Overview
What is transient acantholytic dermatosis (Grover disease)?
What is the pathophysiology of transient acantholytic dermatosis (Grover disease)?
What is the prevalence of transient acantholytic dermatosis (Grover disease)?
What is the racial predilection of transient acantholytic dermatosis (Grover disease)?
What is the sexual predilection of transient acantholytic dermatosis (Grover disease)?
Which age groups are at highest risk for transient acantholytic dermatosis (Grover disease)?
What is the prognosis of transient acantholytic dermatosis (Grover disease)?
Presentation
What are the signs and symptoms of transient acantholytic dermatosis (Grover disease)?
Which physical findings are characteristic of transient acantholytic dermatosis (Grover disease)?
What are the complications of transient acantholytic dermatosis (Grover disease)?
DDX
How is transient acantholytic dermatosis (Grover disease) differentiated from other skin conditions?
What are the differential diagnoses for Transient Acantholytic Dermatosis?
Workup
Which histologic findings are characteristic of transient acantholytic dermatosis (Grover disease)?
What are key histologic patterns and features of transient acantholytic dermatosis (Grover disease)?
Treatment
How is transient acantholytic dermatosis (Grover disease) treated?
How is transient acantholytic dermatosis (Grover disease) prevented?
Medications
What is the role of drug treatment for transient acantholytic dermatosis (Grover disease)?
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A 54-year-old man with a pruritic eruption on the trunk. Notice the slight lichenification and significant erythema from rubbing that is localized to the central part of the torso. Also note the red-brown papules in the abdominal region.
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Close-up view of the abdominal area of a patient with a pruritic eruption on the trunk. Multiple, small, discrete, red-brown papules characteristic of Grover disease are present.
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Histopathology of Darier-type Grover disease. A focus of acantholytic dyskeratosis is present in the epidermis with slight epithelial hyperplasia and hyperkeratosis, a sign of rubbing as a consequence of the pruritic nature of the disease (hematoxylin and eosin, original magnification X40).
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Higher magnification reveals the acantholytic dyskeratosis to better advantage. Note the corps ronds and grains (hematoxylin and eosin, original magnification X400).