Autonomic Neuropathy Differential Diagnoses

1. Delahaye N, Rouzet F, Sarda L, et al. Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy. Medicine (Baltimore). 2006. 85(4):229-238. [QxMD MEDLINE Link].

2. Davidson GL, Murphy SM, Polke JM, Laura M, Salih MA, Muntoni F, et al. Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort. J Neurol. 2012 Feb 1. [QxMD MEDLINE Link].

3. Bejaoui K, Wu C, Scheffler MD, et al. SPTLC1 is mutated in hereditary sensory neuropathy, type 1. Nat Genet. 2001 Mar. 27(3):261-2. [QxMD MEDLINE Link].

4. Low PA, Vernino S, Suarez G. Autonomic dysfunction in peripheral nerve disease. Muscle Nerve. 2003 Jun. 27(6):646-61. [QxMD MEDLINE Link].

5. Ohto T, Iwasaki N, Fujiwara J, et al. The evaluation of autonomic nervous function in a patient with hereditary sensory and autonomic neuropathy type IV with novel mutations of the TRKA gene. Neuropediatrics. 2004 Oct. 35(5):274-8. [QxMD MEDLINE Link].

6. Einarsdottir E, Carlsson A, Minde J, et al. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Hum Mol Genet. 2004 Apr 15. 13(8):799-805. [QxMD MEDLINE Link].

7. Low PA. Clinical autonomic disorders: evaluation and management. 2nd ed. New York: Lippincott Raven; 1997.

8. Low PA, Dyck PJ, Lambert EH, et al. Acute panautonomic neuropathy. Ann Neurol. 1983 Apr. 13(4):412-7. [QxMD MEDLINE Link].

9. Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21. 343(12):847-55. [QxMD MEDLINE Link].

10. Stewart JD, Low PA, Fealey RD. Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes. Muscle Nerve. 1992 Jun. 15(6):661-5. [QxMD MEDLINE Link].

11. Emond D, Lebel M. Orthostatic hypotension and Holmes-Adie syndrome. Usefulness of the Valsalva ratio in the evaluation of baroreceptor dysfunction. J Hum Hypertens. 2002 Sep. 16(9):661-2. [QxMD MEDLINE Link].

12. Nolano M, Provitera V, Perretti A, Stancanelli A, Saltalamacchia AM, Donadio V, et al. Ross syndrome: a rare or a misknown disorder of thermoregulation? A skin innervation study on 12 subjects. Brain. 2006 Aug. 129:2119-31. [QxMD MEDLINE Link].

13. Low PA, Fealey RD, Sheps SG, Su WP, Trautmann JC, Kuntz NL. Chronic idiopathic anhidrosis. Ann Neurol. 1985 Sep. 18(3):344-8. [QxMD MEDLINE Link].

14. Benson MD, Kincaid JC. The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve. 2007 Oct. 36(4):411-23. [QxMD MEDLINE Link].

15. Kyle RA, Greipp PR. Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc. 1983 Oct. 58(10):665-83. [QxMD MEDLINE Link].

16. Low PA, Novak V, Spies JM, et al. Cerebrovascular regulation in the postural orthostatic tachycardia syndrome (POTS). Am J Med Sci. 1999 Feb. 317(2):124-33. [QxMD MEDLINE Link].

17. Novak V, Novak P, Opfer-Gehrking TL, et al. Clinical and laboratory indices that enhance the diagnosis of postural tachycardia syndrome. Mayo Clin Proc. 1998 Dec. 73(12):1141-50. [QxMD MEDLINE Link].

18. Zochodne DW. Diabetic neuropathies: features and mechanisms. Brain Pathol. 1999 Apr. 9(2):369-91. [QxMD MEDLINE Link].

19. Vinik AI, Freeman R, Erbas T. Diabetic autonomic neuropathy. Semin Neurol. 2003 Dec. 23(4):365-72. [QxMD MEDLINE Link].

20. Clements RS Jr, Flint MA. Coping with autonomic neuropathy. J Diabet Complications. 1988 Jul-Sep. 2(3):130-2. [QxMD MEDLINE Link].

