Marchiafava-Bignami Disease Medication

Updated: Jun 27, 2017
  • Author: Cortney Lyford, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Medication

Vitamins, Water-Soluble

Class Summary

Improvement has been seen in the small number of individual patients who received treatments that included at least 1 agent in this drug category.

Thiamine

Thiamine is a water-soluble vitamin that combines with adenosine triphosphate to form the coenzyme thiamine pyrophosphate, which is necessary for carbohydrate metabolism. The B vitamins are readily absorbed from the gastrointestinal (GI) tract (except in cases of malabsorption syndromes). Alcohol inhibits the absorption of thiamine, which occurs primarily in the duodenum.

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Immunosuppressants

Class Summary

Improvement has been seen in the small number of individual patients who received treatments that included at least 1 agent in this drug category.

Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol)

Methylprednisolone may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear (PMN) leukocyte activity.

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Antiparkinson Agents

Class Summary

Improvement has been seen in the small number of individual patients who received treatments that included at least 1 agent in this drug category.

Amantadine

Amantadine inhibits N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine release in rat striatum. Amantadine may enhance dopamine release, inhibit dopamine reuptake, stimulate postsynaptic dopamine receptors, or enhance dopamine receptor sensitivity.

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