Focal Muscular Atrophies Medication

Updated: Oct 21, 2015
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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Medication

Medication Summary

The goal of pharmacotherapy is to reduce morbidity.

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Blood products

Class Summary

These are useful in minimizing the effects of autoimmune reactions.

Intravenous immunoglobulin (IVIg)

Following features may be relevant to its efficacy: neutralization of circulating antibodies through anti-idiotypic antibodies; down-regulation of pro-inflammatory cytokines, including IFN-gamma; blockade of Fc receptors on macrophages; suppression of inducer T and B cells and augmentation of suppressor T cells; blockade of complement cascade.

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Glucocorticoids

Class Summary

These agents modify the body's immune response to diverse stimuli. Likely mechanisms of action are inhibition of synthesis/secretion of TNF-alpha, IL-6, IL-2, and IFN-gamma, and modulation of serum and leukocyte-bound levels of cell adhesion molecules.

Prednisone (Sterapred)

Useful in treatment of inflammatory and immune reactions. By reversing increased capillary permeability and suppressing PMN activity, may decrease inflammation. Dosage and length of treatment vary depending on specific diagnosis.

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