21. Supriya Simon A, Dinesh Roy D, Jayapal V, Vijayakumar T. Somatic DNA damages in cardiovascular autonomic neuropathy. Indian J Clin Biochem. 2011 Jan. 26(1):50-6. [QxMD MEDLINE Link]. [Full Text].

22. Semra YK, Wang M, Peat NJ, et al. Selective susceptibility of different populations of sympathetic neurons to diabetic neuropathy in vivo is reflected by increased vulnerability to oxidative stress in vitro. Neurosci Lett. 2006 Oct 30. 407(3):199-204. [QxMD MEDLINE Link].

23. Zochodne DW. The autonomic nervous system in peripheral neuropathies. Handbook of Clinical Neurology. 2000. 75(31):681-712.

24. Maheshwari A, Thomas A, Thuluvath PJ. Patients with autonomic neuropathy are more likely to develop hepatic encephalopathy. Dig Dis Sci. 2004 Oct. 49(10):1584-8. [QxMD MEDLINE Link].

25. Beitzke M, Pfister P, Fortin J, Skrabal F. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci. 2002 Apr 18. 97(1):45-54. [QxMD MEDLINE Link].

26. Koike H, Sobue G. Alcoholic neuropathy. Curr Opin Neurol. 2006 Oct. 19(5):481-6. [QxMD MEDLINE Link].

27. Duray PH. Histopathology of clinical phases of human Lyme disease. Rheum Dis Clin North Am. 1989 Nov. 15(4):691-710. [QxMD MEDLINE Link].

28. Glück T, Degenhardt E, Schölmerich J, Lang B, Grossmann J, Straub RH. Autonomic neuropathy in patients with HIV: course, impact of disease stage, and medication. Clin Auton Res. 2000 Feb. 10(1):17-22. [QxMD MEDLINE Link].

29. Cohen JA, Laudenslager M. Autonomic nervous system involvement in patients with human immunodeficiency virus infection. Neurology. 1989 Aug. 39(8):1111-2. [QxMD MEDLINE Link].

30. Fernandez A, Hontebeyrie M, Said G. Autonomic neuropathy and immunological abnormalities in Chagas' disease. Clin Auton Res. 1992 Dec. 2(6):409-12. [QxMD MEDLINE Link].

31. Pentreath VW. Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 19 May 1994. Trypanosomiasis and the nervous system. Pathology and immunology. Trans R Soc Trop Med Hyg. 1995 Jan-Feb. 89(1):9-15. [QxMD MEDLINE Link].

32. Pickett JB 3rd. AAEE case report #16: Botulism. Muscle Nerve. 1988 Dec. 11(12):1201-5. [QxMD MEDLINE Link].

33. Idiaquez J. Autonomic dysfunction in diphtheritic neuropathy. J Neurol Neurosurg Psychiatry. 1992 Feb. 55(2):159-61. [QxMD MEDLINE Link].

34. Scollard DM. The biology of nerve injury in leprosy. Lepr Rev. 2008 Sep. 79(3):242-53. [QxMD MEDLINE Link].

35. Kyriakidis MK, Noutsis CG, Robinson-Kyriakidis CA, Venetsianos PJ, Vyssoulis GP, Toutouzas PC, et al. Autonomic neuropathy in leprosy. Int J Lepr Other Mycobact Dis. 1983 Sep. 51(3):331-5. [QxMD MEDLINE Link].

36. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr. 76(4):579-81. [QxMD MEDLINE Link].

37. Tursi A, Giorgetti GM, Iani C. Peripheral Neurological Disturbances, Autonomic Dysfunction, and Antineuronal Antibodies in Adult Celiac Disease Before and After a Gluten-Free Diet. Dig Dis Sci. 2006 Sep 12; [Epub ahead of print]. [QxMD MEDLINE Link].

