Postherpetic Neuralgia Clinical Presentation

1. Gilden D, Nagel MA, Mahalingam R, et al. Clinical and molecular aspects of varicella zoster virus infection. Future Neurol. 2009 Jan 1. 4(1):103-117. [QxMD MEDLINE Link]. [Full Text].

2. Spiegel R, Miron D, Lumelsky D, Horovitz Y. Severe Meningoencephalitis Due to Late Reactivation of Varicella-Zoster Virus in an Immunocompetent Child. J Child Neurol. 2009 Jun 3. [QxMD MEDLINE Link].

3. Hicks LD, Cook-Norris RH, Mendoza N, Madkan V, Arora A, Tyring SK. Family history as a risk factor for herpes zoster: a case-control study. Arch Dermatol. 2008 May. 144(5):603-8. [QxMD MEDLINE Link].

4. Helgason S, Petursson G, Gudmundsson S, Sigurdsson JA. Prevalence of postherpetic neuralgia after a first episode of herpes zoster: prospective study with long term follow up. BMJ. 2000 Sep 30. 321(7264):794-6. [QxMD MEDLINE Link].

5. Delaney A, Colvin LA, Fallon MT, et al. Postherpetic neuralgia: from preclinical models to the clinic. Neurotherapeutics. 2009 Oct. 6(4):630-7. [QxMD MEDLINE Link].

6. Haanpaa M, Dastidar P, Weinberg A, et al. CSF and MRI findings in patients with acute herpes zoster. Neurology. 1998 Nov. 51(5):1405-11. [QxMD MEDLINE Link].

7. Dworkin RH, White R, O'Connor AB, Hawkins K. Health care expenditure burden of persisting herpes zoster pain. Pain Med. 2008 Apr. 9(3):348-53. [QxMD MEDLINE Link].

8. Brisson M. Estimating the number needed to vaccinate to prevent herpes zoster-related disease, health care resource use and mortality. Can J Public Health. 2008 Sep-Oct. 99(5):383-6. [QxMD MEDLINE Link].

9. Schmader K, Levin M, Gnann J, McNeil S, Vesikari T, et al. Efficacy, immunogenicity, safety, and tolerability of zoster vaccine (ZV) in subjects 50 to 59 years of age (Poster/Abstract). Infectious Diseases Society of America. The 48th Annual Meeting of the Infectious Diseases Society of America. 10-21-2010. Vancouver, British Columbia, Canada:Ref Type: Abstract: 3363.

10. Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang SJ, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May 28. 372 (22):2087-96. [QxMD MEDLINE Link]. [Full Text].

11. Cunningham AL,et al. Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older. N Engl J Med. 2016 Sep 15. 375 (11):1019-32. [QxMD MEDLINE Link]. [Full Text].

12. Shingles (herpes zoster): Vaccination. Centers for Disease Control and Prevention. Available at https://www.cdc.gov/shingles/vaccination.html. 2022; Accessed: September 18, 2023.

13. Chen JY, Chang CY, Feng PH, Chu CC, So EC, Hu ML. Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. Clin J Pain. 2009 Sep. 25(7):562-9. [QxMD MEDLINE Link].

14. Kanai A, Okamoto T, Suzuki K, Niki Y, Okamoto H. Lidocaine eye drops attenuate pain associated with ophthalmic postherpetic neuralgia. Anesth Analg. 2010 May 1. 110(5):1457-60. [QxMD MEDLINE Link].

15. Benzon HT, Chekka K, Darnule A, Chung B, Wille O, Malik K. Evidence-based case report: the prevention and management of postherpetic neuralgia with emphasis on interventional procedures. Reg Anesth Pain Med. 2009 Sep-Oct. 34(5):514-21. [QxMD MEDLINE Link].

16. Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Lancet. 2009 Oct 10. 374(9697):1252-61. [QxMD MEDLINE Link].

17. Irving GA, Backonja M, Rauck R, Webster LR, Tobias JK, Vanhove GF. NGX-4010, a Capsaicin 8% Dermal Patch, Administered Alone or in Combination With Systemic Neuropathic Pain Medications, Reduces Pain in Patients With Postherpetic Neuralgia. Clin J Pain. 2011 Jul 12. [QxMD MEDLINE Link].

18. Baron R, Saguer M. Mechanical allodynia in postherpetic neuralgia: evidence for central mechanisms depending on nociceptive C-fiber degeneration. Neurology. 1995 Dec. 45(12 Suppl 8):S63-5. [QxMD MEDLINE Link].

