Bowenoid Papulosis Medication

Updated: Nov 07, 2019
  • Author: Mary V Kaldas, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Destruction of the lesion is the treatment of choice for bowenoid papulosis. Most medications act to some degree as both destructive and immunomodulating agents.

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Keratolytic agents

Class Summary

These agents inhibit cell proliferation by blocking the progression of the cell cycle at specific stages.

Podophyllum resin (Pod-Ben, Podocon-25, Podofin)

Podophyllum resin is topical treatment for benign growths including external genital and perianal warts, papillomas, and fibroids. It arrests mitosis in the metaphase; the active agent is podophyllotoxin; the type of podophyllum resin used determines the strength. American podophyllum contains one fourth of the amount reported by an Indian source.

Trichloroacetic acid (Tri-Chlor)

Trichloroacetic acid cauterizes skin, keratin, and other tissues. Although caustic, it causes less local irritation and systemic toxicity than others in the same class; however, the response often is incomplete and recurrence occurs frequently.

Imiquimod (Aldara)

Imiquimod induces secretion of interferon alpha and other cytokines; the mechanisms of action are unknown.

5-Fluorouracil cream (Efudex, Adrucil, Fluoroplex)

5-Fluorouracil cream is for treatment-resistant bowenoid papulosis. It interferes with DNA synthesis by blocking the methylation of deoxyuridylic acid, and it inhibits thymidylate synthetase, which subsequently reduces cell proliferation.

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