Transient Acantholytic Dermatosis Differential Diagnoses

Updated: Mar 17, 2020
  • Author: Clay J Cockerell, MD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Clinical differential diagnoses and their key differentiating features are listed below:

  • Dermatitis herpetiformis - Vesicular; pruritus more severe; extensor distribution

  • Folliculitis - Follicular papules; pustules if lesions intact

  • Arthropod reaction - Tendency to cluster; extremities and exposed sites usually involved

  • Papular urticaria (prurigo simplex) - Primarily excoriations; unreachable areas tend to be spared

  • Miliaria rubra - History of exacerbation with heat; often more nodular lesions

  • Papular drug eruption - Papules tend to coalesce into plaques; no sparing of extremities

  • Disseminated herpes simplex or herpes zoster - Vesicular; painful; history of immunosuppression

  • Scabies - Intractable itching, worse at night; wrists, finger webs, and axillae affected

  • Papular pityriasis rosea - Herald patch, less severe or absent pruritus, collarette of scale; seasonal incidence

  • Secondary syphilis - Usually scaly, with palmar lesions; pruritus is mild or absent

  • Galli-Galli disease [13] - Primarily affects lower extremities, groin, hands (larger body parts)

  • Darier disease- Follicular involvement

  • Pemphigus foliaceus - Erosions

Differential Diagnoses