Variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy Differential Diagnoses

Updated: Feb 24, 2022
  • Author: Florian P Thomas, MD, PhD, MA, MS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Diagnostic Considerations

Because psychiatric symptoms and limb pain are common presenting symptoms in variant Creutzfeldt-Jakob Disease (CJD), a workup for the disease in the early stage may be quite challenging. Therefore, the differential diagnosis includes peripheral neuropathy and a variety of psychiatric disorders.

Earlier age of onset necessitates inclusion of disorders such as Wilson disease in the differential diagnosis. Occurrence of the disease in older patients warrants a search for other conventional causes of dementia. However, sporadic CJD is still the most likely of the differential diagnoses for variant CJD.

Differential Diagnoses