19. Bowsher D. The management of postherpetic neuralgia. Postgrad Med J. 1997 Oct. 73(864):623-9. [QxMD MEDLINE Link].

20. Choo PW, Galil K, Donahue JG, et al. Risk factors for postherpetic neuralgia. Arch Intern Med. 1997 Jun 9. 157(11):1217-24. [QxMD MEDLINE Link].

21. Freynhagen R, Strojek K, Griesing T, et al. Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain. 2005 Jun. 115(3):254-63. [QxMD MEDLINE Link].

22. Johnson RW. Herpes zoster and postherpetic neuralgia. Optimal treatment. Drugs Aging. 1997 Feb. 10(2):80-94. [QxMD MEDLINE Link].

23. Kotani N, Kushikata T, Hashimoto H, et al. Intrathecal methylprednisolone for intractable postherpetic neuralgia. N Engl J Med. 2000 Nov 23. 343(21):1514-9. [QxMD MEDLINE Link].

24. Merritt HH. A Textbook of Neurology. 1979. 90.

25. Nurmikko T. Clinical features and pathophysiologic mechanisms of postherpetic neuralgia. Neurology. 1995 Dec. 45(12 Suppl 8):S54-5. [QxMD MEDLINE Link].

26. Oxman MN, Levin MJ, Johnson GR, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005 Jun 2. 352(22):2271-84. [QxMD MEDLINE Link].

27. Rath SA, Braun V, Soliman N, et al. Results of DREZ coagulations for pain related to plexus lesions, spinal cord injuries and postherpetic neuralgia. Acta Neurochir (Wien). 1996. 138(4):364-9. [QxMD MEDLINE Link].

28. Rowbotham M, Harden N, Stacey B, et al. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA. 1998 Dec 2. 280(21):1837-42. [QxMD MEDLINE Link].

29. Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel relieves postherpetic neuralgia. Ann Neurol. 1995 Feb. 37(2):246-53. [QxMD MEDLINE Link].

30. Tyring S, Barbarash RA, Nahlik JE, et al. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med. 1995 Jul 15. 123(2):89-96. [QxMD MEDLINE Link].

31. Watson CP. Postherpetic neuralgia. Neurol Clin. 1989 May. 7(2):231-48. [QxMD MEDLINE Link].

32. Watson CP, Vernich L, Chipman M, Reed K. Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. Neurology. 1998 Oct. 51(4):1166-71. [QxMD MEDLINE Link].

33. Watson CPN, Gershon AA. Herpes Zoster and Post Herpetic Neuralgia. Vol 11. 2001:90-93, 108-109.

34. Whitley RJ, Shukla S, Crooks RJ. The identification of risk factors associated with persistent pain following herpes zoster. J Infect Dis. 1998 Nov. 178 Suppl 1:S71-5. [QxMD MEDLINE Link].

W Alvin McElveen, MD Director, Stroke Unit, Lakewood Ranch Medical Center; Neurologist, Manatee Memorial Hospital

W Alvin McElveen, MD is a member of the following medical societies: American Academy of Neurology, Southern Clinical Neurological Society, American Stroke Association, American Medical Association, American Society of Neuroimaging

Disclosure: Nothing to disclose.

Douglas Sinclair, DO Consulting Staff, Department of Neurology, Blake Medical Center and Bradenton Neurology, Inc

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Robert A Egan, MD NW Neuro-Ophthalmology

Robert A Egan, MD is a member of the following medical societies: American Academy of Neurology, American Heart Association, North American Neuro-Ophthalmology Society, Oregon Medical Association

Disclosure: Received honoraria from Biogen Idec and Genentech for participation on Advisory Boards.

Joseph Carcione, Jr, DO, MBA Consultant in Neurology and Medical Acupuncture, Medical Management and Organizational Consulting, Central Westchester Neuromuscular Care, PC; Medical Director, Oxford Health Plans

Joseph Carcione, Jr, DO, MBA is a member of the following medical societies: American Academy of Neurology

Disclosure: Nothing to disclose.

Ralph F Gonzalez, MD Private Practice, Bradenton Neurology, Inc; Consulting Staff, Department of Neurology, Blake Hospital, Lakewood Ranch Medical Center, Manatee Memorial Hospital

Ralph F Gonzalez, MD is a member of the following medical societies: American Academy of Neurology and Florida Medical Association

Disclosure: Nothing to disclose.

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