Epidermodysplasia Verruciformis Treatment & Management

Updated: Mar 08, 2019
  • Author: Anthony A Gaspari, MD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

No therapy for epidermodysplasia verruciformis is definitive. Treatment of epidermodysplasia verruciformis includes preventive measures, the most important of which is strict sun avoidance and protection, beginning as soon as the diagnosis is made.

Nonsurgical therapies for the management of skin cancers include topical imiquimod and 5-fluorouracil, systemic retinoids, interferon, and 5-aminolevulinic acid photodynamic therapy. [48, 49] In 2016, Kim et al described the first case of a patient with imiquimod-resistant epidermodysplasia verruciformis, which was successfully treated with topical ingenol mebutate. [50]

In advanced human papillomavirus (HPV)–related carcinomas, an experimental therapy involves treatment with a combination of 13-cis retinoic acid and interferon-alfa or cholecalciferol analogues. [51]

For localized multiple malignant lesions, autotransplantation of skin from uninvolved areas has been reported with success in preventing further development of cancers.

UV-B exposure, UV-A exposure, and x-ray irradiation should be avoided because radiation therapy often promotes the recurrence of more aggressive skin cancers.


Surgical Care

Surgical and electrosurgical removal and cryotherapy are used in the treatment of benign and premalignant skin lesions. Surgery is also indicated for treatment of malignant lesions. If skin grafting is necessary, the graft should be from sun-protected skin. [52]