Neurological Manifestations of Arsenic Intoxication Medication

Updated: Jul 24, 2018
  • Author: Frances M Dyro, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Medication

Medication Summary

The treatment of acute toxicity from arsenic consists primarily of maintaining hydration and electrolyte balance. The use of chelating agents hastens the removal of arsenic from the system. Management of arsine toxicity generally addresses the acute hepatorenal complications. The use of chelating agents in these cases is debatable.

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Chelation agents

Class Summary

These are substances that bind heavy metals in the plasma and render them nontoxic; they also aid in their excretion.

Dimercaprol (BAL in Oil)

British antilewisite is agent of choice in United States. Used as chelator for other heavy metals and stocked as essential item in emergency departments and poison control centers.

Succimer (Chemet)

Licensed by FDA as chelating agent for lead poisoning in children; used successfully to treat arsenic intoxication as well; available as 100-mg capsule.

Penicillamine (Cuprimine, Depen)

Metal chelator used to treat arsenic poisoning; forms soluble complexes with metals excreted in urine.

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