Cheek Reconstruction Treatment & Management

Updated: Mar 28, 2019
  • Author: Jodi Stengem Markus, MD; Chief Editor: Dirk M Elston, MD  more...
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Surgical Therapy

Secondary intention healing

For selected defects within the cheek, secondary intention healing may offer acceptable functional and aesthetic results. This is particularly true for small, superficial defects located in concave areas of the cheek, such as the preauricular sulcus, melolabial crease, and facial-alar groove. [16] A large lateral cheek defect that cannot be closed primarily, in a patient who cannot tolerate complicated reconstructive options, may heal by secondary intention with a reasonable result (see the image below).

Left: Large lateral cheek defect without recruitab Left: Large lateral cheek defect without recruitable adjacent tissue for closure is left to granulate. Right: 1 month later, the defect is beginning to contract.

Large defects on the medial cheek, particularly when deep, often distort the free margin of the eyelid or lip in an unacceptable manner. In such cases, guiding sutures can be useful to direct the natural forces of wound contraction away from margin distortion. [17] The color of the patient’s skin should also be considered, especially with larger defects, as the mature scar formulated via secondary intention healing is often hypopigmented. An additional disadvantage is the lengthy postoperative course as the wound is granulating. Proper wound management by the patient is an important aspect of secondary intention healing because it minimizes pain, prevents infection, and enhances reepithelization. [18] A first-choice option for concave defects, secondary intention healing is largely a last-choice option for most of the cheek.

Primary closure

Primary closure is often the treatment of choice for small or medium-sized defects of the cheek, providing an expedient closure, rapid healing time, and excellent aesthetic result. [10] Resultant scars should be placed within cosmetic unit junctions or along relaxed skin tension lines. Prior to the infiltration of local anesthesia, the relaxed skin tension lines and cosmetic unit junction lines may be outlined to ensure perfect alignment at the time of closure. Moving the patient to an upright position after principle suture placement is also helpful to assess the effects of gravity.

The aging face provides multiple reservoirs of tissue redundancy that can be used in cheek reconstruction, such as the preauricular area, deepened melolabial folds, and pronounced jowls. [14] Even large cheek defects can be repaired primarily with minimal scar visibility if the patient has sufficient skin laxity and photodamage (see the image below).

Left: Large lower cheek defect with adjacent skin Left: Large lower cheek defect with adjacent skin laxity. Middle: Immediately after primary closure along melolabial fold. Right: 3 months later.

Many modifications of the standard elliptical excision or standing cone repair technique can be used during primary closure to camouflage scars. [19]  A crescentic or lazy-S modification is often helpful to mimic the physiologic curve over convex surfaces and reduce standing cone formation. Historically, Z-plasty has been suggested to break long, linear scars into smaller, less visible partitions. Data from 2016, however, suggest that long, linear cheek scars may be perceived by the public more favorably than a series of zig-zags. [20] Care should be taken to attend to the principles of skin biomechanics, such as creep and stretch, because excess wound tension and compromised circulation foster the development of scar widening and boost the incidence of wound necrosis, infection, and dehiscence. [11] Free margin preservation is a primary principle of facial reconstruction. If primary side-to-side closure results in an excessively long scar, increased wound tension, or distortion of a free margin, other options should be pursued.

Skin grafting

The split-thickness skin graft provides a convenient window for tumor surveillance. However, discrepancies in skin color/texture and significant wound contracture limit the effective use of this technique either to wounds in which tumor surveillance outweighs cosmetic outcome or to those that cannot be repaired by any other method. [21] The electric Zimmer dermatome is an effective tool for harvesting a split-thickness skin graft, although other methods can be used. [22] .

Full-thickness skin grafts on the cheek generally produce an inferior aesthetic result because they are poorly matched in skin color, skin texture, and hair quality. [23] Moreover, they usually cannot fill the deep subcutaneous defect created after tumor extirpation in a convex area. In fact, patient satisfaction has been shown to be significantly higher after local flap closure of cheek defects compared with full-thickness skin grafts. [24] Occasionally, repairing part of a large wound primarily and using the excised Burrow triangle as a full-thickness graft for the remaining defect is useful. A local graft provides a better color/texture match than skin from a distant donor site. (see the image below).

Left: Melanoma excised on superior cheek. Middle: Left: Melanoma excised on superior cheek. Middle: A local full-thickness skin graft is obtained from inferior dog-ear and sutured in place. Right: 3 weeks later, eyelid margin is not distorted. A spot dermabrasion may be necessary at 2 months.

Even so, contour irregularities often ensue, and they can be modified with adjunctive spot dermabrasion or intralesional steroid injections. The graft should be oversized to allow for some contracture, particularly when this technique is applied near free margins. Vascular lasers may address graft erythema or reactive telangiectasias along the graft periphery.

