Neurosarcoidosis Questions & Answers

1. Hebel R, Dubaniewicz-Wybieralska M, Dubaniewicz A. Overview of neurosarcoidosis: recent advances. J Neurol. 2015 Feb. 262 (2):258-67. [QxMD MEDLINE Link].

2. Voorter CE, Drent M, Hoitsma E, Faber KG, van den Berg-Loonen EM. Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Jun. 22(2):129-32. [QxMD MEDLINE Link].

3. Desestret V, Didelot A, Meyronet D, Bruyas A, Jouvet A, Honnorat J. Neurosarcoidosis with diencephalitis and anti-Ma2 antibodies. Neurology. 2010 Mar 2. 74(9):772-4. [QxMD MEDLINE Link].

4. Kobayashi D, Rouster-Stevens K, Harper A. La crosse virus encephalitis preceding neurosarcoidosis diagnosed by brain biopsy. Pediatrics. 2011 Apr. 127(4):e1091-6. [QxMD MEDLINE Link].

5. Motta M, Alongi F, Bolognesi A, Cozzarini C, Di Muzio N, Fazio F. Remission of refractory neurosarcoidosis treated with brain radiotherapy: a case report and a literature review. Neurologist. 2008 Mar. 14(2):120-4. [QxMD MEDLINE Link].

6. Joseph FG, Scolding NJ. Neurosarcoidosis: a study of 30 new cases. J Neurol Neurosurg Psychiatry. 2009 Mar. 80(3):297-304. [QxMD MEDLINE Link].

7. Allen RK, Sellars RE, Sandstrom PA. A prospective study of 32 patients with neurosarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun. 20(2):118-25. [QxMD MEDLINE Link].

8. Byard RW, Manton N, Tsokos M. Sarcoidosis and mechanisms of unexpected death. J Forensic Sci. 2008 Mar. 53(2):460-4. [QxMD MEDLINE Link].

9. Petropoulos IK, Zuber JP, Guex-Crosier Y. Heerfordt syndrome with unilateral facial nerve palsy: a rare presentation of sarcoidosis. Klin Monbl Augenheilkd. 2008 May. 225(5):453-6. [QxMD MEDLINE Link].

10. Niemer GW, Bolster MB, Buxbaum L, Judson MA. Carpal tunnel syndrome in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2001 Oct. 18(3):296-300. [QxMD MEDLINE Link].

11. SHAMBAUGH GE, CIRKSENA WJ, NEWCOMER KL. CARPAL TUNNEL SYNDROME AS MANIFESTATION OF SARCOIDOSIS. Arch Intern Med. 1964 Dec. 114:830-3. [QxMD MEDLINE Link].

12. Nakatani-Enomoto S, Aizawa H, Koyama S, Kuroda K, Kimura T, Kikuchi K. Transient swelling of peripheral nerves in a case of neurosarcoidosis. Intern Med. 2004 Nov. 43(11):1078-81. [QxMD MEDLINE Link].

13. Colvin IB. Audiovestibular manifestations of sarcoidosis: a review of the literature. Laryngoscope. 2006 Jan. 116(1):75-82. [QxMD MEDLINE Link].

14. Burns TM, Dyck PJ, Aksamit AJ, Dyck PJ. The natural history and long-term outcome of 57 limb sarcoidosis neuropathy cases. J Neurol Sci. 2006 May 15. 244(1-2):77-87. [QxMD MEDLINE Link].

15. Brigger MT, McLeod IK, Sorensen MP. Neurosarcoidosis presenting as complicated sinusitis: a case report and review. Ear Nose Throat J. 2008 Feb. 87(2):93-5. [QxMD MEDLINE Link].

16. Parthasarathy K, Wu J, Vigneswaran N. Oral and maxillofacial pathology case of the month. Neurosarcoidosis. Tex Dent J. 2010 Aug. 127(8):786-9. [QxMD MEDLINE Link].

