Diabetic Neuropathy Questions & Answers

1. Zeng L, Alongkronrusmee D, van Rijn RM. An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. J Pain Res. 2017 Jan 20. 10:219-228. [QxMD MEDLINE Link]. [Full Text].

2. Bodman MA, Varacallo M. Peripheral Diabetic Neuropathy. StatPearls. 2021 Jan. [QxMD MEDLINE Link]. [Full Text].

3. Carmichael J, Fadavi H, Ishibashi F, Shore AC, Tavakoli M. Advances in Screening, Early Diagnosis and Accurate Staging of Diabetic Neuropathy. Front Endocrinol (Lausanne). 2021. 12:671257. [QxMD MEDLINE Link]. [Full Text].

4. Skyler JS. Diabetic complications. The importance of glucose control. Endocrinol Metab Clin North Am. 1996 Jun. 25(2):243-54. [QxMD MEDLINE Link].

5. Boulton AJ, Malik RA. Diabetic neuropathy. Med Clin North Am. 1998 Jul. 82(4):909-29. [QxMD MEDLINE Link].

6. Juster-Switlyk K, Smith AG. Updates in diabetic peripheral neuropathy. F1000Res. 2016. 5:[QxMD MEDLINE Link]. [Full Text].

7. Bromberg MB. Peripheral neurotoxic disorders. Neurol Clin. 2000 Aug. 18(3):681-94. [QxMD MEDLINE Link].

8. Goetz CG, Pappert EJ. Textbook of Clinical Neurology. Philadelphia: WB Saunders Co; 1999.

9. Pourmand R. Diabetic neuropathy. Neurol Clin. 1997 Aug. 15(3):569-76. [QxMD MEDLINE Link].

10. Sugimoto K, Murakawa Y, Sima AA. Diabetic neuropathy--a continuing enigma. Diabetes Metab Res Rev. 2000 Nov-Dec. 16(6):408-33. [QxMD MEDLINE Link].

11. Vinik AI, Park TS, Stansberry KB, Pittenger GL. Diabetic neuropathies. Diabetologia. 2000 Aug. 43(8):957-73. [QxMD MEDLINE Link].

12. Wilson JD. Williams Textbook of Endocrinology. 9th ed. Philadelphia: WB Saunders Co; 1998.

13. Zochodne DW. Diabetic polyneuropathy: an update. Curr Opin Neurol. 2008 Oct. 21(5):527-33. [QxMD MEDLINE Link].

14. Calcutt NA, Dunn JS. Pain: Nociceptive and Neuropathic Mechanisms. Anesthesiology Clinics of North America.; 1997.

15. Malik RA. Pathology and pathogenesis of diabetic neuropathy. Diabetes Reviews. 1999. 7:253-60.

16. Shigeta H, Yamaguchi M, Nakano K, Obayashi H, Takemura R, Fukui M. Serum autoantibodies against sulfatide and phospholipid in NIDDM patients with diabetic neuropathy. Diabetes Care. 1997 Dec. 20(12):1896-9. [QxMD MEDLINE Link].

17. Tavakkoly-Bazzaz J, Amoli MM, Pravica V, Chandrasecaran R, Boulton AJ, Larijani B. VEGF gene polymorphism association with diabetic neuropathy. Mol Biol Rep. 2010 Mar 30. [QxMD MEDLINE Link].

18. Carrington AL, Litchfield JE. The aldose reductase pathway and nonenzymatic glycation in the pathogenesis of diabetic neuropathy: a critical review for the end of the 20th century. Diabetes Reviews. 1999. 7:275-99.

19. Greene DA, Arezzo JC, Brown MB. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group. Neurology. 1999 Aug 11. 53(3):580-91. [QxMD MEDLINE Link].

20. Ryle C, Donaghy M. Non-enzymatic glycation of peripheral nerve proteins in human diabetics. J Neurol Sci. 1995 Mar. 129(1):62-8. [QxMD MEDLINE Link].

21. Ziegler D, Ametov A, Barinov A, Dyck PJ, Gurieva I, Low PA. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006 Nov. 29(11):2365-70. [QxMD MEDLINE Link].

