Leptomeningeal Carcinomatosis Questions & Answers

Updated: Nov 27, 2017
  • Author: Michael J Schneck, MD, MBA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Questions & Answers

Overview

Which studies are performed in the workup of leptomeningeal carcinomatosis (LC)?

How common is leptomeningeal carcinomatosis (LC)?

What are the signs and symptoms of leptomeningeal carcinomatosis (LC)?

How is leptomeningeal carcinomatosis (LC) treated?

What is leptomeningeal carcinomatosis (LC)?

What is the pathophysiology of leptomeningeal carcinomatosis (LC)?

What is the prevalence of leptomeningeal carcinomatosis (LC)?

What is the mortality and morbidity associated with leptomeningeal carcinomatosis (LC)?

Which patient groups are at highest risk for leptomeningeal carcinomatosis (LC)?

Presentation

Which clinical history findings are characteristic of leptomeningeal carcinomatosis (LC)?

Which physical findings are characteristic of leptomeningeal carcinomatosis (LC)?

DDX

Which conditions are included in the differential diagnoses of leptomeningeal carcinomatosis (LC)?

What are the differential diagnoses for Leptomeningeal Carcinomatosis?

Workup

How is leptomeningeal carcinomatosis (LC) diagnosed?

What is the role of imaging studies in the work up of leptomeningeal carcinomatosis (LC)?

What is the role of MRI in the work up of leptomeningeal carcinomatosis (LC)?

What is the role of CT scanning in the work up of leptomeningeal carcinomatosis (LC)?

What is the role of myelography in the workup of leptomeningeal carcinomatosis (LC)?

What is the role of radionuclide studies in the workup of leptomeningeal carcinomatosis (LC)?

What is the role of EMG in the workup of leptomeningeal carcinomatosis (LC)?

What is the role of lab studies in the workup of leptomeningeal carcinomatosis (LC)?

What is the role of lumbar puncture and CSF analysis in the workup of leptomeningeal carcinomatosis (LC)?

Which histologic findings are characteristic of leptomeningeal carcinomatosis (LC)?

How is leptomeningeal carcinomatosis (LC) staged?

Treatment

What are the treatment goals of leptomeningeal carcinomatosis (LC)?

How is leptomeningeal carcinomatosis (LC) treated in patients with lung cancer?

What types of therapies are used in the treatment of leptomeningeal carcinomatosis (LC)?

Which chemotherapy agents are used in the treatment of leptomeningeal carcinomatosis (LC)?

What is the treatment for leptomeningeal carcinomatosis (LC) in patients with a fair response to treatment?

What is the treatment for poor-risk patients with leptomeningeal carcinomatosis (LC)?

Which therapies are under investigation for the treatment of leptomeningeal carcinomatosis (LC)?

What is included in supportive care for leptomeningeal carcinomatosis (LC)?

What is the role of surgery in the treatment of leptomeningeal carcinomatosis (LC)?

Medications

What is the role of medications in the treatment of leptomeningeal carcinomatosis (LC)?

Which medications in the drug class Chemotherapeutic agents are used in the treatment of Leptomeningeal Carcinomatosis?

Follow-up

What is included in inpatient care for leptomeningeal carcinomatosis (LC)?

What causes hydrocephalus in leptomeningeal carcinomatosis (LC)?

What are the possible complications of leptomeningeal carcinomatosis (LC)?

What is the prognosis of leptomeningeal carcinomatosis (LC)?

Where can information about ongoing clinical trials for leptomeningeal carcinomatosis (LC) be found?