Cluster Headache Questions & Answers

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Questions & Answers

Overview

What is cluster headache (CH)?

What are the classifications of cluster headache (CH)?

What is the pathophysiology of cluster headache (CH)?

What is the role of neural circuits in the pathophysiology of cluster headache (CH)?

What is the role of substance P neurons in the pathogenesis of cluster headache (CH)?

What role does vascular dilation play in the pathogenesis of cluster headache (CH)?

What effect do histamines have on cluster headache (CH)?

What causes cluster headache (CH)?

Which factors may provoke cluster headache (CH)?

What are risk factors for cluster headache (CH)?

What is the prevalence of cluster headache (CH) in the US?

How does the prevalence of cluster headache (CH) vary by age?

How does the prevalence of cluster headache (CH) vary between men and women?

How does the prevalence of cluster headache (CH) vary by race or ethnicity?

What is the prognosis of cluster headache (CH)?

What is the frequency of progression of chronic cluster headache (CH)?

What are the common comorbidities of cluster headache (CH)?

How does pharmacologic intervention affect the prognosis of cluster headache (CH)?

What information about cluster headache (CH) should patients receive?

Presentation

What are the signs and symptoms of cluster headache (CH)?

How does the International Headache Society (IHS) classify episodic and chronic cluster headache (CH)?

How is the pain of cluster headache (CH) characterized?

Which parasympathetic symptoms accompany pain from cluster headache (CH)?

What are some triggers that precipitate cluster headache (CH)?

What are possible behaviors manifested during a cluster headache (CH) attack?

What are atypical features of cluster headache (CH)?

Which physical findings suggest cluster headache (CH)?

Which physical findings are characteristic of cluster headache (CH)?

What actions do patients with cluster headache (CH) take to relieve severe pain?

DDX

Which conditions should be included in the differential diagnosis of cluster headache (CH)?

What are the differential diagnoses for Cluster Headache?

Workup

How is cluster headache (CH) diagnosed?

Treatment

What are the pharmacologic treatment options for cluster headache (CH)?

What is the role of surgical intervention in the treatment of cluster headache (CH)?

What guidelines are available for the treatment of cluster headache (CH)?

How is cluster headache (CH) treated during pregnancy?

What is the role of abortive agents in the treatment of cluster headache (CH)?

What is the role of oxygen in the treatment of cluster headache (CH)?

What is the first line of treatment for cluster headache (CH)?

What is the role of triptans in the treatment of cluster headache (CH)?

What is the role of dihydroergotamine in the treatment of cluster headache (CH)?

What is the role of narcotics and analgesics in the treatment of cluster headache (CH)?

What is the role of intranasal treatments for cluster headache (CH)?

What is the role of calcium channel blockers in the treatment of cluster headache (CH)?

What is the role of lithium in the treatment of cluster headache (CH)?

What is the role of methysergide in the treatment of cluster headache (CH)?

What is the role of anticonvulsants in the treatment of cluster headache (CH)?

What is the role of corticosteroids in the treatment of cluster headache (CH)?

What is the role of tricyclic antidepressants in the treatment of cluster headache (CH)?

What is the role of invasive nerve block and ablative neurosurgical procedures in the treatment of cluster headache (CH)?

What is the role of percutaneous radiofrequency (RF) ablation in the treatment of cluster headache (CH)?

What is the role of deep brain stimulation in the treatment of cluster headache (CH)?

What is the role of stimulation of the sphenopalatine ganglion in the treatment of cluster headache (CH)?

What is the role of vagus nerve stimulation in the treatment of cluster headache (CH)?

How is cluster headache (CH) prevented?

Medications

What are the pharmacologic management options for cluster headache (CH)?

What is the efficacy of high-flow concentrated oxygen in the treatment of cluster headache (CH)?

Which medications in the drug class Antiemetics and Sedatives are used in the treatment of Cluster Headache?

Which medications in the drug class Corticosteroids are used in the treatment of Cluster Headache?

Which medications in the drug class Anticonvulsants are used in the treatment of Cluster Headache?

Which medications in the drug class Psychiatry Agents, Other are used in the treatment of Cluster Headache?

Which medications in the drug class Calcium Channel Blockers are used in the treatment of Cluster Headache?

Which medications in the drug class Analgesics, Topical are used in the treatment of Cluster Headache?

Which medications in the drug class Anesthetics, Topical are used in the treatment of Cluster Headache?

Which medications in the drug class Ergot Derivatives are used in the treatment of Cluster Headache?

Which medications in the drug class CGRP Monoclonal Antibodies are used in the treatment of Cluster Headache?

Which medications in the drug class Neurologics, Other are used in the treatment of Cluster Headache?

Which medications in the drug class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are used in the treatment of Cluster Headache?