22. Figueroa-Romero C, Sadidi M, Feldman EL. Mechanisms of disease: The oxidative stress theory of diabetic neuropathy. Rev Endocr Metab Disord. 2008 Dec. 9(4):301-14. [QxMD MEDLINE Link].

23. Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999. 107(7):421-30. [QxMD MEDLINE Link].

24. Apfel SC, Kessler JA, Adornato BT, et al. Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group. Neurology. 1998 Sep. 51(3):695-702. [QxMD MEDLINE Link].

25. Krendel DA, Zacharias A, Younger DS. Autoimmune diabetic neuropathy. Neurol Clin. 1997 Nov. 15(4):959-71. [QxMD MEDLINE Link].

26. Gastol J, Kapusta P, Polus A, et al. Epigenetic mechanism in search for the pathomechanism of diabetic neuropathy development in diabetes mellitus type 1 (T1DM). Endocrine. 2020 Jan 4. [QxMD MEDLINE Link].

27. Groener JB, Jende JME, Kurz FT, et al. Understanding Diabetic Neuropathy: From Subclinical Nerve Lesions to Severe Nerve Fiber Deficits. A Cross-Sectional Study in Patients with Type 2 Diabetes and Healthy Controls. Diabetes. 2019 Dec 11. [QxMD MEDLINE Link].

28. Dorsey RR, Eberhardt MS, Gregg EW, Geiss LS. Control of risk factors among people with diagnosed diabetes, by lower extremity disease status. Prev Chronic Dis. 2009 Oct. 6(4):A114. [QxMD MEDLINE Link]. [Full Text].

29. Diabetes control and complications trial research group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993 Sep 30. 329(14):977-86. [QxMD MEDLINE Link].

30. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am. 1996 Jun. 25(2):325-59. [QxMD MEDLINE Link].

31. Rutkove SB. A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. JAMA. 2009 Oct 7. 302(13):1451-8. [QxMD MEDLINE Link].

32. Finucane TE. Diabetic polyneuropathy and glucose control. JAMA. 2010 Feb 3. 303(5):420; author reply 420-1. [QxMD MEDLINE Link].

33. Boulton AJ, Malik RA. Neuropathy of impaired glucose tolerance and its measurement. Diabetes Care. 2010 Jan. 33(1):207-9. [QxMD MEDLINE Link]. [Full Text].

34. Jende JME, Groener JB, Oikonomou D, et al. Diabetic neuropathy differs between type 1 and type 2 diabetes Insights from magnetic resonance neurography. Ann Neurol. 2018 Feb 14. [QxMD MEDLINE Link].

35. Pai YW, Lin CH, Lee IT, Chang MH. Variability of fasting plasma glucose and the risk of painful diabetic peripheral neuropathy in patients with type 2 diabetes. Diabetes Metab. 2018 Feb 4. [QxMD MEDLINE Link].

36. Altaf QA, Ali A, Piya MK, Raymond NT, Tahrani AA. The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes. J Diabetes Complications. 2016 Jun 2. [QxMD MEDLINE Link].

37. Dabelea D, Stafford JM, Mayer-Davis EJ, et al. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood. JAMA. 2017 Feb 28. 317 (8):825-35. [QxMD MEDLINE Link].

38. Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 1993 Apr. 43(4):817-24. [QxMD MEDLINE Link].

39. Perkins BA, Olaleye D, Bril V. Carpal tunnel syndrome in patients with diabetic polyneuropathy. Diabetes Care. 2002 Mar. 25(3):565-9. [QxMD MEDLINE Link].

40. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Reviews. 1999. 7:245-52.

41. Singh R, Gamble G, Cundy T. Lifetime risk of symptomatic carpal tunnel syndrome in Type 1 diabetes. Diabet Med. 2005 May. 22(5):625-30. [QxMD MEDLINE Link].

42. Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000 Feb. 47(2):123-8. [QxMD MEDLINE Link].

43. Dyck PJ, O'Brien PC. Quantitative sensation testing in epidemiological and therapeutic studies of peripheral neuropathy. Muscle Nerve. 1999 Jun. 22(6):659-62. [QxMD MEDLINE Link].

