Organic Solvent Neurotoxicity Differential Diagnoses

Updated: Dec 11, 2018
  • Author: Jonathan S Rutchik, MD, MPH, FACOEM; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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DDx

Diagnostic Considerations

Additional conditions to consider include the following:

  • Acute CNS symptoms (rapid onset)
  • Cerebral anoxia
  • Cerebral ischemia
  • Drug overdose
  • Drug toxicity
  • Hyperglycemia or hypoglycemia
  • Metabolic derangements
  • Postictal
  • Thyroid storm
  • Wernicke encephalopathy
  • Meningitis
  • Encephalitis
  • Central pontine myelinolysis Chronic CNS symptoms (slow onset)
  • Pseudodementia (depression)
  • Dementia of Alzheimer type
  • Dementia of multiinfarct type
  • Dementia of normal pressure hydrocephalus (NPH) variant
  • Dementia pugilistica
  • Drug toxicity
  • Nutritional excess of deficit
  • Multiple sclerosis
  • Epilepsy
  • Brain tumor or metastasis
  • Carcinomatous meningitis
  • Encephalitis or meningitis
  • Chronic drug abuse
  • Multiple head trauma history
  • Hepatocerebral syndrome
  • Krabbe leukodystrophy
  • Adult adrenoleukodystrophy Chronic PNS symptoms
  • Diabetes
  • Thyroid disease
  • Uremia
  • Liver disease
  • HIV infection
  • Medication toxicity
  • Lymphoma or other neoplasm
  • Nutritional deficit or excess
  • Syphilis
  • Familial neuropathy
  • Myasthenia gravis
  • Amyotrophic lateral sclerosis
  • Mononeuritis multiplex Other diagnoses to consider
  • Occupational exposures from previous employment
  • Environmental exposures from residence (indoor) and neighborhood (ambient) air and household water
  • Other environmental exposures from commercial products routinely used
  • Exposures from food and food preservatives
  • Paraproteinemic neuropathy

Differential Diagnoses