Neuroimaging in Neurocysticercosis Medication

Updated: Oct 05, 2016
  • Author: Arturo Carpio, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications.

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Anthelmintics

Class Summary

Parasite biochemical pathways are sufficiently different from the human host to allow selective interference by chemotherapeutic agents in relatively small doses.

Albendazole (Albenza)

Broad-spectrum agent that chemically belongs to benzimidazole group. Has been used to treat enterobiasis, ascariasis, trichuriasis, strongyloidiasis, and hookworm infections, but in US, approved only for use in hydatid disease and neurocysticercosis. Inhibits parasite's ability to assemble tubulin dimers into tubulin polymers, thus arresting microtubule formation. This affects several aspects of parasite's life, including larval development, carbohydrate transport, and enzyme function, as well as maintenance of parasite integument and digestive system.

Praziquantel (Biltricide)

Effective against various trematodes and cestodes including Schistosoma species and tapeworms. Works by increasing parasite's cell membrane permeability. Results in loss of intracellular calcium, massive muscle contractions, and spastic paralysis of parasites, as well as damage to schistosome tegument, followed by attachment of phagocytes to parasite.

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