44. Pirart J. Diabetes mellitus and its degenerative complication: a prospective study of 4,400 patient observed between 1947 and 1973. Diabetes Care. 1978. 1:168-188.

45. Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993 Feb. 36(2):150-4. [QxMD MEDLINE Link].

46. Pan Q, Li Q, Deng W, et al. Prevalence of and Risk Factors for Peripheral Neuropathy in Chinese Patients With Diabetes: A Multicenter Cross-Sectional Study. Front Endocrinol (Lausanne). 2018. 9:617. [QxMD MEDLINE Link]. [Full Text].

47. Moon SS, Kim CH, Kang SM, et al. Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015). Diabetes Metab J. 2021 Jan. 45 (1):115-9. [QxMD MEDLINE Link]. [Full Text].

48. Aaberg ML, Burch DM, Hud ZR, Zacharias MP. Gender differences in the onset of diabetic neuropathy. J Diabetes Complications. 2008 Mar-Apr. 22(2):83-7. [QxMD MEDLINE Link].

49. Mai LM, Clark AJ, Gordon AS, et al. Long-Term Outcomes in the Management of Painful Diabetic Neuropathy. Can J Neurol Sci. 2017 Jan 9. 1-6. [QxMD MEDLINE Link].

50. D'Amato C, Morganti R, Greco C, et al. Diabetic peripheral neuropathic pain is a stronger predictor of depression than other diabetic complications and comorbidities. Diab Vasc Dis Res. 2016 Jun 22. [QxMD MEDLINE Link].

51. Tesfaye S, Watt J, Benbow SJ, Pang KA, Miles J, MacFarlane IA. Electrical spinal-cord stimulation for painful diabetic peripheral neuropathy. Lancet. 1996 Dec 21-28. 348(9043):1698-701. [QxMD MEDLINE Link].

52. Johnson DA, Vinik AI. Gastrointestinal Disturbances. Therapy for Diabetes Mellitus. American Diabetes Association; 1998.

53. Ziegler D. Cardiovascular autonomic neuropathy: clinical manifestations and measurement. Diabetes Reviews. 1999. 7:342-57.

54. Meijer JW, van Sonderen E, Blaauwwiekel EE, et al. Diabetic neuropathy examination: a hierarchical scoring system to diagnose distal polyneuropathy in diabetes. Diabetes Care. 2000 Jun. 23(6):750-3. [QxMD MEDLINE Link].

55. Hokkam EN. Assessment of risk factors in diabetic foot ulceration and their impact on the outcome of the disease. Prim Care Diabetes. 2009 Nov. 3(4):219-24. [QxMD MEDLINE Link].

56. Coppini DV, Wellmer A, Weng C, Young PJ, Anand P, Sönksen PH. The natural history of diabetic peripheral neuropathy determined by a 12 year prospective study using vibration perception thresholds. J Clin Neurosci. 2001 Nov. 8(6):520-4. [QxMD MEDLINE Link].

57. Perkins BA, Olaleye D, Zinman B, Bril V. Simple screening tests for peripheral neuropathy in the diabetes clinic. Diabetes Care. 2001 Feb. 24(2):250-6. [QxMD MEDLINE Link].

58. Dyck PJ, Turner DW, Davies JL, O'Brien PC, Dyck PJ, Rask CA. Electronic case-report forms of symptoms and impairments of peripheral neuropathy. Can J Neurol Sci. 2002 Aug. 29(3):258-66. [QxMD MEDLINE Link].

59. Biaggioni I. Postural hypotension. Therapy for Diabetes Mellitus. American Diabetes Association; 1998. 423-30.

60. Ayad H. Diabetic neuropathy: classification, clinical manifestations, diagnosis and management. Baba S et al, eds. Diabetes Mellitus in Asia. Amsterdam: Excerpta Medica; 1977. 222-4.

61. Thomas PK. Classification, differential diagnosis, and staging of diabetic peripheral neuropathy. Diabetes. 1997 Sep. 46 Suppl 2:S54-7. [QxMD MEDLINE Link].

