Progressive Supranuclear Palsy Differential Diagnoses

Updated: Oct 17, 2018
  • Author: Eric R Eggenberger, DO, MS, FAAN; Chief Editor: Selim R Benbadis, MD  more...
  • Print

Diagnostic Considerations

The diagnosis of progressive supranuclear palsy (PSP) is clinical. The key features typically develop over time; although the full-blown picture may be relatively easy to recognize, the early or restricted cases are much more challenging (see Physical Examination).

Misdiagnosis is always a potential medicolegal pitfall, especially in diseases such as PSP, for which objective diagnostic tests are unavailable. Treatable disorders, such as idiopathic Parkinson disease, should be considered. Offering the patient and family a second opinion in the setting of an untreatable fatal illness is always worthy of consideration.

In addition to the conditions listed in the differential diagnosis (see below), other problems to be considered include the following:

Differential Diagnoses