Catatonia Differential Diagnoses

Updated: Mar 01, 2018
  • Author: James Robert Brasic, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
  • Print
DDx

Diagnostic Considerations

In addition to the conditions listed in the differential diagnosis, other problems to be considered include the following:

  • Acute stress disorder

  • Anti-NMDA receptor encephalitis

  • Astrocytoma

  • Autistic disorder [5]

  • Brief reactive psychosis with catatonia

  • Carotid disease

  • Cephalosporin-associated neurotoxicity [69]

  • Cocaine-induced leukoencephalopathy [70]

  • Conversion disorder [71, 72]

  • Delirium

  • Dystonia

  • Encephalopathy - HIV infection

  • Extrapontine myelinolysis

  • Fabry disease

  • Hallervorden-Spatz disease

  • Huntington disease

  • Inherited metabolic disorders

  • Inherited neurometabolic disorders

  • Latah betul [41, 42, 43]

  • Locked-in syndrome

  • Low-grade astrocytoma

  • Major depression, single episode with catatonic features

  • Malignant hyperthermia

  • Manganese neurotoxicity [73]

  • Medication adverse effect - Levetiracetam, zotepine

  • Mega cisterna magna [74]

  • Meningioma

  • Mood disorders

  • Neuroleptic malignant syndrome (NMS)

  • Neurosarcoidosis

  • Neurosyphilis

  • Pantothenate kinase-associated neurodegeneration (PKAN), also known as neurodegeneration with brain iron accumulation 1 (NBIA1), also called Hallervorden-Spatz syndrome

  • Parkinson disease

  • Parkinson-plus syndromes

  • Posttraumatic stress disorder

  • Posterior reversible encephalopathy syndrome [75]

  • Prion disease [36]

  • Progressive multifocal leukoencephalopathy

  • Progressive supranuclear palsy

  • Renal failure [69]

  • Schizophrenia

  • Serotonin syndrome [76] - the serotonin syndrome checklist [77] is a simple tool to assess a patient for evidence of serotonin syndrome

  • Stiff-person syndrome

  • Stupor

  • Subdural hematoma

  • Substance intoxication - Cyclosporine, phencyclidine

  • Syphilis

  • Systemic lupus erythematosus [78]

  • Tay-Sachs disease

  • Thermal injury

  • Torticollis

  • Transplantation of kidney and liver [79]

  • Tuberculosis

  • Vegetative states

  • Von Economo encephalitis

  • Zaghrouta [71, 72]

  • Zolpidem withdrawal [80]

Differential Diagnoses