62. All About Diabetes. Date Accessed: October 30, 2008. American Diabetes Association. [Full Text].

63. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: A report of the World Health Organization and International Diabetes Federation. Geneva, Switzerland: WHO Press; 2006.

64. Abbott CA, Vileikyte L, Williamson S, et al. Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration. Diabetes Care. 1998 Jul. 21(7):1071-5. [QxMD MEDLINE Link].

65. Llewelyn JG, Tomlinson DR, Thomas PK. Dyck PJ and Thomas PK. Diabetic Neuropathies in Peripheral Neuropathy. Philadelphia: Elsevier Saunders; 2005. 1951-91.

66. Lozeron P, Nahum L, Lacroix C, Ropert A, Guglielmi JM, Said G. Symptomatic diabetic and non-diabetic neuropathies in a series of 100 diabetic patients. J Neurol. 2002 May. 249(5):569-75. [QxMD MEDLINE Link].

67. Waldman SD. Diabetic neuropathy: diagnosis and treatment for the pain management specialist. Curr Rev Pain. 2000. 4(5):383-7. [QxMD MEDLINE Link].

68. Davidson MB. Diabetes Mellitus: Diagnosis and Treatment. 4th Ed. 1998. 297-307.

69. Vinik AI. New Methods to Assess Diabetic Neuropathy for Clinical Research.60th Scientific Sessions of the American Diabetes Association. American Diabetes Association; 2000.

70. Busko M. Common Tests May Miss Pediatric Diabetic Neuropathy. Medscape Medical News. Apr 11 2014. [Full Text].

71. Hirschfeld G, von Glischinski M, Blankenburg M, et al. Screening for peripheral neuropathies in children with diabetes: a systematic review. Pediatrics. 2014 Apr 7. [QxMD MEDLINE Link].

72. Walter-Holiner I, Barbarini DS, Lutschg J, et al. High Prevalence and Incidence of Diabetic Peripheral Neuropathy in Children and Adolescents With Type 1 Diabetes Mellitus: Results From a Five-Year Prospective Cohort Study. Pediatr Neurol. 2017 Dec 13. [QxMD MEDLINE Link].

73. Tkac I, Bril V. Glycemic control is related to the electrophysiologic severity of diabetic peripheral sensorimotor polyneuropathy. Diabetes Care. 1998 Oct. 21(10):1749-52. [QxMD MEDLINE Link].

74. Bril V. Electrophysiologic testing. Gries FA, Cameron NE, Low PA, Ziegler D. Textbook of Diabetic Neuropathy. Stuttgart, Germany: Thieme Medical Publishers; 2003. 177-84.

75. Huang CC, Chen TW, Weng MC, Lee CL, Tseng HC, Huang MH. Effect of glycemic control on electrophysiologic changes of diabetic neuropathy in type 2 diabetic patients. Kaohsiung J Med Sci. 2005 Jan. 21(1):15-21. [QxMD MEDLINE Link].

76. Smith AG, Russell J, Feldman EL, et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care. 2006 Jun. 29(6):1294-9. [QxMD MEDLINE Link].

77. Apfel SC. Neurotrophic factors in the therapy of diabetic neuropathy. Am J Med. 1999 Aug 30. 107(2B):34S-42S. [QxMD MEDLINE Link].

78. Apfel SC. Diabetic Polyneuropathy. Diabetes and Endocrinology Clinical Management. 1999.

79. Argoff CE, Backonja MM, Belgrade MJ, Bennett GJ, Clark MR, Cole BE, et al. Consensus guidelines: treatment planning and options. Diabetic peripheral neuropathic pain. Mayo Clin Proc. 2006 Apr. 81(4 Suppl):S12-25. [QxMD MEDLINE Link].

80. Boulton A. Current and Emerging Treatments for Diabetic Neuropathies. Diabetes Reviews. 7:379-86.

81. Slovenkai MP. Foot problems in diabetes. Med Clin North Am. 1998 Jul. 82(4):949-71. [QxMD MEDLINE Link].

82. O'Brien SP, Schwedler M, Kerstein MD. Peripheral neuropathies in diabetes. Surg Clin North Am. 1998 Jun. 78(3):393-408. [QxMD MEDLINE Link].

