Limb-Girdle Muscular Dystrophy Questions & Answers

Updated: Aug 15, 2019
  • Author: Monica Saini, MBBS, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Questions & Answers

Overview

What is limb-girdle muscular dystrophy (LGMD)?

What are the signs and symptoms of limb-girdle muscular dystrophy (LGMD)?

How is limb-girdle muscular dystrophy (LGMD) diagnosed?

What is the approach to treatment of limb-girdle muscular dystrophy (LGMD)?

How was limb-girdle muscular dystrophy (LGMD) initially defined?

What was the alphanumeric classification of limb-girdle muscular dystrophy (LGMD)?

What is the 229th ENMC international workshop definition of limb-girdle muscular dystrophy (LGMD)?

Which conditions are no longer considered subtypes of limb-girdle muscular dystrophy (LGMD)?

How is limb-girdle muscular dystrophy (LGMD) currently classified?

What is the pathophysiology of limb-girdle muscular dystrophy (LGMD)

What is the prevalence of limb-girdle muscular dystrophy (LGMD)

What is the morbidity and mortality associated with limb-girdle muscular dystrophy (LGMD)

What are the racial predilections of limb-girdle muscular dystrophy (LGMD)

What are the sexual predilections of limb-girdle muscular dystrophy (LGMD)

At what age is limb-girdle muscular dystrophy (LGMD) typically diagnosed?

What is the prognosis of limb-girdle muscular dystrophy (LGMD)?

Presentation

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2B (LGMD2B)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2C-2F (LGMD2C-2F)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2G (LGMD2G)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2H (LGMD2H)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2I (LGMD2I)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2J (LGMD2J)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2K (LGMD2K)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2L (LGMD2L)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2M (LGMD2M)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2N (LGMD2N)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2O (LGMD2O)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2P (LGMD2P)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2Q (LGMD2Q)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2R (LGMD2R)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2S (LGMD2S)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2T (LGMD2T)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2U (LGMD2U)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2V (LGMD2V)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2W (LGMD2W)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2X (LGMD2X)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2Y (LGMD2Y)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2Z (LGMD2Z)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy R22 (LGMDR22)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy R23 (LGMDR23)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy R24 (LGMDR24)?

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1A (LGMD1A)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1B (LGMD1B)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1C (LGMD1C)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1D (LGMD1D)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1E (LGMD1E)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1F (LGMD1F)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1G (LGMD1G)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1H (LGMD1H)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1I (LGMD1I)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy D5 (LGMDD5)

Which clinical history findings are characteristic of limb-girdle muscular dystrophy (LGMD)?

Which clinical history findings are characteristic of autosomal-recessive limb-girdle muscular dystrophy 2A (LGMD2A)

Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy (LGMD)?

Which clinical history findings help to differentiate among limb-girdle muscular dystrophy (LGMD) types?

Which clinical history findings are characteristic of myofibrillar myopathies?

What causes limb-girdle muscular dystrophy (LGMD)?

What causes myofibrillar myopathies?

DDX

What are the differential diagnoses for Limb-Girdle Muscular Dystrophy?

Workup

What is the role of lab tests in the workup of limb-girdle muscular dystrophy (LGMD)?

What is the role of MRI in the workup of limb-girdle muscular dystrophy (LGMD)?

What are the roles of EMG and NCS in the workup of limb-girdle muscular dystrophy (LGMD)?

What is the role of EEG in the workup of limb-girdle muscular dystrophy (LGMD)?

What is the role of muscle biopsy in the workup of limb-girdle muscular dystrophy (LGMD)?

Which histologic findings are characteristic of limb-girdle muscular dystrophy (LGMD)?

Treatment

How is limb-girdle muscular dystrophy (LGMD) treated?

How are cardiac diseases treated in limb-girdle muscular dystrophy (LGMD)?

How is respiratory failure treated in limb-girdle muscular dystrophy (LGMD)?

How is dysphagia treated in limb-girdle muscular dystrophy (LGMD)?

How are the skeletomuscular manifestations of limb-girdle muscular dystrophy (LGMD) treated?

What is the role of surgery in the treatment of limb-girdle muscular dystrophy (LGMD)?

Which specialist consultations are beneficial to patients with limb-girdle muscular dystrophy (LGMD)?

Which activity modifications are used in the treatment of limb-girdle muscular dystrophy (LGMD)?

Guidelines

What are the AAN and AANEM guidelines for the diagnosis and treatment of limb-girdle muscular dystrophy (LGMD)?

Follow-up

What is included in the long-term monitoring of limb-girdle muscular dystrophy (LGMD)?

When is inpatient care indicated for the treatment of limb-girdle muscular dystrophy (LGMD)?

What are the possible complications of limb-girdle muscular dystrophy (LGMD)?

What is the prognosis of limb-girdle muscular dystrophy (LGMD)?

What is included in patient education about limb-girdle muscular dystrophy (LGMD)?