Anisocoria Differential Diagnoses

1. Levin LA. The perils of PERRLA. Ann Intern Med. 2007 Apr 17. 146(8):615-6. [Medline].

2. Ing E, Ing T, Ing S. Measurement of pupil size with the video screen of an infrared autorefractor. Can J Ophthalmol. 2001 Apr. 36 (3):145-6. [Medline].

3. Fan X, Miles JH, Takahashi N, Yao G. Sex-specific lateralization of contraction anisocoria in transient pupillary light reflex. Invest Ophthalmol Vis Sci. 2009 Mar. 50(3):1137-44. [Medline].

4. Thompson S, Pilley SF. Unequal pupils. A flow chart for sorting out the anisocorias. Surv Ophthalmol. 1976 Jul-Aug. 21(1):45-8. [Medline].

5. Freedman KA, Brown SM. Topical apraclonidine in the diagnosis of suspected Horner syndrome. J Neuroophthalmol. 2005 Jun. 25(2):83-5. [Medline].

6. Martin TJ. Horner's syndrome, Pseudo-Horner's syndrome, and simple anisocoria. Curr Neurol Neurosci Rep. 2007 Sep. 7(5):397-406. [Medline].

7. Kawasaki A, Borruat FX. False negative apraclonidine test in two patients with Horner syndrome. Klin Monbl Augenheilkd. 2008 May. 225(5):520-2. [Medline].

8. Wehbe E, Antoun SA, Moussa J, Nassif I. Transient anisocoria caused by aerosolized ipratropium bromide exposure from an ill-fitting face mask. J Neuroophthalmol. 2008 Sep. 28(3):236-7. [Medline].

9. Andreola B, Piovan A, Da Dalt L, Filippini R, Cappelletti E. Unilateral mydriasis due to Angel's trumpet. Clin Toxicol (Phila). 2008 Apr. 46(4):329-31. [Medline].

10. Gross JR, McClelland CM, Lee MS. An approach to anisocoria. Curr Opin Ophthalmol. 2016 Nov. 27 (6):486-492. [Medline].

11. Steck RP, Kong M, McCray KL, Quan V, Davey PG. Physiologic anisocoria under various lighting conditions. Clin Ophthalmol. 2018. 12:85-89. [Medline].

12. Cremer SA, Thompson HS, Digre KB, Kardon RH. Hydroxyamphetamine mydriasis in Horner's syndrome. Am J Ophthalmol. 1990 Jul 15. 110(1):71-6. [Medline].

13. Harle DE, Wolffsohn JS, Evans BJ. The pupillary light reflex in migraine. Ophthalmic Physiol Opt. 2005 May. 25(3):240-5. [Medline].

14. Kardon RH, Denison CE, Brown CK, Thompson HS. Critical evaluation of the cocaine test in the diagnosis of Horner's syndrome. Arch Ophthalmol. 1990 Mar. 108(3):384-7. [Medline].

15. Lowenfeld IE. The Pupil. Anatomy, Physiology, and Clinical Application. 1993.

16. Miller NR, Newman NJ, eds. Walsh & Hoyt's Clinical Neuro-ophthalmology. 1998. Vol 1:

17. Moster ML, Galiani D, Garfinkle W. False negative hydroxyamphetamine test in horner syndrome caused by acute internal carotid artery dissection. J Neuroophthalmol. 2003 Mar. 23(1):22-3. [Medline].

18. Pishdad GR, Pishdad P, Pishdad R. Pupillary autonomic neuropathy simulating partial Horner syndrome in diabetes mellitus and its reversal with control of blood glucose. J Neuroophthalmol. 2008 Sep. 28(3):241-2. [Medline].

Eric R Eggenberger, DO, MS, FAAN Professor, Vice-Chairman, Department of Neurology and Ophthalmology, Colleges of Osteopathic Medicine and Human Medicine, Michigan State University; Director of Michigan State University Ocular Motility Laboratory; Director of National Multiple Sclerosis Society Clinic, Michigan State University College of Human Medicine

Eric R Eggenberger, DO, MS, FAAN is a member of the following medical societies: American Academy of Neurology, American Academy of Ophthalmology, American Osteopathic Association, North American Neuro-Ophthalmology Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: LifeBlood<br/>Serve(d) as a speaker or a member of a speakers bureau for: Biogen; Genzyme; Novartis; Teva; Mallinckrodt<br/>Received research grant from: Biogen; Genzyme; Novartis<br/>Received consulting fee from Biogen for consulting; Received consulting fee from Teva for consulting; Received consulting fee from Acorda for consulting; Received grant/research funds from Novartis for independent contractor; Received honoraria from Genentech for speaking and teaching; Received honoraria from Genzyme for speaking and teaching.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Jane W Chan, MD Professor of Neurology/Neuro-ophthalmology, Department of Medicine, Division of Neurology, University of Nevada School of Medicine

Jane W Chan, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Ophthalmology, American Medical Association, North American Neuro-Ophthalmology Society, Phi Beta Kappa

Disclosure: Nothing to disclose.

Edsel Ing, MD, MPH, FRCSC Associate Professor, Department of Ophthalmology and Vision Sciences, University of Toronto Faculty of Medicine; Active Staff, Michael Garron Hospital (Toronto East Health Network); Consulting Staff, Hospital for Sick Children and Sunnybrook Hospital, Canada

Edsel Ing, MD, MPH, FRCSC is a member of the following medical societies: American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, American Society of Ophthalmic Plastic and Reconstructive Surgery, Canadian Medical Association, Canadian Ophthalmological Society, Canadian Society of Oculoplastic Surgery, Chinese Canadian Medical Society, European Society of Ophthalmic Plastic and Reconstructive Surgery, North American Neuro-Ophthalmology Society, Ontario Medical Association, Royal College of Physicians and Surgeons of Canada, Statistical Society of Canada

Disclosure: Nothing to disclose.

James Goodwin, MD Associate Professor, Departments of Neurology and Ophthalmology, University of Illinois College of Medicine; Director, Neuro-Ophthalmology Service, University of Illinois Eye and Ear Infirmary

James Goodwin, MD is a member of the following medical societies: American Academy of Neurology, Illinois State Medical Society, North American Neuro-Ophthalmology Society, Royal Society of Medicine

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article