link].

31. Baillis B, Maize JC Sr. Treatment of recurrent erythema multiforme with adalimumab as monotherapy. JAAD Case Rep. 2017 Mar. 3 (2):95-97. [QxMD MEDLINE Link].

32. Huff JC. Acyclovir for recurrent erythema multiforme caused by herpes simplex. J Am Acad Dermatol. 1988 Jan. 18(1 Pt 2):197-9. [QxMD MEDLINE Link].

33. Lynn WA, Davidson RN, Wansbrough-Jones MH. Successful use of oral acyclovir to prevent herpes simplex-associated erythema multiforme. J Infect. 1987 Sep. 15(2):192-3. [QxMD MEDLINE Link].

34. Tatnall FM, Schofield JK, Leigh IM. A double-blind, placebo-controlled trial of continuous acyclovir therapy in recurrent erythema multiforme. Br J Dermatol. 1995 Feb. 132(2):267-70. [QxMD MEDLINE Link].

35. Kürkçüoglu N, Alli N. Cimetidine prevents recurrent erythema multiforme major resulting from herpes simplex virus infection. J Am Acad Dermatol. 1989 Oct. 21(4 Pt 1):814-5. [QxMD MEDLINE Link].

36. Khafaga YM, Jamshed A, Allam AA, et al. Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy. Acta Oncol. 1999. 38(1):111-6. [QxMD MEDLINE Link].

Jose A Plaza, MD Director of Dermatopathology, Professor of Pathology and Dermatology, The Ohio State University Wexner Medical Center

Jose A Plaza, MD is a member of the following medical societies: American Medical Association, American Society for Clinical Pathology, American Society of Dermatopathology, International Society of Dermatopathology

Disclosure: Nothing to disclose.

Victor G Prieto, MD, PhD Ferenc and Phyllis Gyorkey Chair for Research and Education in Pathology, Professor, Departments of Pathology and Dermatology, University of Texas MD Anderson Cancer Center

Victor G Prieto, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Medical Association, American Society for Clinical Pathology, American Society of Dermatopathology, College of American Pathologists, European Society of Pathology, International Society of Dermatopathology, Society for Investigative Dermatology, United States and Canadian Academy of Pathology

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Myriad (consultant regarding MyPath test in melanocytic lesions).

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Burke A Cunha, MD Professor of Medicine, State University of New York School of Medicine at Stony Brook; Chief, Infectious Disease Division, Winthrop-University Hospital

Burke A Cunha, MD is a member of the following medical societies: American College of Chest Physicians, American College of Physicians, and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Steven C Dronen, MD, FAAEM Chair, Department of Emergency Medicine, LeConte Medical Center

Steven C Dronen, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

James Foster, MD, MS Consulting Staff, Department of Emergency Medicine, Palomar Pomerado Health

James Foster, MD, MS is a member of the following medical societies: Alpha Omega Alpha, American College of Emergency Physicians, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Warren R Heymann, MD Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Jeffrey Lee Kishiyama, MD Assistant Clinical Professor of Medicine, University of California, San Francisco, School of Medicine; Consulting Staff, Allergy and Asthma Associates of Santa Clara Valley Research Center

Disclosure: Nothing to disclose.

Olufunmilayo Ogundele, MD Clinical Assistant Instructor, Staff Physician, Departments of Emergency and Internal Medicine, State University of New York Downstate, Kings County Hospital Center

Olufunmilayo Ogundele, MD is a member of the following medical societies: American Medical Association and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chulabhorn Pruksachatkunakorn, MD Chief, Division of Dermatology, Professor, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Thailand

Chulabhorn Pruksachatkunakorn is a member of the following medical societies: American Academy of Dermatology, International Society of Pediatric Dermatology, and Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Don R Revis Jr, MD Consulting Staff, Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine

Don R Revis Jr, MD is a member of the following medical societies: American College of Surgeons, American Medical Association, American Society for Aesthetic Plastic Surgery, and American Society of Plastic Surgeons

Disclosure: Nothing to disclose.

Mark A Silverberg, MD, MMB, FACEP Assistant Professor, Associate Residency Director, Department of Emergency Medicine, State University of New York Downstate College of Medicine; Consulting Staff, Department of Emergency Medicine, Staten Island University Hospital, Kings County Hospital, University Hospital, State University of New York Downstate Medical Center

Mark A Silverberg, MD, MMB, FACEP is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, Council of Emergency Medicine Residency Directors, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Debra Slapper, MD Consulting Staff, Department of Emergency Medicine, St Anthony's Hospital

Debra Slapper, MD is a member of the following medical societies: American Academy of Emergency Medicine

Disclosure: Nothing to disclose.

Michael J Wells, MD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

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