38. Gemignani F, Marbini A, Pavesi G, Di Vittorio S, Manganelli P, Cenacchi G, et al. Peripheral neuropathy associated with primary Sjögren's syndrome. J Neurol Neurosurg Psychiatry. 1994 Aug. 57(8):983-6. [QxMD MEDLINE Link].

39. Zochodne DW. Autonomic involvement in Guillain-Barré syndrome: a review. Muscle Nerve. 1994 Oct. 17(10):1145-55. [QxMD MEDLINE Link].

40. Panegyres PK, Mastaglia FL. Guillain-Barre syndrome with involvement of the central and autonomic nervous systems. Med J Aust. 1989 Jun 5. 150(11):655-9. [QxMD MEDLINE Link].

41. O'Suilleabhain P, Low PA, Lennon VA. Autonomic dysfunction in the Lambert-Eaton myasthenic syndrome: serologic and clinical correlates. Neurology. 1998 Jan. 50(1):88-93. [QxMD MEDLINE Link].

42. Sillevis Smitt P, Grefkens J, de Leeuw B, et al. Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy. J Neurol. 2002 Jun. 249(6):745-53. [QxMD MEDLINE Link].

43. Zenone T. [Autoimmunity and cancer: paraneoplastic neurological syndromes associated with small cell cancer]. Bull Cancer. 1992. 79(9):837-53. [QxMD MEDLINE Link].

44. Yu Z, Kryzer TJ, Griesmann GE, et al. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol. 2001 Feb. 49(2):146-54. [QxMD MEDLINE Link].

45. Straub RH, Antoniou E, Zeuner M, et al. Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis. J Neuroimmunol. 1997 Dec. 80(1-2):149-57. [QxMD MEDLINE Link].

46. Rose KM, Eigenbrodt ML, Biga RL, Couper DJ, Light KC, Sharrett AR, et al. Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study. Circulation. 2006 Aug 15. 114(7):630-6. [QxMD MEDLINE Link].

47. Suarez GA, Opfer-Gehrking TL, Offord KP, et al. The Autonomic Symptom Profile: a new instrument to assess autonomic symptoms. Neurology. 1999 Feb. 52(3):523-8. [QxMD MEDLINE Link].

48. Serhiyenko VA, Serhiyenko AA. Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. World J Diabetes. 2018 Jan 15. 9 (1):1-24. [QxMD MEDLINE Link].

49. Watkins PJ. Diabetic diarrhea, gastroparesis, and gustatory sweating. Dyck PJ, Thomas PK, Asbury AK, et al, eds. Diabetic Neuropathy. Philadelphia: WB Saunders Co; 1987. 199-200.

50. Bharucha AE, Camilleri M, Low PA, Zinsmeister AR. Autonomic dysfunction in gastrointestinal motility disorders. Gut. 1993 Mar. 34(3):397-401. [QxMD MEDLINE Link].

51. Törnblom H. Treatment of gastrointestinal autonomic neuropathy. Diabetologia. 2016 Mar. 59 (3):409-13. [QxMD MEDLINE Link].

52. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, et al. Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology. 2009 Jan 13. 72(2):177-84. [QxMD MEDLINE Link].

53. Foss CH, Vestbo E, Frøland A, Gjessing HJ, Mogensen CE, Damsgaard EM. Autonomic neuropathy in nondiabetic offspring of type 2 diabetic subjects is associated with urinary albumin excretion rate and 24-h ambulatory blood pressure: the Fredericia Study. Diabetes. 2001 Mar. 50(3):630-6. [QxMD MEDLINE Link].

54. Fealey RD. Thermoregulatory sweat test. Low PA, ed. Clinical Autonomic Disorders: Evaluation and Management. 2nd ed. Philadelphia: Lippincott-Raven; 1997. 245-57.

55. Yarnitsky D, Sprecher E. Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci. 1994 Aug. 125(1):39-45. [QxMD MEDLINE Link].

56. Davies DR, Smith SE. Pupil abnormality in amyloidosis with autonomic neuropathy. J Neurol Neurosurg Psychiatry. 1999 Dec. 67(6):819-22. [QxMD MEDLINE Link].

57. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10. 70(24):2299-304. [QxMD MEDLINE Link].

58. Madersbacher HG. Neurogenic bladder dysfunction. Curr Opin Urol. 1999 Jul. 9(4):303-7. [QxMD MEDLINE Link].

59. Ascaso JF, Herreros B, Sanchiz V, et al. Oesophageal motility disorders in type 1 diabetes mellitus and their relation to cardiovascular autonomic neuropathy. Neurogastroenterol Motil. 2006. 18(9):813-822. [QxMD MEDLINE Link].

60. Bissinger A, Grycewicz T, Grabowicz W, Lubinski A. The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. Arch Med Sci. 2011 Oct. 7(5):806-12. [QxMD MEDLINE Link]. [Full Text].

61. Pavy-Le Traon A, Fontaine S, Tap G, Guidolin B, Senard JM, Hanaire H. Cardiovascular autonomic neuropathy and other complications in type 1 diabetes. Clin Auton Res. 2010 Jun. 20(3):153-60. [QxMD MEDLINE Link].

62. Ohlsson B, Melander O, Thorsson O, et al. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis. Diabetologia. 2006 Sep. 49(9):2010-4. [QxMD MEDLINE Link].

63. Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain. 2008 Jul. 131:1912-25. [QxMD MEDLINE Link].

64. Singer W, Spies JM, McArthur J, et al. Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies. Neurology. 2004 Feb 24. 62(4):612-8. [QxMD MEDLINE Link].

65. Nolano M, Provitera V, Crisci C, et al. Quantification of myelinated endings and mechanoreceptors in human digital skin. Ann Neurol. 2003 Aug. 54(2):197-205. [QxMD MEDLINE Link].

66. Nolano M, Crisci C, Santoro L, et al. Absent innervation of skin and sweat glands in congenital insensitivity to pain with anhidrosis. Clin Neurophysiol. 2000 Sep. 111(9):1596-601. [QxMD MEDLINE Link].

67. Klein CM, Vernino S, Lennon VA, et al. The spectrum of autoimmune autonomic neuropathies. Ann Neurol. 2003 Jun. 53(6):752-8. [QxMD MEDLINE Link].

68. Low PA. Composite autonomic scoring scale for laboratory quantification of generalized autonomic failure. Mayo Clin Proc. 1993 Aug. 68(8):748-52. [QxMD MEDLINE Link].

69. Jordan J, Shannon JR, Black BK, et al. The pressor response to water drinking in humans : a sympathetic reflex?. Circulation. 2000 Feb 8. 101(5):504-9. [QxMD MEDLINE Link].

70. van Lieshout JJ, ten Harkel AD, Wieling W. Physical manoeuvres for combating orthostatic dizziness in autonomic failure. Lancet. 1992 Apr 11. 339(8798):897-8. [QxMD MEDLINE Link].

71. Thieben MJ, Sandroni P, Sletten DM, Benrud-Larson LM, Fealey RD, Vernino S, et al. Postural orthostatic tachycardia syndrome: the Mayo clinic experience. Mayo Clin Proc. 2007 Mar. 82(3):308-13. [QxMD MEDLINE Link].

72. Freeman R. Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008 Mar. 18 Suppl 1:14-8. [QxMD MEDLINE Link].

73. Low PA. Autonomic neuropathies. Curr Opin Neurol. 1998 Oct. 11(5):531-7. [QxMD MEDLINE Link].

74. Singer W, Opfer-Gehrking TL, Nickander KK, Hines SM, Low PA. Acetylcholinesterase inhibition in patients with orthostatic intolerance. J Clin Neurophysiol. 2006 Oct. 23(5):476-81. [QxMD MEDLINE Link].

75. Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation. 2005 Jun 7. 111(22):2997-3006. [QxMD MEDLINE Link].

76. Gordon VM, Opfer-Gehrking TL, Novak V, Low PA. Hemodynamic and symptomatic effects of acute interventions on tilt in patients with postural tachycardia syndrome. Clin Auton Res. 2000 Feb. 10(1):29-33. [QxMD MEDLINE Link].

