Roseola Infantum Workup

Updated: Oct 09, 2020
  • Author: Christopher R Gorman, MD; Chief Editor: William D James, MD  more...
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Laboratory Studies

In response to the early acute febrile presentation, laboratory studies may include a CBC count, urinalysis, blood cultures, and cerebrospinal fluid examination.

If the patient presents with a febrile seizure, a seizure workup may be indicated.

Roseola infantum diagnosis may be confirmed by virus isolation, seroconversion (immunoglobulin M), or detection of viral DNA sequences in peripheral blood mononuclear cells.

Specific antibodies to differentiate human herpesvirus (HHV)–6A- and HHV-6B can be determined using a serological assay based on immunoblot analysis using recombinant HHV-6A p100 and HHV-6B 101K. [12]


Histologic Findings

Typical ballooning cells may be seen in any organ system affected with HHV-6 infection.