The initial step in creating a full-thickness skin graft is harvesting tissue from the donor site. This is often accomplished by using the defect to generate a template. The donor site is then prepared and draped in a sterile fashion and the template is used to outline the graft, which should be slightly oversized (3-5%) to allow for shrinkage. [25] Undersized grafts lead to increased tension and may ultimately result in graft failure, while excessive tissue can create a pin-cushioning effect. The donor site is then injected with local anesthesia, the graft is harvested to the level of subcutaneous fat, and the donor site closed. Although exceptionally rare, the iatrogenic spread of Merkel cell carcinoma in an immunocompromised patient to a distant graft donor site has been reported. The aggressive tumor, presumably transferred via contaminated surgical excision tools used for graft harvesting, serves as a reminder of the importance of meticulous attention to detail during cutaneous surgical procedures. [26]

The graft should be defatted before it is placed into the defect, rotated, and trimmed until a precise fit is obtained. Several interrupted sutures secure the graft into its recipient bed before the entire perimeter is meticulously approximated with epidermal stitches. Basting sutures are sometimes helpful to facilitate inosculation. Bolsters provide additional support to the graft and are commonly secured with tie-over sutures or adhesive wound closure tapes. The bolster is left in place for 5-7 days. A light nonadherent bandage and pressure dressing is placed over the bolster and removed after 24-48 hours.

Skin substitutes

The development of bioengineered skin substitutes has led to a novel reconstructive option that is both safe and effective. [27, 28] A variety of manufactured dermal substitute products are available and have been used for the reconstruction of full- or partial-thickness cutaneous defects of the cheek. [29] They are particularly useful for larger defects that cannot be repaired easily using traditional closure methods in the setting of complex clinical comorbidities. [30] Wound healing time and clinical appearance of the wound using these products are both typically improved when compared with secondary intention healing. [31] A detailed review of the application of these products is beyond the scope of this article.

Local cutaneous flaps

When primary closure of a cheek defect is not possible, a local tissue flap is usually the next best reconstructive option. [10, 11] Skin flaps can be categorized in several ways, including based on blood supply (eg, axial, random), method of flap movement (eg, advancement, rotation), or shape (eg, rhombic, bilobe). [21] The cheek is sufficiently vascular such that random pattern flaps, when designed properly, provide excellent aesthetic and functional results. In fact, all of the flaps described below are be based on deep or lateral vascular pedicles and do not necessarily require larger caliber named vessels.

Flap movement is a convenient and familiar way to divide the random pattern of local cutaneous flaps used in cheek reconstruction and is thus the categorical scheme used below. Neither hinged nor interpolation flaps are used with any frequency in cheek reconstruction and have been omitted from this discussion. Complex myocutaneous free flaps, or the use of tissue expanders, may be needed to repair extensive and full-thickness wounds but are beyond the scope of this article. [32, 33, 34]


Advancement flaps are moved into a defect by being stretched, in a linear fashion, toward it. As such, tension is only minimally diminished, and the tension vector is not altered. [35] Tissue advancement is an effective closure method for many cheek defects. [36] The primary benefit is the redistribution of tissue redundancies or dog-ears, while minimal tension release is a secondary gain. [37] An example of this is the Burrow advancement flap, which is particularly useful for preauricular defects, because it provides a vertical incision line and adequate redundant tissue from the preauricular crease (see the image below).

Left: Preauricular defect with skin laxity inferio Left: Preauricular defect with skin laxity inferiorly. Middle: A Burow advancement flap is elevated into defect. Right: 1 month later.

Similarly, infraorbital/medial cheek defects may be reconstructed with a Burrow advancement flap that has a component of rotation. The curved superior border of the flap can be positioned along the infraorbital rim (see the image below). When possible, this flap should be extended laterally above the level of the lateral canthus to minimize the risk of ectropion. Although it is easy to separate advancement motion from rotation in principle, in reality, most rotation flaps contain a component of advancement, and advancement flaps occasionally contain some rotation. The term sliding flap is often used to describe these 2 motions collectively. [38]

Left: Infraorbital defect with a Burow advancement Left: Infraorbital defect with a Burow advancement flap designed. This flap also has component of rotation. The flap is extended above the level of the lateral canthus. Right: 2 months later, proper lower eyelid alignment is preserved.