77. Winkler AS, Landau S, Watkins PJ. Erythropoietin treatment of postural hypotension in anemic type 1 diabetic patients with autonomic neuropathy: a case study of four patients. Diabetes Care. 2001 Jun. 24(6):1121-3. [QxMD MEDLINE Link].

78. Mathias CJ, Fosbraey P, da Costa DF, Thornley A, Bannister R. The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. Br Med J (Clin Res Ed). 1986 Aug 9. 293(6543):353-4. [QxMD MEDLINE Link].

79. Dalakas MC. The use of intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: evidence-based indications and safety profile. Pharmacol Ther. 2004 Jun. 102(3):177-93. [QxMD MEDLINE Link].

80. Schroeder C, Vernino S, Birkenfeld AL, Tank J, Heusser K, Lipp A, et al. Plasma exchange for primary autoimmune autonomic failure. N Engl J Med. 2005 Oct 13. 353(15):1585-90. [QxMD MEDLINE Link].

81. Modoni A, Mirabella M, Madia F, Sanna T, Lanza G, Tonali PA, et al. Chronic autoimmune autonomic neuropathy responsive to immunosuppressive therapy. Neurology. 2007 Jan 9. 68(2):161-2. [QxMD MEDLINE Link].

82. Shotton HR, Adams A, Lincoln J. Effect of aminoguanidine treatment on diabetes-induced changes in the myenteric plexus of rat ileum. Auton Neurosci. 2006 Sep 18 [Epub ahead of print]. [QxMD MEDLINE Link].

83. Klein CM. Evaluation and management of autonomic nervous system disorders. Semin Neurol. 2008 Apr. 28(2):195-204. [QxMD MEDLINE Link].

84. Grunfeld A, Murray CA, Solish N. Botulinum toxin for hyperhidrosis: a review. Am J Clin Dermatol. 2009. 10(2):87-102. [QxMD MEDLINE Link].

85. Monteiro E, Perdigoto R, Furtado AL. Liver transplantation for familial amyloid polyneuropathy. Hepatogastroenterology. 1998 Sep-Oct. 45(23):1375-80. [QxMD MEDLINE Link].

86. Tashima K, Ando Y, Terazaki H, et al. Outcome of liver transplantation for transthyretin amyloidosis: follow-up of Japanese familial amyloidotic polyneuropathy patients. J Neurol Sci. 1999 Dec 1. 171(1):19-23. [QxMD MEDLINE Link].

87. Adams D, Gonzalez-Duarte A, O'Riordan WD, Yang CC, Ueda M, Kristen AV, et al. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018 Jul 5. 379 (1):11-21. [QxMD MEDLINE Link]. [Full Text].

88. Adams D, Tournev IL, Taylor MS, Coelho T, Pante-bordeneuve V, Berk JL, et al. HELIOS-A: 9-month results from the phase 3 study of vutrisiran in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy (1234); Presented at the April 19, 2021 at the American Academy of Neurology 2021 Annual Meeting. Neurology. 2021 Apr 13. 96(15 suppl):[Full Text].

89. Amvuttra (vutrisiran) [package insert]. Cambridge, MA: Alnylam Pharmaceuticals. 2022 Jun. Available at [Full Text].

90. Benson MD, Waddington-Cruz M, Berk JL, Polydefkis M, Dyck PJ, Wang AK, et al. Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018 Jul 5. 379 (1):22-31. [QxMD MEDLINE Link]. [Full Text].

91. Antonelli Incalzi R, Fuso L, Pitocco D, et al. Decline of neuroadrenergic bronchial innervation and respiratory function in type 1 diabetes mellitus: a longitudinal study. Diabetes Metab Res Rev. 2006 Oct 2. [QxMD MEDLINE Link].

92. Dawkins JL, Hulme DJ, Brahmbhatt SB, et al. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I. Nat Genet. 2001 Mar. 27(3):309-12. [QxMD MEDLINE Link].

