Intracranial Hemorrhage Differential Diagnoses

1. Nishijima DK, Offerman SR, Ballard DW, Vinson DR, Chettipally UK, Rauchwerger AS, et al. Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med. 2012 Jun. 59(6):460-8.e1-7. [QxMD MEDLINE Link]. [Full Text].

2. Hallevi H, Dar NS, Barreto AD, Morales MM, Martin-Schild S, Abraham AT, et al. The IVH score: a novel tool for estimating intraventricular hemorrhage volume: clinical and research implications. Crit Care Med. 2009 Mar. 37(3):969-74, e1. [QxMD MEDLINE Link].

3. Kernan WN, Viscoli CM, Brass LM, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med. 2000 Dec 21. 343(25):1826-32. [QxMD MEDLINE Link].

4. Vespa PM, O'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003 May 13. 60(9):1441-6. [QxMD MEDLINE Link].

5. Woo D, Haverbusch M, Sekar P. Effect of untreated hypertension on hemorrhagic stroke. Stroke. 2004 Jul. 35(7):1703-8. [QxMD MEDLINE Link].

6. Nishijima DK, Offerman SR, Ballard DW, Vinson DR, Chettipally UK, Rauchwerger AS, et al. Risk of traumatic intracranial hemorrhage in patients with head injury and preinjury warfarin or clopidogrel use. Acad Emerg Med. 2013 Feb. 20(2):140-5. [QxMD MEDLINE Link]. [Full Text].

7. Wada R, Aviv RI, Fox AJ, Sahlas DJ, Gladstone DJ, Tomlinson G, et al. CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhage. Stroke. 2007 Apr. 38(4):1257-62. [QxMD MEDLINE Link].

8. Bang OY, Buck BH, Saver JL, Alger JR, Yoon SR, Starkman S, et al. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol. 2007 Aug. 62(2):170-6. [QxMD MEDLINE Link].

9. Nishihara T, Nagata K, Tanaka S. Newly developed endoscopic instruments for the removal of intracerebral hematoma. Neurocrit Care. 2005. 2(1):67-74. [QxMD MEDLINE Link].

10. Mayer SA, Brun NC, Begtrup K. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24. 352(8):777-85. [QxMD MEDLINE Link].

11. Zaaroor M, Soustiel JF, Brenner B, Bar-Lavie Y, Martinowitz U, Levi L. Administration off label of recombinant factor-VIIa (rFVIIa) to patients with blunt or penetrating brain injury without coagulopathy. Acta Neurochir (Wien). 2008 Jul. 150(7):663-8. [QxMD MEDLINE Link].

12. Honner SK, Singh A, Cheung PT, Alter HJ, Dutaret CG, Patel AK, et al. Emergency department control of blood pressure in intracerebral hemorrhage. J Emerg Med. 2011 Oct. 41(4):355-61. [QxMD MEDLINE Link].

13. Bansal S, Blalock D, Kebede T, Dean NP, Carpenter JL. Levetiracetam versus (fos)phenytoin for seizure prophylaxis in pediatric patients with intracranial hemorrhage. J Neurosurg Pediatr. 2014 Feb. 13(2):209-15. [QxMD MEDLINE Link].

14. Taylor S, Heinrichs RJ, Janzen JM, Ehtisham A. Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage. Neurocrit Care. 2011 Aug. 15(1):80-4. [QxMD MEDLINE Link].

15. Qureshi AI, Palesch YY, Martin R, Novitzke J, Cruz-Flores S, Ehtisham A. Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3-month outcome among patients with intracerebral hemorrhage: results from the antihypertensive treatment of acute cerebral hemorrhage study. Arch Neurol. 2010 May. 67(5):570-6. [QxMD MEDLINE Link].

16. Biffi A, Devan WJ, Anderson CD, et al. Statin use and outcome after intracerebral hemorrhage: Case-control study and meta-analysis. Neurology. 2011 May 3. 76(18):1581-8. [QxMD MEDLINE Link].

17. Finelli PF, Kessimian N, Bernstein PW. Cerebral amyloid angiopathy manifesting as recurrent intracerebral hemorrhage. Arch Neurol. 1984 Mar. 41(3):330-3. [QxMD MEDLINE Link].

18. Ritter MA, Droste DW, Hegedus K. Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients. Neurology. 2005 Apr 12. 64(7):1233-7. [QxMD MEDLINE Link].

19. Castellanos M, Leira R, Tejada J. Predictors of good outcome in medium to large spontaneous supratentorial intracerebral haemorrhages. J Neurol Neurosurg Psychiatry. 2005 May. 76(5):691-5. [QxMD MEDLINE Link].

20. Alberts MJ, Latchaw RE, Selman WR. Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke. 2005 Jul. 36(7):1597-616. [QxMD MEDLINE Link].

