Status Epilepticus Questions & Answers

1. Lüders HO, Rona S, Rosenow F, et al. A semiological classification of status epilepticus. Epileptic Disord. 2005 Jun. 7(2):149-50. [QxMD MEDLINE Link].

2. [Guideline] Trinka E, Cock H, Hersdorffer D, Rossetti AO, Scheffer IE, Shinnar S, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015. 56(10):1515-1523. [QxMD MEDLINE Link].

3. Brenner RP. EEG in convulsive and nonconvulsive status epilepticus. J Clin Neurophysiol. 2004 Sep-Oct. 21(5):319-31. [QxMD MEDLINE Link].

4. Kaplan PW. The EEG of status epilepticus. J Clin Neurophysiol. 2006 Jun. 23(3):221-9. [QxMD MEDLINE Link].

5. D'Giano CH, Del C Garcia M, Pomata H, Rabinowicz AL. Treatment of refractory partial status epilepticus with multiple subpial transection: case report. Seizure. 2001 Jul. 10(5):382-5. [QxMD MEDLINE Link].

6. Ma X, Liporace J, O'Connor MJ, Sperling MR. Neurosurgical treatment of medically intractable status epilepticus. Epilepsy Res. 2001 Jul. 46(1):33-8. [QxMD MEDLINE Link].

7. Duane DC, Ng YT, Rekate HL, et al. Treatment of refractory status epilepticus with hemispherectomy. Epilepsia. 2004 Aug. 45(8):1001-4. [QxMD MEDLINE Link].

8. Winston KR, Levisohn P, Miller BR, Freeman J. Vagal nerve stimulation for status epilepticus. Pediatr Neurosurg. 2001 Apr. 34(4):190-2. [QxMD MEDLINE Link].

9. Proceedings and abstracts of the First London Colloquium on Status Epilepticus, University College London, April 12-15, 2007. Epilepsia. 2007. 48 Suppl 8:1-109. [QxMD MEDLINE Link].

10. Shorvon SD, Trinka E, Walker MC. The proceedings of the First London Colloquium on Status Epilepticus--University College London, April 12-15, 2007. Introduction. Epilepsia. 2007. 48 Suppl 8:1-3. [QxMD MEDLINE Link].

11. Kälviäinen R. Status epilepticus treatment guidelines. Epilepsia. 2007. 48 Suppl 8:99-102. [QxMD MEDLINE Link].

12. Wilson JV, Reynolds EH. Texts and documents. Translation and analysis of a cuneiform text forming part of a Babylonian treatise on epilepsy. Med Hist. 1990 Apr. 34(2):185-98. [QxMD MEDLINE Link].

13. Wolf P, Trinka E, Bauer G. Absence status epilepticus: the first documented case?. Epilepsia. 2007. 48 Suppl 8:4-5. [QxMD MEDLINE Link].

14. Epilepsy Foundation of America. Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA. 1993 Aug 18. 270(7):854-9. [QxMD MEDLINE Link].

15. Lowenstein DH, Bleck T, Macdonald RL. It's time to revise the definition of status epilepticus. Epilepsia. 1999 Jan. 40(1):120-2. [QxMD MEDLINE Link].

16. Lowenstein DH, Cloyd J. Out-of-hospital treatment of status epilepticus and prolonged seizures. Epilepsia. 2007. 48 Suppl 8:96-8. [QxMD MEDLINE Link].

17. Geier S, Bancaud J, Bonis A, Enjelvin M. [Tele-E.E.G. recordings of three epileptic attacks classified as episodes of PM status (author's transl)]. Rev Electroencephalogr Neurophysiol Clin. 1977 Apr-Jun. 7(2):201-2. [QxMD MEDLINE Link].

18. Ellis JM, Lee SI. Acute prolonged confusion in later life as an ictal state. Epilepsia. 1978 Apr. 19(2):119-28. [QxMD MEDLINE Link].

19. Niedermeyer E, Fineyre F, Riley T, Uematsu S. Absence status (petit mal status) with focal characteristics. Arch Neurol. 1979 Jul. 36(7):417-21. [QxMD MEDLINE Link].

