Lambert-Eaton Myasthenic Syndrome (LEMS) Questions & Answers

Updated: May 23, 2019
  • Author: David E Stickler, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Questions & Answers

Overview

What is Lambert-Eaton myasthenic syndrome (LEMS)?

What is the pathophysiology of Lambert-Eaton myasthenic syndrome (LEMS)?

What causes Lambert-Eaton myasthenic syndrome (LEMS)?

What causes Lambert-Eaton myasthenic syndrome (LEMS)?

What is the epidemiology of Lambert-Eaton myasthenic syndrome (LEMS) in the US?

What are the demographics of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the prognosis of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the relationship between small cell lung cancer (SCLC) and Lambert-Eaton myasthenic syndrome (LEMS)?

Presentation

What are the symptoms of Lambert-Eaton myasthenic syndrome (LEMS)?

How does muscle weakness in Lambert-Eaton myasthenic syndrome (LEMS) compare to that of myasthenia gravis (MG)?

What are other symptoms of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the relationship between cancer and Lambert-Eaton myasthenic syndrome (LEMS)?

What are the physical findings in Lambert-Eaton myasthenic syndrome (LEMS)?

DDX

What are the diagnostic considerations of Lambert-Eaton myasthenic syndrome (LEMS)?

What are the differential diagnoses for Lambert-Eaton Myasthenic Syndrome (LEMS)?

Workup

What are the approach considerations in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the role of voltage-gated calcium channel (VGCC) antibody testing in Lambert-Eaton myasthenic syndrome (LEMS)?

What is the role of ACh receptor antibody testing in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

How are imaging studies and bronchoscopy used in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

Which nerve stimulation studies are indicated in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

How is needle electromyography used in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

How is single-fiber electromyography used in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the role of edrophonium (Tensilon) testing in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?

Treatment

What are the treatment approach considerations in Lambert-Eaton myasthenic syndrome (LEMS)?

What is the initial management of Lambert-Eaton myasthenic syndrome (LEMS)?

Which medications should be avoided in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the approach to cancer workup and treatment in Lambert-Eaton myasthenic syndrome (LEMS)?

Which medications are used in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?

What is the role of plasma exchange and high-dose IVIg in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?

Which specialist consultations are indicated in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?

What long-term monitoring is indicated in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?

Medications

What is the drug treatment for Lambert-Eaton myasthenic syndrome (LEMS)?

Which medications in the drug class Immunosuppressants are used in the treatment of Lambert-Eaton Myasthenic Syndrome (LEMS)?

Which medications in the drug class Cholinergic Agonists are used in the treatment of Lambert-Eaton Myasthenic Syndrome (LEMS)?

Which medications in the drug class Potassium Channel Blockers are used in the treatment of Lambert-Eaton Myasthenic Syndrome (LEMS)?

Which medications in the drug class Blood products are used in the treatment of Lambert-Eaton Myasthenic Syndrome (LEMS)?