Inclusion Body Myositis Questions & Answers

Updated: Jun 08, 2018
  • Author: Michael P Collins, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
  • Print
Questions & Answers

Overview

What is sporadic inclusion body myositis (s-IBM)?

What is the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the role of inflammation in the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the role of humoral immunity to the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the role of degenerative processes in the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the role of rimmed vacuoles in the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the role of mitochondrial abnormalities in the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What are the possible links between degenerative and inflammatory changes in the pathophysiology of sporadic inclusion body myositis (s-IBM)?

What is the prevalence of sporadic inclusion body myositis (s-IBM) in the US?

What is the global prevalence of sporadic inclusion body myositis (s-IBM)?

What is the mortality and morbidity associated with sporadic inclusion body myositis (s-IBM)?

What are the racial predilections for sporadic inclusion body myositis (s-IBM)?

What are the sexual predilections for sporadic inclusion body myositis (s-IBM)?

Which age groups have the highest prevalence of sporadic inclusion body myositis (s-IBM)?

Presentation

Which clinical history findings are characteristic of sporadic inclusion body myositis (s-IBM)?

Which physical findings are characteristic of sporadic inclusion body myositis (s-IBM)?

What causes sporadic inclusion body myositis (s-IBM)?

DDX

Which conditions are included in the differential diagnoses of sporadic inclusion body myositis (s-IBM)?

Which conditions are associated with sporadic inclusion body myositis (s-IBM)?

What are the differential diagnoses for Inclusion Body Myositis?

Workup

What is the role of lab testing in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of imaging studies in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of quantitative sensory testing in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of nerve conduction studies in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of electrodiagnostic studies in the workup of sporadic inclusion body myositis (s-IBM)?

Which motor unit action potentials (MUAPs) findings are characteristic of sporadic inclusion body myositis (s-IBM)?

What is the role of respiratory testing in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of muscle biopsy in the workup of sporadic inclusion body myositis (s-IBM)?

Which histologic findings are characteristic of sporadic inclusion body myositis (s-IBM)?

What is the role of Immunohistochemical staining in the workup of sporadic inclusion body myositis (s-IBM)?

What is the role of electron microscopy in the workup of sporadic inclusion body myositis (s-IBM)?

What are the proposed morphologic criteria for diagnosis of sporadic inclusion body myositis (s-IBM)?

Treatment

How is sporadic inclusion body myositis (s-IBM) treated?

What is the efficacy of medial treatment of sporadic inclusion body myositis (s-IBM)?

What are other medical studies done for the treatment of sporadic inclusion body myositis (s-IBM)?

What is the role of surgery in the treatment of sporadic inclusion body myositis (s-IBM)?

Which specialist consultations are beneficial to patients with sporadic inclusion body myositis (s-IBM)?

Which dietary modifications are used in the treatment of sporadic inclusion body myositis (s-IBM)?

Which activity modifications are used in the treatment of sporadic inclusion body myositis (s-IBM)?

Medications

What is the role of medications in the treatment of sporadic inclusion body myositis (s-IBM)?

Follow-up

When is follow-up care needed for sporadic inclusion body myositis (s-IBM)?

What are the possible complications of sporadic inclusion body myositis (s-IBM)?

What is the prognosis of sporadic inclusion body myositis (s-IBM)?

What is included in patient education about sporadic inclusion body myositis (s-IBM)?