93. El-Atat FA, McFarlane SI, Sowers JR, Bigger JT. Sudden cardiac death in patients with diabetes. Curr Diab Rep. 2004 Jun. 4(3):187-93. [QxMD MEDLINE Link].

94. Holland NR, Crawford TO, Hauer P, et al. Small-fiber sensory neuropathies: clinical course and neuropathology of idiopathic cases. Ann Neurol. 1998 Jul. 44(1):47-59. [QxMD MEDLINE Link].

95. Kamalakannan D, Baskar V, Singh BM. Severe and disabling diabetic autonomic neuropathy: a case report. J Diabetes Complications. 2004 Mar-Apr. 18(2):126-8. [QxMD MEDLINE Link].

96. Kudat H, Akkaya V, Sozen AB, et al. Heart rate variability in diabetes patients. J Int Med Res. 2006 May-Jun. 34(3):291-6. [QxMD MEDLINE Link].

97. Low PA, Caskey PE, Tuck RR, et al. Quantitative sudomotor axon reflex test in normal and neuropathic subjects. Ann Neurol. 1983 Nov. 14(5):573-80. [QxMD MEDLINE Link].

98. Lyu RK, Tang LM, Wu YR, Chen ST. Cardiovascular autonomic function and sympathetic skin response in chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve. 2002 Nov. 26(5):669-72. [QxMD MEDLINE Link].

99. Toth C, Zochodne DW. Other autonomic neuropathies. Semin Neurol. 2003 Dec. 23(4):373-80. [QxMD MEDLINE Link].

100. Zochodne DW, Auer R, Fritzler MJ. Longstanding ataxic demyelinating polyneuronopathy with a novel autoantibody. Neurology. 2003 Jan 14. 60(1):127-9. [QxMD MEDLINE Link].

Steven D Arbogast, DO Fellow, Neuromuscular Medicine, University Hospitals Case Medical Center, Cleveland

Steven D Arbogast, DO is a member of the following medical societies: American Academy of Neurology, American Osteopathic Association

Disclosure: Nothing to disclose.

J Douglas Miles, MD, PhD Assistant Professor of Neuroscience, Marshall University School of Medicine, and Clinical Instructor of Neurology, Case Western Reserve University School of Medicine

J Douglas Miles, MD, PhD is a member of the following medical societies: American Academy of Neurology, American Medical Association, Society for Neuroscience

Disclosure: Nothing to disclose.

Bashar Katirji, MD, FACP Director, Neuromuscular Center and EMG Laboratory, The Neurological Institute, University Hospitals Cleveland Medical Center; Professor of Neurology, Case Western Reserve University School of Medicine

Bashar Katirji, MD, FACP is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American College of Physicians, American Neurological Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Glenn Lopate, MD Associate Professor, Department of Neurology, Division of Neuromuscular Diseases, Washington University in St Louis School of Medicine; Consulting Staff, Department of Neurology, Barnes-Jewish Hospital

Glenn Lopate, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, Phi Beta Kappa

Disclosure: Nothing to disclose.

Nicholas Lorenzo, MD, CPE, MHCM, FAAPL Co-Founder and Former Chief Publishing Officer, eMedicine and eMedicine Health, Founding Editor-in-Chief, eMedicine Neurology; Founder and Former Chairman and CEO, Pearlsreview; Founder and CEO/CMO, PHLT Consultants; Former Chief Medical Officer, MeMD Inc

Nicholas Lorenzo, MD, CPE, MHCM, FAAPL is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, American Association for Physician Leadership

Disclosure: Nothing to disclose.

Paul E Barkhaus, MD, FAAN, FAANEM Professor of Neurology and Physical Medicine and Rehabilitation, Chief, Neuromuscular and Autonomic Disorders Program, Director, ALS Program, Department of Neurology, Medical College of Wisconsin

Paul E Barkhaus, MD, FAAN, FAANEM is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Clinical Neurophysiology Society, American Neurological Association

Disclosure: Nothing to disclose.

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