Advancement flap design is uncomplicated. Parallel incisions made perpendicular to the defect allow the tissue between them to slide toward the wound. Multiple forces inhibit tissue movement, some of which can be altered. Undermining of the flap pedicle releases deep attachments and should be performed below the level of the subdermal plexus to encourage flap survival. If further movement of the flap is required, undermining beneath the base of the pedicle can be undertaken cautiously and in small increments because it clearly compromises vascular input. This is a process of diminishing returns, and, when the maximum benefit has been achieved, the surgeon may begin to consider additional release by increasing the flap length. Often, the forces inhibiting flap movement are such that lengthening the flap does not significantly increase tissue advancement. A general guideline states that flap length should not exceed width beyond a ratio of 3:1. [37]

Principle suture placement should be at the point of maximum flap tension, which is usually from the leading edge of the flap to the far edge of the defect. [39] Afterwards, the remainder of the flap is sewn into place and the resulting tissue redundancies can be either sewn out by the rule of halves or can be removed by a variety of methods, such as Burrow triangles or M-plasty. [40] Flap viability should be confirmed by observing the color at rest or testing capillary refill time.

Multiple variations of this simple tissue transfer technique have been developed. Double advancement flaps, such as the A-to-T or O-to-H, can be helpful when filling larger defects, but these are not generally used in cheek reconstruction because too many straight lines are created. [10, 39]

The V-Y advancement flap, or island pedicle flap, has been used with success in this area, particularly near the melolabial fold when 1 or 2 of the lines can be integrated into a junction line. The longer sides of the island pedicle are situated along relaxed skin tension lines, while the leading edge of the flap tends to lie perpendicular to these lines. This flap is designed with a deep vascular pedicle and all lateral dermal attachments are severed. The blood supply is from the subcutaneous tissue and musculature and is so rich that this technique may be applied successfully even in devascularized tissue, such as can be seen after radiation therapy.  

Some authors have noted a puffiness from this flap that can be difficult to correct, particularly over the convex portions of the cheek. This trap-door effect can theoretically be minimized by under-sizing the flap and placing it under some tension. [40] It cannot be reliably prevented, however, particularly in younger skin. [41] Multiple modifications of the island pedicle flap have been developed, including a bilateral version, the creation of a transposition flap, or burying the entire pedicle in a subcutaneous tunnel. Placing the incisions in a curvilinear fashion, such that both advancement and slight medial rotation occur, can be useful in cheek reconstruction. This results in a horizontal displacement of tension vectors and is less likely to distort free margins (see the image below). In 2019, a flipped variation of the island pedicle flap has been suggested to reconstruct larger defects of the preauricular cheek to minimize tissue manipulation and maintain the hairless region of skin between the tragus and sideburn in male patients. [42]

Left: Middle cheek defect with proposed island ped Left: Middle cheek defect with proposed island pedicle flap repair. Note that curvilinear lateral incisions will provide a component of rotation, thus minimizing tension on the lower eyelid. Middle: Flap sutured with no free margin distortion. Right: 2 months later.


Sometimes, altering the direction of wound closure tension is necessary when repairing a surgical defect. Rotation flaps accomplish this while recruiting tissue from nearby skin laxity. A rotation flap is designed to allow adjacent skin to rotate along a pivot point into the wound (see the image below). In doing so, a secondary defect is created that is equal in area to the primary one, but it has a long, crescentoid shape, which diffuses and redirects the stress of wound closure. [43] The design implies a curved line, which makes this flap useful when placing scars along relaxed skin tension lines during cheek reconstruction. Yet, a curved line over a convex surface may foster tethering and produce a depressed scar. [2]

Left: Lower cheek defect with rotation flap design Left: Lower cheek defect with rotation flap designed. Right: Flap sutured with minimal and temporary tension on upper lip. The lower limb of the flap falls along the melolabial fold.

When a medial cheek defect is large, some authors prefer to replace the entire cosmetic unit with a laterally and inferiorly based rotation/advancement flap. [44] These large flaps can hide incision lines along cosmetic unit junction lines such as the infraorbital crease, preauricular crease, and nasofacial junction. Ectropion, immediate or delayed, is an uncommon but possible association with such flaps and can be minimized by special techniques, including periosteal anchoring sutures, to prevent lower lid retraction. [45, 46, 47]

The arc of the rotation flap is typically 2-4 times longer than the arc of the defect it needs to close. [48] Obviously, wound closure tension disperses with increasing flap length, but the disadvantage is a longer scar. Curvature of the flap increases mobility, but it also redirects wound closure stress and reduces flap blood supply. Mobility may be further augmented by wide undermining beneath the flap pedicle and pivotal area. If additional movement is required, a back-cut can be made into the flap pedicle, but this should be done conservatively because it greatly reduces vascular input. In 2017, a variation of the conventional, anterior-based cervicofacial flap was reported to conserve the sideburn area while using the large tissue reservoir available in that location. [49] The O-to-Z flap, a double-rotation flap, recruits tissue from opposite sides of the wound and can be tissue conservative, taking the Burrow triangles created by primary closure and rotating them inward rather than excising them. [50] Rotation flaps often necessitate long incision lines for adequate movement, and, therefore, other flap options may produce superior results.


