Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies Questions & Answers

Updated: May 22, 2018
  • Author: Timothy C Parsons, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Questions & Answers

Overview

When was Charcot-Marie-Tooth (CMT) disease first identified?

How has the classification of Charcot-Marie-Tooth (CMT) disease evolved?

What is the pathophysiology of Charcot-Marie-Tooth type 1A (CMT1A)?

What is the pathophysiology of Charcot-Marie-Tooth type 1B (CMT1B)?

What is the pathophysiology of Charcot-Marie-Tooth type X (CMTX)?

What is the pathophysiology of Charcot-Marie-Tooth type 2 (CMT2)?

What is the pathophysiology of Charcot-Marie-Tooth type 4 (CMT4)?

What is the global prevalence of Charcot-Marie-Tooth (CMT) disease?

What is the morbidity of Charcot-Marie-Tooth (CMT) disease?

What are the racial predilections of Charcot-Marie-Tooth (CMT) disease?

What are the sexual predilections of Charcot-Marie-Tooth (CMT) disease?

In which age groups is the onset of Charcot-Marie-Tooth (CMT) disease most common?

Presentation

Which clinical history findings are characteristic of Charcot-Marie-Tooth (CMT) disease?

What are the signs and symptoms of Charcot-Marie-Tooth (CMT) disease?

Which clinical history findings are characteristic of Charcot-Marie-Tooth type 1B (CMT1B)?

Which clinical history findings are characteristic of Charcot-Marie-Tooth type 2 (CMT2)?

Which clinical history findings are characteristic of Dejerine-Sottas disease?

Which clinical history findings are characteristic of Charcot-Marie-Tooth type X (CMTX)?

Which clinical history findings are characteristic of Charcot-Marie-Tooth type 4 (CMT4)?

Which clinical history findings are characteristic of atypical Charcot-Marie-Tooth (CMT) disease?

Which nerve findings are characteristic of Charcot-Marie-Tooth (CMT) disease?

Which motor signs are characteristic of Charcot-Marie-Tooth (CMT) disease?

Which sensory findings are characteristic of Charcot-Marie-Tooth (CMT) disease?

Which foot deformities are characteristic of Charcot-Marie-Tooth (CMT) disease?

Which physical findings are characteristic of specific Charcot-Marie-Tooth (CMT) disease subtypes?

What causes Charcot-Marie-Tooth (CMT) disease?

DDX

Which conditions are included in the differential diagnoses of Charcot-Marie-Tooth (CMT) disease?

Workup

What is the role of lab testing in the workup of Charcot-Marie-Tooth (CMT) disease?

What is the role of imaging studies in the workup of Charcot-Marie-Tooth (CMT) disease?

What is the role of CSF analysis in the diagnosis of Charcot-Marie-Tooth (CMT) disease?

What is the role of electrodiagnostic studies in the evaluation of Charcot-Marie-Tooth (CMT) disease?

Which histologic findings are characteristic of Charcot-Marie-Tooth type 1 (CMT1)?

Which histologic findings are characteristic of Charcot-Marie-Tooth type 1A (CMT1A)?

Which histologic findings are characteristic of Charcot-Marie-Tooth type 2 (CMT2)?

Which histologic findings are characteristic of Charcot-Marie-Tooth type X (CMTX)?

Treatment

How are the orthopedic complications of Charcot-Marie-Tooth (CMT) disease treated?

How is Charcot-Marie-Tooth (CMT) disease treated?

What is the role of surgery in the treatment of Charcot-Marie-Tooth (CMT) disease?

Which specialist consultations are beneficial to patients Charcot-Marie-Tooth (CMT) disease?

Which dietary modifications are used in the treatment of Charcot-Marie-Tooth (CMT) disease?

Which activity modifications are used in the treatment of Charcot-Marie-Tooth (CMT) disease?

Medications

What is the role of drug treatment for Charcot-Marie-Tooth (CMT) disease?

Which medications in the drug class Anticonvulsants are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Which medications in the drug class Serotonin reuptake inhibitors are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Which medications in the drug class Antidepressants are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Which medications in the drug class Nonsteroidal anti-inflammatory drugs (NSAIDS) are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Follow-up

How is Charcot-Marie-Tooth (CMT) disease prevented?

What are the possible complications of Charcot-Marie-Tooth (CMT) disease?

What is the prognosis of Charcot-Marie-Tooth (CMT) disease?

Which organization provides patient resources for Charcot-Marie-Tooth (CMT) disease?