Organic Solvents Differential Diagnoses

Updated: May 02, 2014
  • Author: Jonathan S Rutchik, MD, MPH, FACOEM; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Diagnostic Considerations

Acute CNS symptoms (rapid onset)

Cerebral anoxia

Cerebral ischemia

Drug overdose

Drug toxicity

Hyperglycemia or hypoglycemia

Metabolic derangements


Thyroid storm

Wernicke encephalopathy



Central pontine myelinolysis Chronic CNS symptoms (slow onset)

Pseudodementia (depression)

Dementia of Alzheimer type

Dementia of multiinfarct type

Dementia of normal pressure hydrocephalus (NPH) variant

Dementia pugilistica

Drug toxicity

Nutritional excess of deficit

Multiple sclerosis


Brain tumor or metastasis

Carcinomatous meningitis

Encephalitis or meningitis

Chronic drug abuse

Multiple head trauma history

Hepatocerebral syndrome

Krabbe leukodystrophy

Adult adrenoleukodystrophy Chronic PNS symptoms


Thyroid disease


Liver disease

HIV infection

Medication toxicity

Lymphoma or other neoplasm

Nutritional deficit or excess


Familial neuropathy

Myasthenia gravis

Amyotrophic lateral sclerosis

Mononeuritis multiplex Other diagnoses to consider

Occupational exposures from previous employment

Environmental exposures from residence (indoor) and neighborhood (ambient) air and household water

Other environmental exposures from commercial products routinely used

Exposures from food and food preservatives

Paraproteinemic neuropathy

Differential Diagnoses