Transposition flaps or lifting flaps also redistribute wound closure tension. The unique advantage of this tissue transfer technique is the ability to recruit tissue from distant sites. This flap is designed to use tissue from a reservoir that is lifted over uninvolved skin to cover the recipient site. [51] The incision lines from these flaps are shortened and geometric in contrast to the long, straight lines produced by sliding flaps.

Many varieties of transposition flaps have been developed, the most common being rhombic, bilobe, and Z-plasty. Inferiorly based rhombic transposition flaps use preauricular, temple, lower cheek, or cervical skin to repair a defect, in which most final incisions lie along relaxed skin tension lines (see the first image below). This flap is particularly useful in the infraorbital region to minimize an ectropion (see the second image below). Banner flaps are modified rhombic transposition flaps in which the pedicle is unusually long, usually 3:1 to 5:1. [51]

Left: A round defect is squared off as a rhombic f Left: A round defect is squared off as a rhombic flap is designed to recruit lax cervical skin. Middle: Rhombic flap sutured in place. Right: Several months later.
Left: A rhombic flap is designed to use looser per Left: A rhombic flap is designed to use looser periorbital tissue to repair an infraorbital defect. Middle: Flap sutured in place. Right: 6 months later, no eyelid distortion occurred.

Another rhombic modification, the 30° Webster flap, is useful in dividing wound closure tension between the primary and secondary defects (see the image below). Bilobed flaps have can be helpful for preauricular, infraorbital, or central cheek defects. However, the curved incisions may prove aesthetically suboptimal. [52]

Left: A large lateral cheek defect with a proposed Left: A large lateral cheek defect with a proposed 30° Webster flap recruited from cervical and preauricular skin. Middle: Flap sutured. Right: 9 months later.

The Z-plasty has traditionally been used to revise traumatic or iatrogenic scars by lengthening them and redirecting wound closure lines. Z-plasty can also be used to reconstruct defects on the cheek that are too large for primary closure. [53] The Z-plasty may be designed so that most final incisions are aligned along relaxed skin tension lines and divide a long linear scar into a series of smaller defects (see the first image below). Larger defects may require a multiple Z-plasty or concomitant parietal defect closure, where possible (see the second image below).

Top left: Cheek defect. Top right: A search for la Top left: Cheek defect. Top right: A search for lax skin reveals easier closure perpendicular to relaxed skin tension lines. Bottom Left: A proposed Z-plasty is drawn. Bottom right: Z-plasty sutured in place with no distortion of the lower eyelid and providing limbs that run along relaxed skin tension lines.
Top left: Large cheek defect. Top right: Lax skin Top left: Large cheek defect. Top right: Lax skin provides closure perpendicular to relaxed skin tension lines. A double Z-plasty is drawn. Bottom left: The double Z-plasty is sutured. Bottom right: 6 months later, several Z-plasty limbs have faded along relaxed skin tension lines.

An understanding of flap geometry, knowledge of primary and secondary tissue movement, and much practice are needed to consistently achieve satisfactory results with transposition flaps. The interested reader is advised to consult the textbooks listed in the references section for further information.



The complications associated with cheek reconstruction consist of the standard complications associated with other cutaneous procedures. A 2018 literature review suggests that the cheek may be associated with a slightly higher rate than other regions of the face. [54] Long-term follow up has been suggested to improve the early detection rate of delayed ectropion. [55] The most common and notable complications are infection, tissue necrosis, wound dehiscence, bleeding, and hematomas. [56] Other adverse sequelae encountered by the dermatologic surgeon include suture reactions, contact dermatitis (often to topical antibiotic postoperative therapy), postinflammatory hyperpigmentation or hypopigmentation, edema, erythema, reactive telangiectasias, widened or hypertrophic scarring, and sensory or motor nerve damage.

Some complications unique to this area of the face include eyelid swelling or bruising, ectropion or eclabium, and parotid fistula formation. A detailed description of complication recognition and management is beyond the scope of this article.


Outcome and Prognosis

When designed properly, most cheek reconstruction repairs after tumor extirpation result in an excellent functional and aesthetic prognosis. Scar revision following cutaneous surgery is not uncommon, and a variety of methods, such as injection, debulking, and nonablative or ablative resurfacing may be undertaken to improve the final outcome. [57, 58]   A combination approach, addressing scar tension, erythema, and scar texture as distinct clinical features, is often helpful. [59] As our understanding of the subtleties that comprise a visually appealing face and those components that detract from it increases, reconstructive efforts will evolve to become more effective. A mastery of technical skill and artistic talent facilitate the reconstructive surgeon’s reapproximation of native anatomy.