Marchiafava-Bignami Disease Differential Diagnoses

Updated: Oct 12, 2016
  • Author: Jennifer L Ault, DO, DPT; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Diagnostic Considerations

The corpus callosum may also be affected in other diseases, such as ischemic stroke, contusion, lymphoma, and multiple sclerosis. However, Marchiafava-Bignami disease (MBD) is distinguished by callosal lesions that are usually symmetrical and located in the middle of the corpus callosum.

Other conditions to consider in the differential diagnosis o MBD include the following:

  • Paraneoplastic encephalomyelitis

  • Pick disease

  • Status epilepticus

  • Tonic-clonic seizures

Differential Diagnoses