20. Celesia GG. Modern concepts of status epilepticus. JAMA. 1976 Apr 12. 235(15):1571-4. [QxMD MEDLINE Link].

21. Treiman DM. Generalized convulsive, nonconvulsive, and focal status epilepticus. In: Feldman E, ed. Current Diagnosis in Neurology. St. Louis: Mosby-Year Book. 1994:11-8.

22. Lennox W, Lennow MA. Epilepsy and Related Disorders. Boston, MA: Little Brown;. 1960.

23. Cascino GD. Nonconvulsive status epilepticus in adults and children. Epilepsia. 1993. 34 Suppl 1:S21-8. [QxMD MEDLINE Link].

24. Shorvon S. The outcome of tonic-clonic status epilepticus. Curr Opin Neurol. 1994 Apr. 7(2):93-5. [QxMD MEDLINE Link].

25. White PT, Grant P, Mosier J, Craig A. Changes in cerebral dynamics associated with seizures. Neurology. 1961 Apr. 11(4)Pt 1:354-61. [QxMD MEDLINE Link].

26. Aminoff MJ, Simon RP. Status epilepticus. Causes, clinical features and consequences in 98 patients. Am J Med. 1980 Nov. 69(5):657-66. [QxMD MEDLINE Link].

27. Meldrum BS, Horton RW. Physiology of status epilepticus in primates. Arch Neurol. 1973 Jan. 28(1):1-9. [QxMD MEDLINE Link].

28. Naylor DE, Liu H, Wasterlain CG. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci. 2005 Aug 24. 25(34):7724-33. [QxMD MEDLINE Link].

29. Sloviter RS, Zappone CA, Bumanglag AV, Norwood BA, Kudrimoti H. On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy. Epilepsia. 2007. 48 Suppl 8:6-10. [QxMD MEDLINE Link].

30. Goodkin HP, Sun C, Yeh JL, Mangan PS, Kapur J. GABA(A) receptor internalization during seizures. Epilepsia. 2007. 48 Suppl 5:109-13. [QxMD MEDLINE Link].

31. Holmes GL. Influence of brain development on status epilepticus. Epilepsia. 2007. 48 Suppl 8:19-20. [QxMD MEDLINE Link].

32. DeLorenzo RJ, Pellock JM, Towne AR, Boggs JG. Epidemiology of status epilepticus. J Clin Neurophysiol. 1995 Jul. 12(4):316-25. [QxMD MEDLINE Link].

33. Shinnar S, Pellock JM, Moshe SL, et al. In whom does status epilepticus occur: age-related differences in children. Epilepsia. 1997 Aug. 38(8):907-14. [QxMD MEDLINE Link].

34. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996 Apr. 46(4):1029-35. [QxMD MEDLINE Link].

35. Shorvon S. Definition, classification and frequency of status epilepticus. In: Shorvon S, ed. Epilepticus: Its Clinical Features and Treatment in Children and Adults. Cambridge: Cambridge University Press; 1994. 21-33.

36. Rosenow F, Hamer HM, Knake S. The epidemiology of convulsive and nonconvulsive status epilepticus. Epilepsia. 2007. 48 Suppl 8:82-4. [QxMD MEDLINE Link].

37. Lv RJ, Wang Q, Cui T, Zhu F, Shao XQ. Status epilepticus-related etiology, incidence and mortality: A meta-analysis. Epilepsy Research. 2017. 136:12-17. [QxMD MEDLINE Link].

38. Waterhouse EJ, DeLorenzo RJ. Status epilepticus in older patients: epidemiology and treatment options. Drugs Aging. 2001. 18(2):133-42. [QxMD MEDLINE Link].

39. Drislane FW, Blum AS, Lopez MR, Gautam S, Schomer DL. Duration of refractory status epilepticus and outcome: Loss of prognostic utility after several hours. Epilepsia. 2009 Jan 19. [QxMD MEDLINE Link].

40. Rossetti AO, Oddo M, Liaudet L, Kaplan PW. Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology. 2009 Feb 24. 72(8):744-9. [QxMD MEDLINE Link].

41. Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998 Sep 17. 339(12):792-8. [QxMD MEDLINE Link].

