Stiff Person Syndrome Questions & Answers

Updated: Jun 14, 2018
  • Author: Nancy Theresa Rodgers-Neame, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Questions & Answers

Overview

What is stiff person syndrome?

What is the pathophysiology of stiff person syndrome?

What is the prevalence of stiff person syndrome?

What are the complications of stiff person syndrome?

Presentation

Which clinical history findings are characteristic of stiff person syndrome?

What is stiff baby syndrome?

Which disorders are associated with stiff person syndrome?

Which physical findings are characteristic of stiff person syndrome?

What are the stages of stiff person syndrome?

What are the variants of stiff person syndrome?

What causes stiff person syndrome?

DDX

Which conditions should be included in the differential diagnoses of stiff person syndrome?

What are the differential diagnoses for Stiff Person Syndrome?

Workup

Which lab studies are performed in the workup of stiff person syndrome?

What is the role of imaging studies in the workup of stiff person syndrome?

What is the role of EMG and EEG in workup of stiff person syndrome?

What is the role of lumbar puncture in the workup of stiff person syndrome?

Treatment

What is the initial treatment for stiff person syndrome?

What is the role of intrathecal baclofen therapy in the treatment of stiff person syndrome?

What is the role of plasmapheresis (plasma exchange) in the treatment of stiff person syndrome?

What is the role of IV immunoglobulin in the treatment of stiff person syndrome?

What is the role of physical therapy and occupational therapy in the treatment of stiff person syndrome?

Which specialist consultations may be beneficial to patients with stiff person syndrome?

Which activity modifications are used in the treatment of stiff person syndrome?

Medications

What is the goal of drug treatment for stiff person syndrome?

Which medications in the drug class Skeletal muscle relaxants are used in the treatment of Stiff Person Syndrome?

Which medications in the drug class Immune modulators are used in the treatment of Stiff Person Syndrome?

Which medications in the drug class Benzodiazepines are used in the treatment of Stiff Person Syndrome?

Follow-up

What is included in the long-term care for stiff person syndrome?

Which medications are used in the treatment of stiff person syndrome?

How is pain managed in stiff person syndrome?

Which novel medications have been used in the treatment of stiff person syndrome?

What are indications for patient transfer for treatment of stiff person syndrome?

What are the complications of stiff person syndrome?

What is the prognosis of stiff person syndrome?

Where can patient education resources about stiff person syndrome be found?