Ulnar Neuropathy Medication

Updated: Aug 31, 2022
  • Author: Elanagan Nagarajan, MD, MS; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications. 


Tricyclic Antidepressants

Class Summary

Tricyclic antidepressants (TCAs) are effective in painful paresthesias. Whereas the drugs in this category are administered in similar dosages, their sedative properties vary. Amitriptyline may be given if the patient suffers from insomnia, whereas nortriptyline and desipramine are better choices when sedation becomes a problem.


Amitriptyline inhibits the reuptake of serotonin and norepinephrine by the presynaptic neuronal membrane and thus may increase their synaptic concentrations in the central nervous system (CNS). Therefore, the dosage may be increased slowly up to a maximum of 125 mg/day. If no response is obtained, a different TCA may provide some benefit, but more often, it is preferable to use a drug from another category (eg, an anticonvulsant).

Nortriptyline (Pamelor)

Nortriptyline has demonstrated effectiveness in the treatment of chronic pain. It inhibits the reuptake of serotonin and norepinephrine by the presynaptic neuronal membrane and thus may increase their synaptic concentrations in the CNS. In addition, the pharmacodynamic effects of nortriptyline (eg, desensitization of adenyl cyclase and downregulation of beta-adrenergic receptors and serotonin receptors) also appear to play a role in its mechanisms of action. 

Desipramine (Norpramin)

Desipramine is a neurotransmitter reuptake inhibitor for norepinephrine and serotonin. It inhibits reuptake by the neuronal membrane, and it may also down-regulate beta-adrenergic receptors and serotonin receptors.

Duloxetine (Cymbalta, Irenka)

Duloxetine is indicated for diabetic peripheral neuropathic pain. It is a potent inhibitor of neuronal serotonin and norepinephrine reuptake.


Antiarrhythmic Agents Class 1b

Class Summary

Mexiletine, which has been used in various forms as an antiarrhythmic and local anesthetic, tends to blunt some of the stinging and burning of neuropathic pain in some patients. It is used off label for diabetic neuropathy.


Mexiletine is an orally active local anesthetic that is structurally related to lidocaine. It may operate by reducing spontaneous discharges from damaged primary small nerve fibers. Mexiletine is recommended only in intractable cases and can be used for both dysesthetic and paresthetic pain. 


Analgesics, Opioids

Class Summary

Traditionally, narcotics have been avoided in patients with peripheral neuropathies; however, they are useful in many cases.

Morphine sulfate (Astramorph, MS Contin, Kadian, Oramorph)

Morphine sulfate is the drug of choice for analgesia in ulnar neuropathy because of its reliable and predictable effects, good safety profile, and ease with which its effects can be reversed with naloxone. Various intravenous dosages are used; the dosage is commonly titrated until the desired effect is obtained. 



Class Summary

Many anticonvulsants are used to alleviate painful dysesthesias, which frequently accompany peripheral neuropathies. Although they have many different mechanisms of action, their use for alleviating neuropathic pain probably depends on their general tendency to reduce neuronal excitability.

Gabapentin (Neurontin, Gralise)

Gabapentin is a membrane stabilizer, a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); paradoxically, it is thought not to exert an effect on GABA receptors. Instead, it acts via the alpha2-delta1 and alpha2-delta2 auxiliary subunits of voltage-gated calcium channels. Gabapentin is used to manage pain and provide sedation in neuropathic pain. 

Pregabalin (Lyrica)

Pregabalin is a structural derivative of GABA. Its mechanism of action is unknown; it is known to bind with high affinity to alpha2-delta subunits of calcium channels. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulating calcium-channel function. It is approved by the US Food and Drug Administration (FDA) for neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia and as adjunctive therapy in partial-onset seizures.

Lamotrigine (Lamictal)

Lamotrigine is a triazine derivatives useful in the treatment of neuralgia. It inhibits glutamate's release and voltage-sensitive sodium channels, stabilizing the neuronal membrane. The manufacturer's recommendation for dosage adjustments should be followed. 

Topiramate (Topamax, Qudexy XR, Trokendi XR)

The precise mechanism by which topiramate acts is unknown. Still, the following properties may contribute to efficacy: (1) electrophysiologic and biochemical evidence showing blockage of voltage-dependent sodium channels, (2) augmentation of GABA activity at some GABA-A receptor subtypes, (3) antagonism of the AMPA/kainate subtype of the glutamate receptor, and (4) inhibition of carbonic anhydrase, particularly isozymes II and IV. 

Levetiracetam (Keppra, Keppra XR)

Levetiracetam is another new anticonvulsant used to combat the pain of peripheral neuropathies. The mechanism by which it alleviates pain is not known but is probably related to the fact that anticonvulsants generally reduce nerve irritability. Levetiracetam is not FDA-approved for this indication. 

Phenytoin (Dilantin, Phenytek)

Phenytoin blocks sodium channels nonspecifically and therefore reduces neuronal excitability in sensitized C-nociceptors. It is effective in neuropathic pain but suppresses insulin secretion and may precipitate hyperosmolar coma in patients with diabetes. Its antineuralgic effects may derive from blocking post-tetanic potentiation by reducing the summation of temporal stimulation. 

Carbamazepine (Tegretol, Carbatrol, Epitol, Equetro)

Carbamazepine is a sodium-channel blocker that typically provides substantial or complete relief of pain in 80% of individuals with idiopathic and multiple sclerosis−associated trigeminal neuralgia within 24-48 hours. It reduces sustained high-frequency repetitive neural firing and is a potent enzyme inducer that can induce own metabolism. Because of the risk of potentially serious blood dyscrasias, a benefit-to-risk evaluation should be undertaken before drug administration is initiated. 

Therapeutic plasma levels are between 4 and 12 µg/mL for analgesic and antiseizure response. Peak serum levels are reached in 4-5 hours. The serum half-life is 12-17 hours with repeated doses. Carbamazepine is metabolized in the liver to its active metabolite (ie, epoxide derivative) with a half-life of 5-8 hours. Metabolites are excreted via feces and urine.

Oxcarbazepine (Trileptal, Oxtellar XR)

The pharmacologic activity of oxcarbazepine is primarily exerted by the 10-monohydroxy metabolite (MHD). Studies indicate that this drug may block voltage-sensitive sodium channels, inhibiting repetitive neuronal firing and impairing synaptic impulse propagation. The anticonvulsant effect also may occur by affecting potassium conductance, and high-voltage activated calcium channels. 

Pharmacokinetics are similar in older children (>8 years) and adults; young children (< 8 years) have 30-40% greater clearance than older children and adults. Children younger than two years have not been studied in controlled clinical trials. Oxcarbazepine is not FDA-approved for this indication.