Corticobasal Syndrome and Corticobasal Degeneration Follow-up

Updated: Dec 04, 2019
  • Author: Alexander Pantelyat, MD; Chief Editor: Selim R Benbadis, MD  more...
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Follow-up

Further Outpatient Care

Periodic follow-up is appropriate to adjust dopaminergic medications, levetiracetam or clonazepam for myoclonus, inject botulinu toxin for dystonia or sialorrhea, treat depression/anxiety or other conditions. It may also help the caregiver to make plans for future care as the patient becomes more disabled.

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Further Inpatient Care

Inpatient admission can facilitate a more rapid diagnostic workup as outlined in the Overview; if deterioration has been rapid with a high degree of suspicion, a brain biopsy may be advisable. 

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Complications

Patients with significanat cerebral atrophy can develop subdural hematoma after a lumbar puncture, a fall, or spontaneously. See list of complications in the Overview section.

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Prognosis

Corticobasal degeneration (CBD) is a progressive disorder, leading to increased cognitive and motor disability. Average course of the disease is about 7 years from symptom onset to death and about 4.6 years from diagnosis to death, although survival beyond 12 years has been reported.

Aspiration pneumonia, urosepsis, traumatic falls with head injury or other complications are the most frequent causes of death. [18]

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Patient Education

A  Social Worker or geriatric case manager can be very helpful in counseling the patient and family about community resources, need for supervision, etc. CurePSP has a free guide for Social Workers and rehabilitation specialists conerning CBD, PSP, and MSA: https://www.psp.org/wp-content/uploads/2016/08/ALLIED-HEALTH-BROCHURE_web.pdf

Information for patients and families, guidelines for rehabilitation, and virtual support groups specific to CBS/CBD can be found at https://www.psp.org/

Additional information from the Institute for Neurological Disorders and Stroke:  https://www.ninds.nih.gov/Disorders/All-Disorders/Corticobasal-Degeneration-Information-Page

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