Workup
Laboratory Studies
In response to the early acute febrile presentation, laboratory studies may include a CBC count, urinalysis, blood cultures, and cerebrospinal fluid examination.
If the patient presents with a febrile seizure, a seizure workup may be indicated.
Roseola infantum diagnosis may be confirmed by virus isolation, seroconversion (immunoglobulin M), or detection of viral DNA sequences in peripheral blood mononuclear cells.
Specific antibodies to differentiate human herpesvirus (HHV)–6A- and HHV-6B can be determined using a serological assay based on immunoblot analysis using recombinant HHV-6A p100 and HHV-6B 101K. [12]
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Histologic Findings
Typical ballooning cells may be seen in any organ system affected with HHV-6 infection.
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Roseola infantum. Image courtesy of Wikimedia Commons.
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Roseola infantum. Image courtesy of Wikimedia Commons.
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