83. Martin CL, Albers J, Herman WH, et al. Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care. 2006 Feb. 29(2):340-4. [QxMD MEDLINE Link].

84. Sumner CJ, Sheth S, Griffin JW, et al. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology. 2003 Jan 14. 60(1):108-11. [QxMD MEDLINE Link].

85. Callaghan BC, Little AA, Feldman EL, Hughes RA. Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev. 2012 Jun 13. 6:CD007543. [QxMD MEDLINE Link].

86. Moore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2011 Mar 16. CD007938. [QxMD MEDLINE Link].

87. Ziegler D. Treatment of diabetic neuropathy and neuropathic pain: how far have we come?. Diabetes Care. 2008 Feb. 31 Suppl 2:S255-61. [QxMD MEDLINE Link].

88. Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy or chronic pain. Cochrane Database Syst Rev. 2009. (4):CD007115. [QxMD MEDLINE Link].

89. Chou R, Carson S, Chan BK. Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials. J Gen Intern Med. 2009 Feb. 24(2):178-88. [QxMD MEDLINE Link].

90. Hayee MA, Mohammad QD, Haque A. Diabetic neuropathy and zinc therapy. Bangladesh Med Res Counc Bull. 2005 Aug. 31(2):62-7. [QxMD MEDLINE Link].

91. Kawai T, Takei I, Tokui M, Funae O, Miyamoto K, Tabata M, et al. Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(varepsilon)-carboxymethyl lysine. J Diabetes Complications. 2009 Aug 26. [QxMD MEDLINE Link].

92. Schemmel KE, Padiyara RS, D'Souza JJ. Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. J Diabetes Complications. 2009 Sep 10. [QxMD MEDLINE Link].

93. Hotta N, Akanuma Y, Kawamori R, Matsuoka K, Oka Y, Shichiri M, et al. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care. 2006 Jul. 29(7):1538-44. [QxMD MEDLINE Link].

94. Ando H, Takamura T, Nagai Y, Kaneko S,. Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy. J Diabetes Complications. 2006 Nov-Dec. 20(6):367-70. [QxMD MEDLINE Link].

95. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med. 2005 Jan 27. 352(4):341-50. [QxMD MEDLINE Link].

96. Petersen EA, Stauss TG, Scowcroft JA, et al. Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial. JAMA Neurol. 2021 Jun 1. 78 (6):687-98. [QxMD MEDLINE Link]. [Full Text].

97. Daousi C, Benbow SJ, MacFarlane IA. Electrical spinal cord stimulation in the long-term treatment of chronic painful diabetic neuropathy. Diabet Med. 2005 Apr. 22(4):393-8. [QxMD MEDLINE Link].

98. Ahn AC, Bennani T, Freeman R, Hamdy O, Kaptchuk TJ. Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial. Acupunct Med. 2007 Jun. 25(1-2):11-7. [QxMD MEDLINE Link].

99. Miller RD. Anesthesia. 5th ed. New York: Churchill Livingstone; 2000.

100. Ferreira MC, Carvalho VF, Kamamoto F, Tuma P Jr, Paggiaro AO. Negative pressure therapy (vacuum) for wound bed preparation among diabetic patients: case series. Sao Paulo Med J. 2009. 127(3):166-70. [QxMD MEDLINE Link].

101. Crouch J. Charcot's joint and bilateral foot neuropathy. Adv Nurse Pract. 2005 Mar. 13(3):18. [QxMD MEDLINE Link].

102. Pfeiffer MA, Schumer M. Painful or insensitive lower extremity. Therapy for Diabetes Mellitus. American Diabetes Association; 1998.

103. Johnson CE, Takemoto JK. A Review of Beneficial Low-Intensity Exercises in Diabetic Peripheral Neuropathy Patients. J Pharm Pharm Sci. 2019. 22 (1):22-7. [QxMD MEDLINE Link]. [Full Text].

104. [Guideline] Colberg SR, Sigal RJ, Yardley JE, et al. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care. 2016 Nov. 39 (11):2065-79. [QxMD MEDLINE Link]. [Full Text].