21. Auer LM, Deinsberger W, Niederkorn K, et al. Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study. J Neurosurg. 1989 Apr. 70(4):530-5. [QxMD MEDLINE Link].

22. Bang OY, Saver JL, Alger JR, Shah SH, Buck BH, Starkman S, et al. Patterns and Predictors of Blood-Brain Barrier Permeability Derangements in Acute Ischemic Stroke. Stroke. 2008 Nov 26. [QxMD MEDLINE Link].

23. Bang OY, Saver JL, Liebeskind DS, Starkman S, Villablanca P, Salamon N, et al. Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis. Neurology. 2007 Mar 6. 68(10):737-42. [QxMD MEDLINE Link].

24. Bradley WG Jr. MR appearance of hemorrhage in the brain. Radiology. 1993 Oct. 189(1):15-26. [QxMD MEDLINE Link].

25. Broderick J, Connolly S, Feldmann E, Hanley D, Kase C, Krieger D, et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke. 2007 Jun. 38(6):2001-23. [QxMD MEDLINE Link].

26. Broderick JP, Brott T, Tomsick T, et al. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 1993 Feb. 78(2):188-91. [QxMD MEDLINE Link].

27. Broderick JP, Brott TG, Tomsick T, et al. Ultra-early evaluation of intracerebral hemorrhage. J Neurosurg. 1990 Feb. 72(2):195-9. [QxMD MEDLINE Link].

28. Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet. 2007 Jan 27. 369(9558):293-8. [QxMD MEDLINE Link].

29. Chiquete E, Ruiz-Sandoval MC, Alvarez-Palazuelos LE, Padilla-Martínez JJ, González-Cornejo S, Ruiz-Sandoval JL. Hypertensive intracerebral hemorrhage in the very elderly. Cerebrovasc Dis. 2007. 24(2-3):196-201. [QxMD MEDLINE Link].

30. Connor MD, Modi G, Warlow CP. Accuracy of the Siriraj and Guy's Hospital Stroke Scores in urban South Africans. Stroke. 2007 Jan. 38(1):62-8. [QxMD MEDLINE Link].

31. Demaerschalk BM, Aguilar MI. Treatment of acute intracerebral hemorrhage. Curr Treat Options Neurol. 2008 Nov. 10(6):455-67. [QxMD MEDLINE Link].

32. Derex L, Nighoghossian N. Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update. J Neurol Neurosurg Psychiatry. 2008 Oct. 79(10):1093-9. [QxMD MEDLINE Link].

33. Fiehler J, Remmele C, Kucinski T. Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation: an MRI study in acute stroke patients. Cerebrovasc Dis. 2005. 19(2):117-24. [QxMD MEDLINE Link].

34. Flemming KD, Wijdicks EF, St Louis EK, Li H. Predicting deterioration in patients with lobar haemorrhages. J Neurol Neurosurg Psychiatry. 1999 May. 66(5):600-5. [QxMD MEDLINE Link].

35. Greenberg SM. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology. 1998 Sep. 51(3):690-4. [QxMD MEDLINE Link].

36. Hankey GJ, Hon C. Surgery for primary intracerebral hemorrhage: is it safe and effective? A systematic review of case series and randomized trials. Stroke. 1997 Nov. 28(11):2126-32. [QxMD MEDLINE Link].

37. Hart RG, Boop BS, Anderson DC. Oral anticoagulants and intracranial hemorrhage. Facts and hypotheses. Stroke. 1995 Aug. 26(8):1471-7. [QxMD MEDLINE Link].

38. Ivascu FA, Howells GA, Junn FS. Rapid warfarin reversal in anticoagulated patients with traumatic intracranial hemorrhage reduces hemorrhage progression and mortality. J Trauma. 2005 Nov. 59(5):1131-7; discussion 1137-9. [QxMD MEDLINE Link].

39. Juvela S, Heiskanen O, Poranen A, et al. The treatment of spontaneous intracerebral hemorrhage. A prospective randomized trial of surgical and conservative treatment. J Neurosurg. 1989 May. 70(5):755-8. [QxMD MEDLINE Link].

40. Kang HS, Han MH, Kwon OK, Kwon BJ, Kim SH, Oh CW. Intracranial hemorrhage after carotid angioplasty: a pooled analysis. J Endovasc Ther. 2007 Feb. 14(1):77-85. [QxMD MEDLINE Link].

41. Kassner A, Roberts T, Taylor K. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol. 2005 Oct. 26(9):2213-7. [QxMD MEDLINE Link].

42. Khatri P, Broderick JP, Khoury JC, Carrozzella JA, Tomsick TA. Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk. Stroke. 2008 Dec. 39(12):3283-7. [QxMD MEDLINE Link].

