Paraneoplastic Encephalomyelitis Follow-up

Updated: Sep 09, 2016
  • Author: David S Liebeskind, MD, FAAN, FAHA, FANA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Follow-up

Further Outpatient Care

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  • Physical therapy
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Further Inpatient Care

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  • Physical therapy
  • Nutritional assessment
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Inpatient & Outpatient Medications

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  • Immunosuppressive medications
  • Anticonvulsants
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Transfer

Rapid diagnosis of paraneoplastic encephalomyelitis (PEM) and evaluation of an underlying malignancy should be conducted at a center with neurologic expertise and diagnostic neuroradiologic modalities available.

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Deterrence/Prevention

Preventive measures, such as smoking cessation, are focused on reducing the incidence of the associated malignancy.

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Complications

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  • Severe neurologic disability or death
  • Infections
  • Deep venous thrombosis
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Prognosis

The clinical course of PEM is unpredictable, although the titer of anti-Hu antibodies has been suggested as a prognostic indicator. Elevated titers have been associated with worse neurologic outcome and death.

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Patient Education

Public education efforts should emphasize the dangers of smoking and increase awareness of paraneoplastic disorders.

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