17. Miura S, Kusumoto M, Noda K, Azuma K, Toda R, Honda S, et al. Bell-shaped sensory impairments of all modalities in a neurosarcoidosis patient. Clin Neurol Neurosurg. 2007 Nov. 109(9):794-8. [QxMD MEDLINE Link].

18. Nakazato Y, Kondo S, Ohkuma A, Ito Y, Tamura N, Araki N. Neurosarcoidosis presenting as spontaneously remitting hypersomnia. J Neurol. 2009 Nov. 256(11):1929-31. [QxMD MEDLINE Link].

19. Afshar K, Engelfried K, Sharma OP. Sarcoidosis: a rare cause of Kleine-Levine-Critchley syndrome. Sarcoidosis Vasc Diffuse Lung Dis. 2008 Sep. 25(1):60-3. [QxMD MEDLINE Link].

20. Papapetropoulos S, Guevara A, Georgiou M, Mitsi G, Singer C, Delgado S. Sarcoidosis with basal ganglial infiltration presenting as Parkinsonism. BMJ Case Rep. 2009. 2009:[QxMD MEDLINE Link]. [Full Text].

21. Lee CH, Jung YS, Lee SH. Hydrocephalus as a presenting manifestation of neurosarcoidosis : easy to misdiagnose as tuberculosis. J Korean Neurosurg Soc. 2010 Jul. 48(1):79-81. [QxMD MEDLINE Link]. [Full Text].

22. D'Errico S, Bello S, Cantatore S, Neri M, Riezzo I, Turillazzi E, et al. Immunohistochemical characterisation and TNF-a expression of the granulomatous infiltration of the brainstem in a case of sudden death due to neurosarcoidosis. Forensic Sci Int. 2011 May 20. 208(1-3):e1-5. [QxMD MEDLINE Link].

23. Hoitsma E, Faber CG, van Kroonenburgh MJ, Gorgels AP, Halders SG, Heidendal GA, et al. Association of small fiber neuropathy with cardiac sympathetic dysfunction in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Mar. 22(1):43-50. [QxMD MEDLINE Link].

24. Zoja R, Andreola S, Gentile G, Rancati A. Sudden death from systemic sarcoidosis: a case of legal medicine. Sarcoidosis Vasc Diffuse Lung Dis. 2012 Mar. 29(1):62-8. [QxMD MEDLINE Link].

25. Uzawa A, Kojima S, Yonezu T, Kanesaka T. Truncal polyradiculopathy due to sarcoidosis. J Neurol Sci. 2009 Jun 15. 281(1-2):108-9. [QxMD MEDLINE Link].

26. Jain V, Deshmukh A, Gollomp S. Bilateral facial paralysis: case presentation and discussion of differential diagnosis. J Gen Intern Med. 2006 Jul. 21(7):C7-10. [QxMD MEDLINE Link]. [Full Text].

27. Mañá J, Gámez C. Molecular imaging in sarcoidosis. Curr Opin Pulm Med. 2011 Sep. 17(5):325-31. [QxMD MEDLINE Link].

28. Kim SK, Im HJ, Kim W, Kim TS, Hwangbo B, Kim HJ. F-18 fluorodeoxyglucose and F-18 fluorothymidine positron emission tomography/computed tomography imaging in a case of neurosarcoidosis. Clin Nucl Med. 2010 Feb. 35(2):67-70. [QxMD MEDLINE Link].

29. Petereit HF, Reske D, Tumani H, et al. Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis. J Neurol. 2010 Nov. 257(11):1855-63. [QxMD MEDLINE Link].

30. Eckstein C, Saidha S, Sotirchos ES, Byraiah G, Seigo M, Stankiewicz A, et al. Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography. J Neurol. 2012 Jul. 259(7):1390-8. [QxMD MEDLINE Link].

31. Bos MM, Overeem S, van Engelen BG, Scheffer H, van den Elzen C, Ter Laak H, et al. A case of neuromuscular mimicry. Neuromuscul Disord. 2006 Aug. 16(8):510-3. [QxMD MEDLINE Link].