43. Khatri P, Wechsler LR, Broderick JP. Intracranial hemorrhage associated with revascularization therapies. Stroke. 2007 Feb. 38(2):431-40. [QxMD MEDLINE Link].

44. Kidwell CS, Chalela JA, Saver JL. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA. 2004 Oct 20. 292(15):1823-30. [QxMD MEDLINE Link].

45. Klatsky AL, Friedman GD, Sidney S. Risk of hemorrhagic stroke in Asian American ethnic groups. Neuroepidemiology. 2005. 25(1):26-31. [QxMD MEDLINE Link].

46. Lees KR, Zivin JA, Ashwood T. NXY-059 for acute ischemic stroke. N Engl J Med. 2006 Feb 9. 354(6):588-600. [QxMD MEDLINE Link].

47. Leira R, Davalos A, Silva Y. Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology. 2004 Aug 10. 63(3):461-7. [QxMD MEDLINE Link].

48. Liu-DeRyke X, Rhoney D. Hemostatic therapy for the treatment of intracranial hemorrhage. Pharmacotherapy. 2008 Apr. 28(4):485-95. [QxMD MEDLINE Link].

49. Lo WD, Lee J, Rusin J, Perkins E, Roach ES. Intracranial hemorrhage in children: an evolving spectrum. Arch Neurol. 2008 Dec. 65(12):1629-33. [QxMD MEDLINE Link].

50. Lu A, Tang Y, Ran R. Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab. 2006 Feb. 26(2):230-52. [QxMD MEDLINE Link].

51. Mascitelli L, Pezzetta F, Goldstein MR. Hemorrhagic stroke in the SPARCL study. Stroke. 2008 Nov. 39(11):e180; author reply e181. [QxMD MEDLINE Link].

52. Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol. 2005 Oct. 4(10):662-72. [QxMD MEDLINE Link].

53. Mitchell P, Mitra D, Gregson BA, Mendelow AD. Prevention of intracerebral haemorrhage. Curr Drug Targets. 2007 Jul. 8(7):832-8. [QxMD MEDLINE Link].

54. Narayan RK, Maas AI, Marshall LF, Servadei F, Skolnick BE, Tillinger MN. Recombinant factor VIIA in traumatic intracerebral hemorrhage: results of a dose-escalation clinical trial. Neurosurgery. 2008 Apr. 62(4):776-86; discussion 786-8. [QxMD MEDLINE Link].

55. Nghiemphu PL, Green RM, Pope WB, Lai A, Cloughesy TF. Safety of anticoagulation use and bevacizumab in patients with glioma. Neuro Oncol. 2008 Jun. 10(3):355-60. [QxMD MEDLINE Link].

56. Nishijima DK, Dager WE, Schrot RJ, Holmes JF. The efficacy of factor VIIa in emergency department patients with warfarin use and traumatic intracranial hemorrhage. Acad Emerg Med. 2010 Mar. 17(3):244-51. [QxMD MEDLINE Link].

57. Nyquist P. Management of acute intracranial and intraventricular hemorrhage. Crit Care Med. 2010 Mar. 38(3):946-53. [QxMD MEDLINE Link].

58. Ogasawara K, Sakai N, Kuroiwa T, Hosoda K, Iihara K, Toyoda K, et al. Intracranial hemorrhage associated with cerebral hyperperfusion syndrome following carotid endarterectomy and carotid artery stenting: retrospective review of 4494 patients. J Neurosurg. 2007 Dec. 107(6):1130-6. [QxMD MEDLINE Link].

59. Oppenheim C, Touze E, Hernalsteen D. Comparison of five MR sequences for the detection of acute intracranial hemorrhage. Cerebrovasc Dis. 2005. 20(5):388-94. [QxMD MEDLINE Link].

60. Orakcioglu B, Becker K, Sakowitz OW, Unterberg A, Schellinger PD. Serial diffusion and perfusion MRI analysis of the perihemorrhagic zone in a rat ICH model. Acta Neurochir Suppl. 2008. 103:15-8. [QxMD MEDLINE Link].

61. Prasad K, Mendelow AD, Gregson B. Surgery for primary supratentorial intracerebral haemorrhage. Cochrane Database Syst Rev. 2008 Oct 8. CD000200. [QxMD MEDLINE Link].

62. Qureshi AI, Mohammad YM, Yahia AM. A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med. 2005 Jan-Feb. 20(1):34-42. [QxMD MEDLINE Link].

63. Qureshi AI, Suri MF. Acute reversal of clopidogrel-related platelet inhibition using methyl prednisolone in a patient with intracranial hemorrhage. AJNR Am J Neuroradiol. 2008 Nov. 29(10):e97. [QxMD MEDLINE Link].

64. Rincon F, Mayer SA. Current treatment options for intracerebral hemorrhage. Curr Treat Options Cardiovasc Med. 2008 Jun. 10(3):229-40. [QxMD MEDLINE Link].