42. Thomas P. How urgent is the treatment of nonconvulsive status epilepticus?. Epilepsia. 2007. 48 Suppl 8:44-5. [QxMD MEDLINE Link].

43. Aicardi J, Chevrie JJ. Convulsive status epilepticus in infants and children. A study of 239 cases. Epilepsia. 1970 Jun. 11(2):187-97. [QxMD MEDLINE Link].

44. Lowenstein DH, Alldredge BK. Status epilepticus. N Engl J Med. 1998 Apr 2. 338(14):970-6. [QxMD MEDLINE Link].

45. Hauser WA. Status epilepticus: epidemiologic considerations. Neurology. 1990 May. 40(5 Suppl 2):9-13. [QxMD MEDLINE Link].

46. Boggs JG, Marmarou A, Agnew JP, et al. Hemodynamic monitoring prior to and at the time of death in status epilepticus. Epilepsy Res. 1998 Aug. 31(3):199-209. [QxMD MEDLINE Link].

47. Krumholz A, Sung GY, Fisher RS, Barry E, Bergey GK, Grattan LM. Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology. 1995 Aug. 45(8):1499-504. [QxMD MEDLINE Link].

48. Treiman DM, Walton NY, Kendrick C. A progressive sequence of electroencephalographic changes during generalized convulsive status epilepticus. Epilepsy Res. 1990 Jan-Feb. 5(1):49-60. [QxMD MEDLINE Link].

49. Treiman DM, Meyers PD, Walton NY. DVA Status Epilepticus Cooperative Study Group. Duration of generalized convulsive status epilepticus: relationship to clinical symptomatology and response to treatment. Epilepsia. 1992. 33(Suppl 3):66.

50. Treiman DM. Electroclinical features of status epilepticus. J Clin Neurophysiol. 1995 Jul. 12(4):343-62. [QxMD MEDLINE Link].

51. Bien CG, Elger CE. Epilepsia partialis continua: semiology and differential diagnoses. Epileptic Disord. 2008 Mar. 10(1):3-7. [QxMD MEDLINE Link].

52. Shorvon S, Trinka E. The London-Innsbruck Status Epilepticus Colloquia 2007-2011, and the main advances in the topic of status epilepticus over this period. Epilepsia. 2013. 54 Suppl 6:11-13. [QxMD MEDLINE Link].

53. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011. 134(Pt 10):2802-18. [QxMD MEDLINE Link].

54. Leis AA, Ross MA, Summers AK. Psychogenic seizures: ictal characteristics and diagnostic pitfalls. Neurology. 1992 Jan. 42(1):95-9. [QxMD MEDLINE Link].

55. Jagoda A, Richey-Klein V, Riggio S. Psychogenic status epilepticus. J Emerg Med. 1995 Jan-Feb. 13(1):31-5. [QxMD MEDLINE Link].

56. Holtkamp M, Othman J, Buchheim K, Meierkord H. Diagnosis of psychogenic nonepileptic status epilepticus in the emergency setting. Neurology. 2006 Jun 13. 66(11):1727-9. [QxMD MEDLINE Link].

57. Kutluay E, Beattie J, Passaro EA, Edwards JC, Minecan D, Milling C, et al. Diagnostic and localizing value of ictal SPECT in patients with nonconvulsive status epilepticus. Epilepsy Behav. 2005 Mar. 6(2):212-7. [QxMD MEDLINE Link].

58. Assal F, Papazyan JP, Slosman DO, Jallon P, Goerres GW. SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus?. Seizure. 2001 Jun. 10(4):260-5. [QxMD MEDLINE Link].

59. Karlov VA. Complex partial status epilepticus. Epilepsia. 2007 Sep. 48(9):1815. [QxMD MEDLINE Link].

60. DeLorenzo RJ, Waterhouse EJ, Towne AR, et al. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia. 1998 Aug. 39(8):833-40. [QxMD MEDLINE Link].

61. Szabo K, Poepel A, Pohlmann-Eden B, Hirsch J, Back T, Sedlaczek O, et al. Diffusion-weighted and perfusion MRI demonstrates parenchymal changes in complex partial status epilepticus. Brain. 2005 Jun. 128:1369-76. [QxMD MEDLINE Link].