105. Somers DL, Somers MF. Treatment of neuropathic pain in a patient with diabetic neuropathy using transcutaneous electrical nerve stimulation applied to the skin of the lumbar region. Phys Ther. 1999 Aug. 79(8):767-75. [QxMD MEDLINE Link].

106. [Guideline] Bril V, England J, Franklin GM, et al. Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. Prepublished online April 11, 2011. [Full Text].

107. Tavakoli M, Kallinikos P, Iqbal A, et al. Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabet Med. 2011 Oct. 28(10):1261-7. [QxMD MEDLINE Link]. [Full Text].

108. Possidente CJ, Tandan R. A survey of treatment practices in diabetic peripheral neuropathy. Prim Care Diabetes. 2009 Nov. 3(4):253-7. [QxMD MEDLINE Link].

109. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA. 1998 Dec 2. 280(21):1831-6. [QxMD MEDLINE Link].

110. Bennett GJ, Dworkin RH, Nicholson B. Anticonvulsant Therapy in the Treatment of Neuropathic Pain. Neurology Treatment Update. 2000.

111. Bomholt SF, Mikkelsen JD, Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology. 2005 Feb. 48(2):252-63. [QxMD MEDLINE Link].

112. Ziegler D, Movsesyan L, Mankovsky B, Gurieva I, Abylaiuly Z, Strokov I. Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients. Diabetes Care. 2009 Aug. 32(8):1479-84. [QxMD MEDLINE Link]. [Full Text].

113. Lesser H, Sharma U, LaMoreaux L, Poole RM. Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology. 2004 Dec 14. 63(11):2104-10. [QxMD MEDLINE Link].

114. Huffman CL, Goldenberg JN, Weintraub J, et al. Efficacy and Safety of Once-Daily Controlled-Release Pregabalin for the Treatment of Patients With Postherpetic Neuralgia: A Double-Blind, Enriched Enrollment Randomized Withdrawal, Placebo-Controlled Trial. Clin J Pain. 2017 Jul. 33 (7):569-78. [QxMD MEDLINE Link].

115. Bril V, England J, Franklin GM, Backonja M, Cohen J, Del Toro D, et al. Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2011 Apr 11. [QxMD MEDLINE Link].

116. Wiffen PJ, Derry S, Moore RA, McQuay HJ. Carbamazepine for acute and chronic pain in adults. Cochrane Database Syst Rev. 2011 Jan 19. CD005451. [QxMD MEDLINE Link].

117. FDA Requires Boxed Warning and Risk Mitigation Strategy for Metoclopramide-Containing Drugs. U.S. Food and Drug Administration. Available at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149533.htm. Accessed: May 16, 2000.

Dianna Quan, MD Professor of Neurology, Director of Electromyography Laboratory, University of Colorado School of Medicine

Dianna Quan, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Neurological Association

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: American Association of Neuromuscular and Electrodiagnostic Medicine; American Neuromuscular Foundation<br/>Serve(d) as a speaker or a member of a speakers bureau for: Alnylam<br/>Received research grant from: Alnylam; Pfizer; Ionis; Cytokinetics; Momenta/Janssen; Viela Bio; Avidity bioscience.

Helen C Lin, MD Assistant Professor of Neurology, Medical College of Wisconsin

Helen C Lin, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine

Disclosure: Nothing to disclose.

Romesh Khardori, MD, PhD, FACP (Retired) Professor, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Neil A Busis, MD Chief, Division of Neurology, Department of Medicine, Head, Clinical Neurophysiology Laboratory, University of Pittsburgh Medical Center-Shadyside

Neil A Busis, MD is a member of the following medical societies: American Academy of Neurology and American Association of Neuromuscular and Electrodiagnostic Medicine

Disclosure: Nothing to disclose.

Milind J Kothari, DO Professor and Vice-Chair, Department of Neurology, Pennsylvania State University College of Medicine; Consulting Staff, Department of Neurology, Penn State Milton S Hershey Medical Center

Milind J Kothari, DO is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Neurological Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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