65. Rincon F, Mayer SA. Intracerebral hemorrhage: getting ready for effective treatments. Curr Opin Neurol. 2010 Feb. 23(1):59-64. [QxMD MEDLINE Link].

66. Runchey S, McGee S. Does this patient have a hemorrhagic stroke?: clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010 Jun 9. 303(22):2280-6. [QxMD MEDLINE Link].

67. Sandercock P. Yes' or 'no' to routine statins after subarachnoid hemorrhage to prevent delayed cerebral ischaemia, vasospasm, and death? A cautionary tale of 2 meta-analyses. Stroke. 2010 Jan. 41(1):e1-2. [QxMD MEDLINE Link].

68. Smith EE, Rosand J, Greenberg SM. Hemorrhagic stroke. Neuroimaging Clin N Am. 2005 May. 15(2):259-72, ix. [QxMD MEDLINE Link].

69. Sorimachi T, Fujii Y, Morita K, Tanaka R. Predictors of hematoma enlargement in patients with intracerebral hemorrhage treated with rapid administration of antifibrinolytic agents and strict blood pressure control. J Neurosurg. 2007 Feb. 106(2):250-4. [QxMD MEDLINE Link].

70. Steiner T, Rosand J, Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke. 2006 Jan. 37(1):256-62. [QxMD MEDLINE Link].

71. Struffert T, Doelken M, Adamek E, Schwarz M, Engelhorn T, Kloska S, et al. Flat-detector computed tomography with intravenous contrast material application in experimental aneurysms: comparison with multislice CT and conventional angiography. Acta Radiol. 2010 May. 51(4):431-7. [QxMD MEDLINE Link].

72. Tuhrim S, Dambrosia JM, Price TR, et al. Prediction of intracerebral hemorrhage survival. Ann Neurol. 1988 Aug. 24(2):258-63. [QxMD MEDLINE Link].

73. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008 Apr 1. 70(14):1208-14. [QxMD MEDLINE Link].

74. Viswanathan A, Chabriat H. Cerebral microhemorrhage. Stroke. 2006 Feb. 37(2):550-5. [QxMD MEDLINE Link].

75. Zhu XL, Chan MS, Poon WS. Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature. Stroke. 1997 Jul. 28(7):1406-9. [QxMD MEDLINE Link].

David S Liebeskind, MD, FAAN, FAHA, FANA Professor of Neurology and Director, Neurovascular Imaging Research Core, Director, Vascular Neurology Residency Program, Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine; Director, UCLA Outpatient Stroke and Neurovascular Programs; Director, UCLA Cerebral Blood Flow Laboratory; Associate Neurology Director, UCLA Stroke Center

David S Liebeskind, MD, FAAN, FAHA, FANA is a member of the following medical societies: American Academy of Neurology, American Heart Association, American Medical Association, American Society of Neuroimaging, American Society of Neuroradiology, National Stroke Association, Stroke Council of the American Heart Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Howard S Kirshner, MD Professor of Neurology, Psychiatry and Hearing and Speech Sciences, Vice Chairman, Department of Neurology, Vanderbilt University School of Medicine; Director, Vanderbilt Stroke Center; Program Director, Stroke Service, Vanderbilt Stallworth Rehabilitation Hospital; Consulting Staff, Department of Neurology, Nashville Veterans Affairs Medical Center

Howard S Kirshner, MD is a member of the following medical societies: Alpha Omega Alpha, American Neurological Association, American Society of Neurorehabilitation, American Academy of Neurology, American Heart Association, American Medical Association, National Stroke Association, Phi Beta Kappa, Tennessee Medical Association

Disclosure: Nothing to disclose.

Helmi L Lutsep, MD Professor and Vice Chair, Department of Neurology, Oregon Health and Science University School of Medicine; Associate Director, OHSU Stroke Center

Helmi L Lutsep, MD is a member of the following medical societies: American Academy of Neurology, American Stroke Association

Disclosure: Medscape Neurology Editorial Advisory Board for: Stroke Adjudication Committee, CREST2; Physician Advisory Board for Coherex Medical; National Leader and Steering Committee Clinical Trial, Bristol Myers Squibb; Abbott Laboratories, advisory group.

Jeffrey L Saver, MD, FAHA, FAAN Professor of Neurology, Director, UCLA Stroke Center, University of California, Los Angeles, David Geffen School of Medicine

Jeffrey L Saver, MD, FAHA, FAAN is a member of the following medical societies: American Academy of Neurology, American Heart Association, American Neurological Association, National Stroke Association

Disclosure: Received the university of california regents receive funds for consulting services on clinical trial design provided to covidien, stryker, and lundbeck. from University of California for consulting.

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