62. [Guideline] Glauser, T. et al. Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Currents. Jan/Feb 2016. 16(1):48-61. [Full Text].

63. Rossetti AO. Which anesthetic should be used in the treatment of refractory status epilepticus?. Epilepsia. 2007. 48 Suppl 8:52-5. [QxMD MEDLINE Link].

64. Arif H, Hirsch LJ. Treatment of status epilepticus. Semin Neurol. 2008 Jul. 28(3):342-54. [QxMD MEDLINE Link].

65. Parviainen I, Uusaro A, Kalviainen R, et al. Propofol in the treatment of refractory status epilepticus. Intensive Care Med. 2006 Jul. 32(7):1075-9. [QxMD MEDLINE Link].

66. Iyer VN, Hoel R, Rabinstein AA. Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience. Crit Care Med. 2009 Dec. 37(12):3024-30. [QxMD MEDLINE Link].

67. Synowiec AS, Singh DS, Yenugadhati V, Valeriano JP, Schramke CJ, Kelly KM. Ketamine use in the treatment of refractory status epilepticus. Epilepsy Res. 2013 Jan 28. [QxMD MEDLINE Link].

68. Blumkin L, Lerman-Sagie T, Houri T, Gilad E, Nissenkorn A, Ginsberg M, et al. Pediatric refractory partial status epilepticus responsive to topiramate. J Child Neurol. 2005 Mar. 20(3):239-41. [QxMD MEDLINE Link].

69. Prasad M, Krishnan PR, Sequeira R, Al-Roomi K. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev. 2014 Sep 10. 9:CD003723. [QxMD MEDLINE Link].

70. Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 2006 Jul 25. 67(2):340-2. [QxMD MEDLINE Link].

71. Limdi NA, Shimpi AV, Faught E, Gomez CR, Burneo JG. Efficacy of rapid IV administration of valproic acid for status epilepticus. Neurology. 2005 Jan 25. 64(2):353-5. [QxMD MEDLINE Link].

72. Rossetti AO, Bromfield EB. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. Eur Neurol. 2005. 54(1):34-8. [QxMD MEDLINE Link].

73. Patel NC, Landan IR, Levin J, Szaflarski J, Wilner AN. The use of levetiracetam in refractory status epilepticus. Seizure. 2006 Apr. 15(3):137-41. [QxMD MEDLINE Link].

74. Hirsch LJ. Levitating Levetiracetam''s Status for Status Epilepticus. Epilepsy Curr. 2008 Sep-Oct. 8(5):125-6. [QxMD MEDLINE Link]. [Full Text].

75. Bialer M. Clinical pharmacology of parenteral use of antiepileptic drugs. Epilepsia. 2007. 48 Suppl 8:46-8. [QxMD MEDLINE Link].

76. Aggarwal P, Wali JP. Lidocaine in refractory status epilepticus: a forgotten drug in the emergency department. Am J Emerg Med. 1993 May. 11(3):243-4. [QxMD MEDLINE Link].

77. Koubeissi MZ, Mayor CL, Estephan B, Rashid S, Azar NJ. Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus. Acta Neurol Scand. 2011 Feb. 123(2):142-6. [QxMD MEDLINE Link].

78. Costello DJ, Simon MV, Eskandar EN, Frosch MP, Henninger HL, Chiappa KH, et al. Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus. Arch Neurol. 2006 Jun. 63(6):895-901. [QxMD MEDLINE Link].

79. McIntyre J, Robertson S, Norris E, Appleton R, Whitehouse WP, Phillips B, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005 Jul 16-22. 366(9481):205-10. [QxMD MEDLINE Link].

80. de Haan GJ, van der Geest P, Doelman G, Bertram E, Edelbroek P. A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. Epilepsia. 2010 Mar. 51(3):478-82. [QxMD MEDLINE Link].

Julie L Roth, MD Neurologist, Epilepsy and General Neurology, Comprehensive Epilepsy Program, Rhode Island Hospital; Assistant Professor, Department of Neurology, The Warren Alpert Medical School of Brown University

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