32. Nemni R, Galassi G, Cohen M, Hays AP, Gould R, Singh N, et al. Symmetric sarcoid polyneuropathy: analysis of a sural nerve biopsy. Neurology. 1981 Oct. 31(10):1217-23. [QxMD MEDLINE Link].

33. Vital A, Lagueny A, Ferrer X, Louiset P, Canron MH, Vital C. Sarcoid neuropathy: clinico-pathological study of 4 new cases and review of the literature. Clin Neuropathol. 2008 Mar-Apr. 27(2):96-105. [QxMD MEDLINE Link].

34. Said G, Lacroix C, Planté-Bordeneuve V, Le Page L, Pico F, Presles O, et al. Nerve granulomas and vasculitis in sarcoid peripheral neuropathy: a clinicopathological study of 11 patients. Brain. 2002 Feb. 125:264-75. [QxMD MEDLINE Link].

35. Levy Y, Uziel Y, Zandman G, Rotman P, Amital H, Sherer Y, et al. Response of vasculitic peripheral neuropathy to intravenous immunoglobulin. Ann N Y Acad Sci. 2005 Jun. 1051:779-86. [QxMD MEDLINE Link].

36. Santos E, Shaunak S, Renowden S, Scolding NJ. Treatment of refractory neurosarcoidosis with Infliximab. J Neurol Neurosurg Psychiatry. 2010 Mar. 81(3):241-6. [QxMD MEDLINE Link].

37. Pereira J, Anderson NE, McAuley D, Bergin P, Kilfoyle D, Fink J. Medically refractory neurosarcoidosis treated with infliximab. Intern Med J. 2011 Apr. 41(4):354-7. [QxMD MEDLINE Link].

38. Moravan M, Segal BM. Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil. Neurology. 2009 Jan 27. 72(4):337-40. [QxMD MEDLINE Link]. [Full Text].

39. Bomprezzi R, Pati S, Chansakul C, Vollmer T. A case of neurosarcoidosis successfully treated with rituximab. Neurology. 2010 Aug 10. 75(6):568-70. [QxMD MEDLINE Link].

40. Androdias G, Maillet D, Marignier R, et al. Mycophenolate mofetil may be effective in CNS sarcoidosis but not in sarcoid myopathy. Neurology. 2011 Mar 29. 76(13):1168-72. [QxMD MEDLINE Link].

41. Hammond ER, Kaplin AI, Kerr DA. Thalidomide for acute treatment of neurosarcoidosis. Spinal Cord. 2007 Dec. 45(12):802-3. [QxMD MEDLINE Link].

42. Hoitsma E, Faber CG, van Santen-Hoeufft M, De Vries J, Reulen JP, Drent M. Improvement of small fiber neuropathy in a sarcoidosis patient after treatment with infliximab. Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar. 23(1):73-7. [QxMD MEDLINE Link].

43. Hostettler KE, Studler U, Tamm M, Brutsche MH. Long-Term Treatment with Infliximab in Patients with Sarcoidosis. Respiration. 2011 Jul 29. [QxMD MEDLINE Link].

44. Chintamaneni S, Patel AM, Pegram SB, Patel H, Roppelt H. Dramatic response to infliximab in refractory neurosarcoidosis. Ann Indian Acad Neurol. 2010 Jul. 13(3):207-10. [QxMD MEDLINE Link]. [Full Text].

45. Sundaresan P, Jayamohan J. Stereotactic radiotherapy for the treatment of neurosarcoidosis involving the pituitary gland and hypothalamus. J Med Imaging Radiat Oncol. 2008 Dec. 52(6):622-6. [QxMD MEDLINE Link].

Gabriel Bucurescu, MD, MS Attending Neurologist, Neurology Service, Corporal Michael J Crescenz Veterans Affairs Medical Center

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Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS † Professor Emeritus of Neurology and Psychiatry, Clinical Professor of Medicine, Clinical Professor of Family Medicine, Clinical Professor of Neurosurgery, State University of New York Upstate Medical University; Neuroscience Director, Department of Neurology, Crouse Irving Memorial Hospital

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